Test Price
2,800 AED✅ Home Collection Available
COMT Gene Catechol-O-Methyltransferase Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Executive Summary & Core Metrics
The COMT gene encoding catechol-O-methyltransferase is critical for the breakdown of dopamine, epinephrine, and norepinephrine. This next-generation sequencing (NGS) test comprehensively analyzes the entire COMT gene for pathogenic variants linked to catechol-O-methyltransferase deficiency, a metabolic disorder that can affect neurotransmitter balance, cognitive function, and estrogen metabolism. Analysis delivers a complete genetic profile with bioinformatic interpretation per ACMG guidelines.
Test Overview & Methodology
Our NGS test reads every base pair of the COMT gene multiple times, achieving >99.9% diagnostic sensitivity and full coverage of rare mutations. Results are interpreted by board-certified molecular geneticists using ACMG classifications, providing clinical-grade reliability that surpasses single-SNP kits used in direct-to-consumer testing.
| Feature | Our NGS Genetic DNA Test | Closest Alternative (PCR-based targeted) |
|---|---|---|
| Precision | Full gene sequencing – detects all single nucleotide variants, indels, and copy number changes | Limited to known common polymorphism (e.g., Val158Met) only |
| Methodology | NGS with bioinformatic analysis and clinical interpretation per ACMG guidelines | Real-time PCR / SNP genotyping |
| Speed (TAT) | 3–4 Weeks | 5–7 Days (but incomplete data) |
Physician Insight & Safety Protocols
“Understanding your catecholamine pathway through this genetic lens can feel overwhelming, but knowledge empowers you and your doctor to tailor lifestyle and medical choices. This test is a powerful tool—use it alongside professional clinical correlation. Remember, no single gene defines your health journey; we are here to support you.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Clinical Advisory: Do not discontinue prescribed medication without consulting your doctor.
Genetic results for COMT variants should never replace current pharmacotherapy. Always discuss findings with your prescribing physician before making medication or supplement changes.
Exclusion Criteria & Safety Flags
- Exclusion: Recent allogeneic hematopoietic stem cell transplant (within 6 months).
- Exclusion: Active severe infection or febrile illness that might compromise sample integrity.
- Emergency Warning: Seek immediate medical care if you experience suicidal ideation, acute psychosis, or sudden neurological deterioration—this test is not for emergency diagnosis.
- Vulnerable Populations: Genetic testing in minors requires informed consent by legal guardian per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the COMT gene and why test for its deficiency?
The COMT gene encodes an enzyme that breaks down dopamine and related neurotransmitters; its deficiency can cause cognitive, behavioral, and metabolic issues. Testing identifies pathogenic variants that may explain symptoms like anxiety, chronic fatigue, or mood disorders, guiding personalized interventions including medication selection and nutrient supplementation.
2. How does the NGS test guarantee high accuracy for COMT variants?
Our NGS technology reads every base pair of the COMT gene multiple times, achieving >99.9% diagnostic sensitivity and full coverage of rare mutations. The results are interpreted by board-certified molecular geneticists using ACMG classifications, ensuring clinical-grade reliability that surpasses single‑SNP kits used in direct‑to‑consumer testing.
3. Is a doctor’s referral required and how does home sample collection work in Dubai?
A doctor’s referral is not mandatory for this genetic test; you can self-order and our team assists with all legal consents. Collection is available across Dubai and the UAE from 8 AM to 11 PM via trained phlebotomists using a cold‑chain transport kit for blood or extracted DNA—all compliant with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
4. What results can I expect and how are they communicated?
Results include a detailed clinical report listing detected variants, their ACMG classification (pathogenic, likely pathogenic, or benign), and explanatory text for your physician. Reports are delivered securely via encrypted email or portal within 3–4 weeks from sample receipt.
5. Can the results affect my insurance or employment?
Under UAE Federal Decree-Law No. 45 of 2021 (PDPL), your genetic data is strictly confidential and cannot be used for discriminatory purposes. We never share your results with employers or insurers without your explicit written consent.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Data Protection: Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health ICT: Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: Federal Decree-Law No. 4 of 2016 on Medical Liability (informed consent for genetic testing).
- Certification: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | COMT Gene Catechol-O-Methyltransferase Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with bioinformatic analysis per ACMG guidelines |
| ICD-10-CM Code | E70.8, Z15.8, F79 |
| LOINC Code | 90535-9 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians