Test Price
2,800 AED✅ Home Collection Available
ALX3 Gene Frontonasal Dysplasia Type 1 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ALX3 لخلل التنسج الجبهي الأنفي النوع الأول بتقنية التسلسل الجيني الفائق (NGS) في الإمارات | 2800 درهم | دليل هيئة الصحة بدبي 2026
✅ Executive Summary & UAE Healthcare Assurance
- 🔬Diagnostic Sensitivity 99.9% via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139), ensuring unambiguous ALX3 mutation detection.
- 🚑Hospital‑Grade Home Collection (8 AM – 11 PM, 7 days) with ISO‑certified cold‑chain logistics and VIP mobile phlebotomy.
- 📞Post‑Test Clinical Guidance – a dedicated telephonic session with a DHA‑licensed genetic counsellor to interpret results and plan next steps.
- 📋Direct Insurance Billing Verification via WhatsApp at +971 54 548 8731.
ملخص تنفيذي: يضمن مختبرنا المعتمد وفقاً للمواصفة القياسية ISO 9001:2015 نتائج جينية فائقة الدقة بنسبة 99.9% لتشخيص خلل التنسج الجبهي الأنفي من النوع الأول الناتج عن طفرات جين ALX3، مع خدمة سحب منزلي متميزة وإرشاد سريري متكامل بعد الفحص.
Clinical Overview: Why This Test Matters
ALX3 gene sequencing identifies pathogenic variants in the ALX3 transcription factor critical for craniofacial development, confirming Type 1 frontonasal dysplasia – a rare congenital malformation syndrome characterised by hypertelorism, bifid nose, and midline clefting. (يكشف تسلسل جين ALX3 عن الطفرات المسببة لخلل التنسج الجبهي الأنفي النمط الأول، وهو اضطراب خلقي نادر في تطور الوجه والجمجمة.)
Our NGS test provides full gene coverage with superior analytical sensitivity, enabling definitive diagnosis, accurate recurrence risk counselling, and personalised management strategies.
| Feature | Our Test (NGS) – ALX3 Full Gene | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (Illumina® platform), ISO 15189 protocols | Sanger sequencing of selected exons only |
| Mutation Detection | Complete coding region ± splice sites; copy number variations (CNVs) also detected | Point mutations and small indels; CNVs often missed |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks typically |
| Clinical Confidence | >99.9% analytical sensitivity for SNVs and indels | ~95% for the regions sequenced |
| Report | Comprehensive with ACMG variant interpretation & clinical correlation notes | Variant call only; limited interpretation |
Sample types accepted: Whole blood, extracted DNA, or one drop of blood on an FTA card.
Physician Insight & Safety Protocol – Dr. Prabhakar Reddy (DHA: 61713011)
“A clinical suspicion of frontonasal dysplasia demands genetic confirmation to guide both surgical and neurodevelopmental care. While a positive ALX3 result clarifies the diagnosis, normal sequencing does not exclude other craniofacial syndromes; therefore, every test must be interpreted in the context of a complete clinical evaluation and, when indicated, additional genetic studies. As your physician, I am here to ensure that no family navigates this journey alone.”
— Dr. Prabhakar Reddy, Specialist Pediatrician & Genetic Counsellor
⚠️ Medication Warning
Do not discontinue any prescribed medication or alter your child’s treatment regimen without direct consultation with the managing physician. This genetic test is for diagnostic clarification and does not replace acute medical management.
🚨 Exclusion Criteria & Emergency Red Flags
- Exclusion: Active severe infection with haemodynamic instability – postpone sample collection until clinically stable.
- Exclusion: Inability to obtain a minimum of 0.5 mL blood or equivalent DNA concentration.
- ER Alert: If the patient develops acute respiratory distress, cyanosis, uncontrollable seizures, or signs of raised intracranial pressure, seek immediate emergency care – do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the ALX3 gene test, and why is it recommended for my child?
Snippet: The ALX3 gene detects disease‑causing mutations responsible for frontonasal dysplasia type 1, a rare congenital condition affecting facial and skull development, enabling definitive diagnosis and tailored medical management.
سنيب: يكشف تحليل جين ALX3 عن الطفرات المسببة لخلل التنسج الجبهي الأنفي النمط الأول، مما يتيح تشخيصاً دقيقاً وخطة رعاية طبية مخصصة للطفل.
2. How is the sample collected, and is it painful for my baby?
Snippet: A small venous blood sample, a drop of blood on a special FTA card, or a previously extracted DNA sample is collected by a certified paediatric phlebotomist using techniques that minimise discomfort, often with topical anaesthesia if needed.
سنيب: تُسحب عينة دم وريدية صغيرة أو قطرة دم على بطاقة FTA بواسطة أخصائي سحب دم أطفال معتمد باستخدام تقنيات تقلل الألم، مع إمكانية استخدام مخدر موضعي.
3. How long until I receive the results and what does the 2800 AED fee include?
Snippet: Results are typically delivered within 3 to 4 weeks; the 2800 AED fee covers hospital‑grade home collection, cold‑chain transport, full NGS sequencing, a clinical interpretive report, and a tele‑counselling session.
سنيب: تصدر النتائج عادةً خلال 3 إلى 4 أسابيع، ويشمل مبلغ 2800 درهماً خدمة السحب المنزلي المعتمدة، والنقل المبرد، وتحليل التسلسل الكامل، والتقرير التفسيري، وجلسة استشارة هاتفية.
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