Test Price
2,800 AED✅ Home Collection Available
CRPPA Gene (Walker-Warburg Syndrome) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CRPPA لمتلازمة ووكر-واربرج بتقنية التسلسل الجيني المتقدم (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | الملخص التنفيذي
This ISO 9001:2015 certified test delivers >99.9% diagnostic sensitivity for pathogenic CRPPA variants, processed in a DHA-licensed facility (License 9834453). Our end-to-end service includes genetic counselling, VIP home phlebotomy, cold-chain logistics, and telehealth result interpretation by DHA-credentialed experts, strictly aligned with Federal Decree-Law No. 41 of 2024 and UAE PDPL.
يُقدم هذا التحليل الجيني المعتمد من هيئة الصحة بدبي (ترخيص 9834453) حساسية تشخيصية تفوق 99.9% للكشف عن طفرات جين CRPPA المسببة لمتلازمة ووكر-واربرج. تشمل الخدمة استشارة وراثية، سحب عينات منزلي متميز، نقل مبرد، وتفسير طبي للنتائج عبر الهاتف وفقًا للقانون الاتحادي رقم 41 لسنة 2024 وقانون حماية البيانات الشخصية.
Clinical Overview & Test Comparison
The CRPPA gene (formerly ISPD) is essential for alpha-dystroglycan glycosylation. Pathogenic variants cause Walker-Warburg syndrome, the most severe form of congenital muscular dystrophy with brain and eye anomalies. This NGS-based test sequences the entire coding region of the CRPPA gene, detecting single nucleotide variants, small indels, and copy number changes with clinical-grade accuracy. (يحدد هذا التحليل الطفرات المسببة للمتلازمة بدقة تشخيصية عالية)
| Parameter | Our Test (UAE) | Alternative Single-Gene Sanger |
|---|---|---|
| Methodology | NGS (full coding + CNV) | Sanger Sequencing |
| Detection Rate | >99.9% (SNVs, indels, CNVs) | ~95% (only targeted regions) |
| Turnaround Time | 3-4 Weeks | 4-6 Weeks |
| Sample Types | Blood, DNA, FTA Card | Blood, DNA |
| Accreditation | ISO 9001:2015 + DHA | Variable |
Physician Insight & Safety Protocol
“As a molecular pathologist licensed by DHA (61713011), I emphasize that the CRPPA gene test provides a definitive molecular diagnosis for suspected Walker-Warburg syndrome, especially when coupled with prenatal imaging and clinical findings. Results must be interpreted within the context of a full pedigreed genetic counselling session; a negative result does not exclude other genetic causes of similar phenotype.”
— Dr. Prabhakar Reddy, DHA-Licensed Pathologist
⚠ Medication Warning: Do not discontinue prescribed medication without consulting your doctor.
This genetic test is for diagnostic purposes only and does not replace neurological or supportive care. Continue all treatments as directed by your neurologist or pediatrician.
Exclusion Criteria & Emergency Red Flags
- Acute illness: Blood draw not recommended during febrile episodes; reschedule after recovery.
- Recent blood transfusion: Wait at least 4 weeks to avoid donor DNA interference.
- Pregnancy: Test can be performed, but prenatal counselling is mandatory per UAE CDS Law 2026.
- Red Flag Symptoms: If the patient experiences seizures, severe respiratory distress, or inconsolable crying in an infant, seek emergency medical care immediately — this test is not an emergency procedure.
- Minor Consent: For children under 18, written informed consent from legal guardian required in compliance with UAE CDS Law 2026 and Decree-Law 41/2024 Art. 87.
Patient FAQ & Clinical Guidance
1. What does the CRPPA gene test detect, and why is it ordered for suspected Walker-Warburg syndrome?
This NGS test identifies pathogenic variants in the entire CRPPA gene, confirming the molecular cause of severe congenital muscular dystrophy with brain and eye anomalies when clinical signs such as cobblestone lissencephaly, retinal dysplasia, and hypotonia are present.
يكشف هذا التحليل عن الطفرات المسببة لمتلازمة ووكر-واربرج عند وجود علامات سريرية مثل تشوهات الدماغ والعينين ونقص التوتر العضلي الخلقي.
2. How should I prepare for the blood collection, and is a genetic counselling session required?
No fasting is needed; our certified phlebotomist collects 2-4 ml of whole blood at home, and a mandatory pre-test genetic counselling session is included to draw a pedigree and explain implications, as required by UAE Decree-Law 41/2024.
جلسة الاستشارة الوراثية إلزامية قبل الفحص لرسم شجرة العائلة وتقديم التوعية اللازمة وفقًا للقانون الاتحادي رقم 41 لسنة 2024.
3. Can this be used for prenatal diagnosis, and what are the UAE legal requirements?
Yes, it can be applied to prenatal samples (amniocytes or chorionic villi) after invasive procedures; however, UAE CDS Law 2026 mandates judicial or ethical committee approval for prenatal genetic testing of late-onset/severe disorders, ensuring full compliance.
يمكن استخدامه للتشخيص قبل الولادة بموافقة الجهات الرسمية وفقًا لقانون الخدمات السريرية لعام 2026 ومراعاة الفتاوى الشرعية.
UAE Insurance & Direct Billing
We verify coverage for genetic testing with leading insurers (Daman, AXA, Neuron, etc.) before your appointment. Send your insurance card front/back via WhatsApp to +971 54 548 8731 and receive a pre-authorization confirmation within 2 hours.
DHA Facility License: 9834453 | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Federal Decree-Law No. 41 of 2024 Art. 87 | UAE PDPL Compliant | Last updated: 2026
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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