Test Price
2,800 AED✅ Home Collection Available
CACNA1B (DYT23) Gene NGS Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
Precision Genetic Diagnosis for DYT23 Dystonia
This next-generation sequencing (NGS) test analyzes the CACNA1B gene to detect pathogenic variants causing DYT23, an early-onset isolated dystonia. Results provide a definitive molecular diagnosis to guide targeted therapy, genetic counselling, and family planning under DHA-licensed protocols.
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test counselling by DHA-licensed genetics professionals to interpret results.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The CACNA1B (DYT23) NGS test sequences the entire coding region of the CACNA1B gene using Illumina NovaSeq™ next-generation sequencing with bioinformatic validation against curated medical datasets. This approach detects single nucleotide variants, indels, and copy-number changes across the full gene with 99.9% sensitivity, delivering a definitive molecular diagnosis for early-onset isolated dystonia.
| Feature | Our Test (CACNA1B NGS – DHA Precision) | Closest Alternative (Sanger Sequencing / Panel) |
|---|---|---|
| Precision | 99.9% sensitivity for single nucleotide variants, indels, and CNVs across the full gene | ~95% for selected exons; may miss deep intronic or copy-number changes |
| Methodology | Illumina NovaSeq™ NGS with bioinformatic validation against curated medical datasets | Capillary Sanger sequencing or limited dystonia panel |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks (often extended for reflex testing) |
| Price | AED 2,800 (all-inclusive) | AED 2,500 – 3,500 (limited coverage) |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I see how a precise molecular diagnosis for DYT23 can transform patient care by confirming the underlying aetiology and enabling tailored surveillance and family counselling. However, genetic results must always be interpreted alongside a thorough clinical evaluation and should never be used as the sole basis for treatment decisions.”
Advisory Notice
Do not discontinue or alter any prescribed medication without consulting your treating physician. Genetic test results are intended to inform clinical decision-making and should be used in conjunction with a complete medical assessment.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals unable to provide informed consent (minors require guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability), known bleeding diathesis if blood draw required, active infection at venipuncture site.
- Emergency Red Flags (seek immediate medical attention): Sudden severe dystonic storm, difficulty breathing or swallowing, loss of consciousness, status dystonicus.
Patient FAQ & Clinical Guidance
1. What is the CACNA1B (DYT23) test and why is it important?
Direct answer: This NGS test identifies pathogenic mutations in the CACNA1B gene causing DYT23 dystonia, enabling early diagnosis, targeted treatment, and informed family planning.
The test is recommended when a patient shows signs of early-onset isolated dystonia, especially with a family history. It is performed on a blood sample or DNA extraction and takes 3–4 weeks for results. Positive findings can guide neurologists in selecting appropriate therapy and counselling relatives about genetic risk.
2. How is the CACNA1B gene test performed and what is the turnaround time?
Direct answer: A simple blood sample is collected via our VIP mobile phlebotomy service (8 AM to 11 PM) or at an approved collection centre. The sample is processed using Illumina NovaSeq™ NGS technology, with final results delivered within 3 to 4 weeks.
Our logistics team coordinates temperature-controlled cold-chain transport to the ISO 9001:2015 accredited laboratory. After results are ready, a DHA-licensed genetics professional provides telephonic interpretation and clinical guidance.
3. Is this test covered by insurance in the UAE?
Direct answer: We verify direct billing eligibility with major UAE insurers before testing. Simply send your insurance card via WhatsApp to +971 54 548 8731 for confirmation.
Coverage varies by plan, but our billing team assists in obtaining approval. The test is priced at AED 2,800 and is recognized under DHA-licensed genetic testing guidelines for neurological disorders when medically indicated.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
- All personal health data is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Clinical testing and patient consent follow the requirements of Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical liability and patient safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DNA Labs UAE is DHA-licensed (Facility License: 1143) and ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CACNA1B (DYT23) Gene NGS Test |
| Price (AED) | AED 2,800 (all-inclusive) |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection) |
| Methodology Used | Illumina NovaSeq™ Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G24.1 |
| LOINC Code | 94705-0 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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