Test Price
2,800 AED✅ Home Collection Available
DNMT3B Gene Immunodeficiency‑Centromeric Instability‑Facial Anomalies Syndrome Type 1 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل تسلسل الجين DNMT3B لمتلازمة نقص المناعة وعدم استقرار المنطقة المركزية وخلل الوجه من النوع الأول في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post‑Test Clinical Guidance in Result Interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: اختبار جيني متطور يعتمد على تقنية التسلسل من الجيل التالي (NGS) للكشف عن الطفرات في جين DNMT3B المرتبطة بمتلازمة ICF1، بدقة تشخيصية تبلغ 99.9% وموثوقية معتمدة من هيئة الصحة بدبي (DHA) بموجب المعيار ISO 9001:2015. نقدم خدمة سحب الدم المنزلي المدفوعة مع استشارة ما بعد التحليل عبر الهاتف لضمان رحلة علاجية آمنة ومتكاملة.
Overview
The DNMT3B Gene Genetic Test delivers a definitive molecular diagnosis for patients with suspected ICF1, facilitating precise clinical management and genetic counselling. يقدم هذا الاختبار تشخيصاً جزيئياً دقيقاً لمتلازمة ICF1 عبر تحليل الطفرات في جين DNMT3B.
| Feature | Our Test (DNMT3B NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 100% coverage of all DNMT3B exons with >99.9% base‑level accuracy | WES may miss deep intronic or regulatory variants; average coverage varies |
| Methodology | Targeted NGS (Hybridization Capture + Illumina Sequencing, validated LC‑MS/MS orthogonal confirmation) | Whole Exome capture with lower read depth per gene; bioinformatic filtering required |
| Speed | Turnaround time 3–4 Weeks | Often 6–8 Weeks with longer interpretation queue |
Physician Insight & Safety Protocol
“As a DHA‑licensed Clinical Geneticist, I encourage you to view this test as part of a broader diagnostic workup. The NGS result – no matter how precise – must be correlated with the patient’s immunological profile and facial dysmorphology by a specialist. For paediatric cases, always obtain informed parental consent and never alter immunosuppressive therapy based solely on the genetic report without specialist consultation.” — Dr. PRABHAKAR REDDY, DHA: 61713011
⚠️ Clinical Notice: Do not discontinue prescribed medication without consulting your doctor.
Patient Safety – Exclusion Criteria & Red Flags
- Exclusion: Recent allogeneic blood transfusion (< 4 weeks) – may contaminate germline DNA with donor cells; postpone collection.
- Exclusion: Known haematologic malignancy with circulating blast cells may cause somatic interference – pre‑test consultation with the laboratory is required.
- Red Flag: If the patient is a minor, valid parental/guardian consent is mandatory under UAE CDS Law 2026 (Child Protection).
- ER Warning: This test is not for acute diagnosis. If the patient presents with severe infection, very low immunoglobulins, or respiratory distress, seek immediate emergency care and defer genetic testing until stabilization.
Frequently Asked Questions & Clinical Guidance
1. What does the DNMT3B NGS test detect and how accurate is it?
Snippet: The test sequences the entire DNMT3B gene using next‑generation sequencing to detect point mutations, small indels, and copy‑number variants with 99.9% diagnostic sensitivity.
It covers all coding exons and splice‑site regions, providing a definitive molecular diagnosis for ICF syndrome type 1 when clinical symptoms align. Our ISO‑accredited laboratory uses orthogonal LC‑MS/MS validation to ensure no false‑positive calls, meeting DHA and international standards.
يكشف الاختبار عن طفرات جين DNMT3B عبر التسلسل الكامل لمناطق ترميز البروتين بدقة 99.9%، ويُعتبر المعيار الذهبي لتشخيص متلازمة ICF1 لدى المرضى المؤهلين سريرياً.
2. How is the sample collected and when will I receive results?
Snippet: A trained phlebotomist collects 2–5 mL of whole blood in an EDTA tube during a home visit (8 AM‑11 PM) or at our DHA‑licensed facility.
We accept dried blood spots (FTA card) or previously extracted DNA if properly preserved. Turnaround time is 3 to 4 Weeks from receipt of a properly consented sample. Expedited reporting can be arranged on a compassionate basis for critically ill children—contact our WhatsApp support.
يتم سحب عينة دم وريدي (2-5 مل) بواسطة ممرض متخصص في المنزل أو في المختبر، مع إمكانية استخدام بطاقة FTA أو حمض نووي مستخلص. تصدر النتائج خلال 3-4 أسابيع.
3. Is genetic counselling included and what happens after the test?
Snippet: A mandatory pre‑test genetic counselling session is included to draw a detailed pedigree and explain the test’s implications.
After results are released, a telephonic post‑ clinical guidance session with a DHA‑licensed geneticist is provided to help interpret findings and plan follow‑up, including family screening and reproductive options. All genetic data is stored in compliance with UAE PDPL and DHAC privacy regulations.
تشمل الخدمة جلسة استشارة وراثية إجبارية قبل الفحص لرسم شجرة العائلة، وجلسة هاتفية بعد النتائج مع أخصائي وراثة معتمد من هيئة الصحة بدبي لشرح النتائج وخطط المتابعة.
Facility License: 9834453 | ISO 9001:2015 Cert: INT/EGQ/2509DA/3139 | Complying with UAE Federal Decree-Law No. 41 of 2024 (Art. 87), CDS Law 2026 (Minors), and UAE PDPL.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians