Test Price
2,800 AED✅ Home Collection Available
CRPPA Gene (Walker-Warburg Syndrome) Genetic Test – 2800 AED – DNA Labs UAE
Executive Summary & Core Metrics
Executive Summary & Core Metrics
This ISO 9001:2015 certified test delivers >99.9% diagnostic sensitivity for pathogenic CRPPA variants, processed in a DHA-licensed facility (License 1143). Our end-to-end service includes genetic counselling, VIP mobile phlebotomy and temperature-controlled cold-chain home collection, and telehealth result interpretation by DHA-credentialed experts, fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The CRPPA gene (formerly ISPD) is essential for alpha-dystroglycan glycosylation. Pathogenic variants cause Walker-Warburg syndrome, the most severe form of congenital muscular dystrophy with brain and eye anomalies. This NGS-based test sequences the entire coding region of the CRPPA gene, detecting single nucleotide variants, small indels, and copy number changes with clinical-grade accuracy.
| Parameter | Our Test (UAE) | Alternative Single-Gene Sanger |
|---|---|---|
| Methodology | NGS (full coding + CNV) | Sanger Sequencing |
| Detection Rate | >99.9% (SNVs, indels, CNVs) | ~95% (only targeted regions) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Sample Types | Blood, DNA, FTA Card | Blood, DNA |
| Accreditation | ISO 9001:2015 + DHA | Variable |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics licensed by DHA (9294403), I emphasise that the CRPPA gene test provides a definitive molecular diagnosis for suspected Walker-Warburg syndrome, especially when coupled with prenatal imaging and clinical findings. Results must be interpreted within the context of a full pedigreed genetic counselling session; a negative result does not exclude other genetic causes of a similar phenotype.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Medication Warnings
⚠ Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
This genetic test is for diagnostic purposes only and does not replace neurological or supportive care. Continue all treatments as directed by your neurologist or pediatrician.
Exclusion Criteria & Red Flags
- Acute illness: Blood draw not recommended during febrile episodes; reschedule after recovery.
- Recent blood transfusion: Wait at least 4 weeks to avoid donor DNA interference.
- Pregnancy: Test can be performed, but prenatal counselling is mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flag Symptoms: If the patient experiences seizures, severe respiratory distress, or inconsolable crying in an infant, seek emergency medical care immediately — this test is not an emergency procedure.
- Minor Consent: For children under 18, written informed consent from legal guardian required in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does the CRPPA gene test detect, and why is it ordered for suspected Walker-Warburg syndrome?
This NGS test identifies pathogenic variants in the entire CRPPA gene, confirming the molecular cause of severe congenital muscular dystrophy with brain and eye anomalies when clinical signs such as cobblestone lissencephaly, retinal dysplasia, and hypotonia are present.
2. How should I prepare for the blood collection, and is genetic counselling required?
No fasting is needed; our certified phlebotomist collects 2–4 ml of whole blood at home, and a mandatory pre-test genetic counselling session is included to draw a pedigree and explain implications, as required by Federal Decree-Law No. 45 of 2021 (PDPL).
3. Can this test be used for prenatal diagnosis, and what are the UAE legal requirements?
Yes, it can be applied to prenatal samples (amniocytes or chorionic villi) after invasive procedures; however, Federal Decree-Law No. 4 of 2016 mandates ethical committee approval for prenatal genetic testing of severe disorders, ensuring full compliance.
4. What is the turnaround time, and how will I receive my results?
Turnaround time is 3–4 weeks from sample receipt. Results are delivered via a secure patient portal and discussed in a follow-up telehealth consultation with our genetics specialist.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed under DHA Facility License 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. We adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All patient data is encrypted and handled in compliance with UAE data protection standards.
Clinical & Logistical Metadata
| Test Name | CRPPA Gene (Walker-Warburg Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region + CNV analysis |
| ICD-10-CM Code | Q87.8 (Other specified congenital malformation syndromes) |
| LOINC Code | 21636-6 (DNA sequencing) |
| DHA Facility License & Laboratory Address | License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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