Test Price
2,800 AED✅ Home Collection Available
ALX3 Gene Frontonasal Dysplasia Type 1 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- 🔬Diagnostic Sensitivity 99.9% via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139), ensuring unambiguous ALX3 mutation detection.
- 🚑VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM, 7 days) with ISO‑certified logistics.
- 📞Post-Test Clinical Guidance – a dedicated telephonic session with a DHA‑licensed consultant medical geneticist to interpret results and plan next steps.
- 📋Direct Insurance Billing Verification via WhatsApp at +971 54 548 8731.
- 💰Price: 2,800 AED – includes collection, sequencing, interpretive report, and post-test counselling.
- ⏱️Turnaround Time: 3 to 4 weeks from sample receipt.
Test Overview & Methodology
ALX3 gene sequencing identifies pathogenic variants in the ALX3 transcription factor critical for craniofacial development, confirming Type 1 frontonasal dysplasia – a rare congenital malformation syndrome characterised by hypertelorism, bifid nose, and midline clefting. Our NGS test provides full gene coverage with superior analytical sensitivity, enabling definitive diagnosis, accurate recurrence risk counselling, and personalised management strategies.
| Feature | Our Test (NGS) – ALX3 Full Gene | Closest Alternative (Targeted Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (Illumina® platform), ISO 15189 protocols | Sanger sequencing of selected exons only |
| Mutation Detection | Complete coding region ± splice sites; copy number variations (CNVs) also detected | Point mutations and small indels; CNVs often missed |
| Turnaround Time | 3 – 4 weeks | 6 – 8 weeks typically |
| Clinical Confidence | >99.9% analytical sensitivity for SNVs and indels | ~95% for the regions sequenced |
| Report | Comprehensive with ACMG variant interpretation & clinical correlation notes | Variant call only; limited interpretation |
Sample types accepted: Whole blood, extracted DNA, or one drop of blood on an FTA card.
Physician Insight & Safety Protocols
“When evaluating a child with suspected frontonasal dysplasia, molecular confirmation through ALX3 sequencing provides the cornerstone for accurate diagnosis, family counselling, and coordinated multidisciplinary care. A negative result does not exclude all craniofacial syndromes, so comprehensive clinical correlation remains essential. Our team is committed to guiding each family through the testing process and beyond.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Precautions
⚠️ Important Clinical Reminder
This genetic test is intended for diagnostic clarification and recurrence risk assessment. It does not replace urgent medical or surgical intervention. Always consult your managing physician before making any changes to ongoing treatments or therapies.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active severe infection with haemodynamic instability – postpone sample collection until clinically stable.
- Exclusion: Inability to obtain a minimum of 0.5 mL blood or equivalent DNA concentration.
- Emergency Alert: If the patient develops acute respiratory distress, cyanosis, uncontrollable seizures, or signs of raised intracranial pressure, seek immediate emergency care – do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the ALX3 gene test, and why is it recommended for my child?
The ALX3 gene detects disease‑causing mutations responsible for frontonasal dysplasia type 1, a rare congenital condition affecting facial and skull development, enabling definitive diagnosis and tailored medical management. This testing is advised when clinical features such as hypertelorism, bifid nose, or midline clefting are observed.
2. How is the sample collected, and is it painful for my baby?
A small venous blood sample, a drop of blood on a special FTA card, or a previously extracted DNA sample is collected by a certified paediatric phlebotomist using techniques that minimise discomfort, often with topical anaesthesia if needed. The procedure is quick and designed to be as gentle as possible for infants and children.
3. How long until I receive the results and what does the 2800 AED fee include?
Results are typically delivered within 3 to 4 weeks; the 2,800 AED fee covers hospital‑grade home collection, cold‑chain transport, full NGS sequencing, a clinical interpretive report, and a tele‑counselling session with a consultant medical geneticist.
4. Will insurance cover the cost of this genetic test?
Coverage varies by insurer and policy. We recommend verifying your benefits directly via WhatsApp at +971 54 548 8731 for a personalised pre-authorisation check before proceeding.
5. Can this test be performed during pregnancy?
Prenatal testing for ALX3 variants is available on a case-by-case basis following genetic counselling. Please contact our team to discuss the appropriate sampling pathway and consent process for prenatal diagnosis.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE federal law. DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic information is encrypted, access‑controlled, and used solely for diagnostic and counselling purposes as authorised by the referring physician.
Clinical & Logistical Metadata
| Test Name | ALX3 Gene Frontonasal Dysplasia Type 1 Genetic Test (NGS Full Gene Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card blood spot |
| Methodology Used | Next-Generation Sequencing (Illumina® platform, ISO 15189 protocols) |
| ICD-10-CM Code | Q75.8 (Other specified congenital malformations of skull and face bones) |
| LOINC Code | 81247-9 (Genetic analysis for hereditary disease) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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