Test Price
2,800 AED✅ Home Collection Available
CD59 Gene Sequencing (NGS) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: This advanced diagnostic test employs next-generation sequencing (NGS) to analyze the CD59 gene with 99.9% analytical sensitivity, enabling definitive diagnosis of CD59-mediated hemolytic anemia with or without immune-mediated polyneuropathy. The test is processed in ISO 9001:2015 certified laboratories (Cert: INT/EGQ/2509DA/3139) with VIP mobile phlebotomy home collection across the UAE and telephonic post-result genetic counseling by a DHA-licensed genetics specialist.
Test Overview & Methodology
CD59 gene sequencing identifies pathogenic variants causing a rare form of chronic hemolytic anemia with or without immune-mediated polyneuropathy—the only definitive way to confirm congenital CD59 deficiency. This NGS assay interrogates the entire coding region and splice sites, delivering actionable results for targeted therapies such as anti-C5 monoclonal antibodies and informed family planning. The bioinformatics pipeline is validated for single nucleotide variants and small insertions or deletions with greater than 99.9% analytical sensitivity.
| Feature | Our NGS Test | Closest Alternative |
|---|---|---|
| Precision | Greater than 99.9% analytical sensitivity for single nucleotide variants and small indels in CD59 | Sanger sequencing may miss low-level mosaicism; limited to known exons only |
| Method | Illumina-based NGS with orthogonal confirmation of all clinically significant variants | PCR-based fragment analysis or Sanger sequencing with slower turnaround |
| Speed | 3–4 weeks definitive report, including variant classification per ACMG standards | 6–8 weeks with potential reflex testing rounds |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I recognize the diagnostic challenges posed by rare genetic anemias. This NGS-based CD59 gene sequencing provides definitive molecular confirmation, enabling precise therapeutic targeting with complement inhibitors and informed family counseling. Genetic test results must always be interpreted in conjunction with clinical phenotype and family history to guide management decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue prescribed medication without consulting your doctor. Drugs such as erythropoietin, immunosuppressants, or complement inhibitors may influence test interpretation or require gradual tapering. Self-adjustment of therapy can trigger acute hemolytic crisis or neuropathic worsening. Always discuss any medication changes with your treating physician before the test.
Exclusion Criteria & Emergency Red Flags
- Recent blood transfusion (within 4 weeks) may mask hemolytic markers; defer test if possible.
- Uncontrolled coagulopathy or severe thrombocytopenia — sample collection on FTA card preferred.
- Active central nervous system infection (meningitis/encephalitis) — delay elective genetic workup.
- Emergency red flags: Sudden severe hemolysis (dark urine, jaundice, dyspnea), ascending paralysis, or respiratory failure — go to emergency immediately, do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the accuracy of this CD59 gene test and which variants can it detect?
Our NGS assay achieves greater than 99.9% analytical sensitivity for single nucleotide variants and small insertions or deletions in the CD59 gene. The clinically validated bioinformatics pipeline also identifies splice-site alterations and exonic deletions. All clinically significant findings are confirmed by orthogonal sequencing methods before reporting.
2. Which sample types are accepted and can I arrange home collection in Dubai or Abu Dhabi?
We accept whole blood in lavender-top EDTA tubes, extracted DNA, or a one-drop blood FTA card. Our VIP mobile phlebotomy team covers all UAE emirates including Dubai, Abu Dhabi, and Sharjah. Appointments are available daily from 8 AM to 11 PM with temperature-controlled cold-chain transport to the laboratory.
3. Will my insurance cover this test and when will I receive results?
Results are delivered within 3–4 weeks from sample receipt. Our dedicated insurance team verifies pre-approval via WhatsApp before scheduling collection, minimizing unexpected out-of-pocket costs. Direct billing is available for most major UAE health insurance providers.
UAE Regulatory & Data Privacy Adherence
Your data and safety are protected under UAE Federal Law. All genetic testing procedures adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols strictly follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information is encrypted, stored securely, and never shared with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | CD59 Gene Sequencing (NGS) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina Platform |
| ICD-10-CM Code | D59.8 |
| LOINC Code | 90420-0 |
| DHA Facility License & Address | DHA License No: 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians