Test Price
2,800 AED✅ Home Collection Available
DIAPH3 Gene Auditory Neuropathy (Autosomal Dominant) Genetic Test in UAE – 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM.
- Clinical Guidance: Complimentary post-test telephonic genetic counselling with a DHA-licensed specialist.
- Insurance: Direct billing verification & pre-approval via WhatsApp +971 54 548 8731.
All analyses comply with Federal Decree-Law No. 45 of 2021 (PDPL), Federal Law No. 2 of 2019 (ICT in Health Fields), and Federal Decree-Law No. 4 of 2016 (Medical Liability).
Test Overview & Methodology
The DIAPH3 gene sequencing test delivers precise detection of autosomal dominant mutations causing auditory neuropathy spectrum disorder (ANSD), empowering early clinical intervention and family‑centred genetic counselling. This comprehensive next-generation sequencing (NGS) analysis covers all coding exons and intronic boundaries, ensuring >99.9% sensitivity for single nucleotide variants and small indels.
| Feature | Our NGS Test (DIAPH3) | Conventional Sanger Sequencing |
|---|---|---|
| Technology | Next‑Generation Sequencing (Illumina®) | Sanger (single‑amplicon) |
| Analytical Sensitivity | >99.9% for SNVs & small indels across entire coding region | >99% but only for targeted exons |
| Turnaround Time | 3 to 4 Weeks | 6–10 Weeks |
| Clinical Utility | Full diagnostic & carrier screening, haplotype insights | Limited to known familial mutation |
| Regulatory Endorsement | DHA/MOHAP‑recognised, ISO 9001:2015 | May lack UAE accreditation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes:
"This gene test is a cornerstone for families with dominant auditory neuropathy, yet its result must be interpreted alongside audiometric thresholds and neurological assessment. I strongly advise that you never self‑diagnose or modify hearing aid or medication regimens without professional consultation. The report empowers personalised management, but only within a full clinical context."
Advisory: Medication Precautions
Do not discontinue prescribed medication without consulting your doctor.
If you are currently taking ototoxic medications or hearing supplements, do not stop or alter your dosage until reviewed by your treating physician. The genetic test result does not replace medical advice regarding medication adjustments.
Exclusion Criteria & Red Flags
Safety Exclusion Criteria & Emergency Red Flags
- Lack of clinical suspicion of syndromic/non‑syndromic auditory neuropathy or absence of a documented family history of early‑onset hearing loss.
- Patients or guardians unable to give informed consent (mandatory pre‑test genetic counselling).
- Acute onset of sudden hearing loss, severe tinnitus, vertigo, or focal neurological deficits within the last 72 hours – seek emergency ENT evaluation immediately.
- Known contraindications to venipuncture or dried blood spot collection in neonates.
Patient FAQ & Clinical Guidance
1. What is the DIAPH3 gene test and why is it recommended?
This DIAPH3 gene sequencing test identifies mutations causing autosomal dominant auditory neuropathy, enabling precise early diagnosis and family planning. The analysis covers all coding exons of DIAPH3 using high‑coverage NGS, confirming the genetic aetiology behind lifelong sensorineural hearing loss that typically presents at birth or early childhood. Results guide audiological intervention, cochlear implant candidacy, and recurrence risk counselling for relatives.
2. How should I prepare for the DIAPH3 NGS test?
A mandatory pre‑test genetic counselling session collects your family pedigree and ensures you understand the implications of autosomal dominant inheritance. No fasting is required, but you must provide a detailed clinical history of hearing loss, previous audiology reports, and a list of current medications. For infants, a cord blood or heel‑prick FTA card is acceptable; adults can opt for blood draw or buccal swab.
3. What does a positive DIAPH3 result mean for my family?
A positive result confirms the genetic cause of auditory neuropathy and carries a 50% recurrence risk in each pregnancy for an affected parent. Cascade testing can then be offered to at‑risk relatives. Genetic counsellors will interpret the variant’s pathogenicity based on ACMG guidelines and discuss reproductive options such as preimplantation genetic diagnosis (PGD) if desired.
UAE Regulatory & Data Privacy Adherence
Trusted Compliance Framework
- All patient data processed under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical testing procedures and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
- Laboratory accredited under ISO 9001:2015 (Certificate INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | DIAPH3 Gene Sequencing for Auditory Neuropathy (Autosomal Dominant) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (5 mL) or buccal swab; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM to 11 PM |
| Methodology Used | Next‑Generation Sequencing (Illumina®) – Full coding exons + intronic boundaries |
| ICD-10-CM Code | H90.5 (Sensorineural hearing loss, unspecified) |
| LOINC Code | 19239-6 (Auditory neuropathy panel) |
| DHA Facility License & Laboratory Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians