Test Price
2,800 AED✅ Home Collection Available
ALOX12B Gene Sequencing for Autosomal Recessive Congenital Ichthyosis Type 2 – Genetic Diagnostic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity achieved through ISO 15189:2012 accredited Next‑Generation Sequencing (NGS) processing on the Illumina® platform.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary post‑test telephonic consultation with our Consultant Medical Geneticist to integrate results into your personal and family health strategy.
- Insurance & Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
- Corporate Oversight: Performed under the supervision of Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA ID: 9294403) at DNA Labs UAE.
Test Overview & Methodology
The ALOX12B Genetic Test employs clinical‑grade next‑generation sequencing to detect pathogenic variants in the ALOX12B gene, which are responsible for autosomal recessive congenital ichthyosis type 2 (ARCI2). This severe scaling skin disorder can now be diagnosed with single‑nucleotide resolution, ensuring accurate classification and informed family planning.
| Feature | Our Test (ALOX12B NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | Single‑nucleotide resolution, whole gene coverage | Limited to predefined exons |
| Methodology | Next‑Generation Sequencing (Illumina® platform) | Sanger sequencing |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA ID: 9294403
“The ALOX12B sequencing test provides definitive molecular confirmation of autosomal recessive congenital ichthyosis type 2, enabling precise genetic counselling and tailored dermatological management. A positive result clarifies the diagnosis but must be contextualised within the full clinical picture. I strongly recommend discussing all findings with your treating physician to develop a comprehensive care plan that addresses both cutaneous symptoms and potential systemic implications.”
Advisory Safety Information
Important Clinical Advisory
Do not discontinue or alter any prescribed medication without first consulting your treating physician. This genetic test provides diagnostic information and does not replace ongoing clinical supervision or emergency medical care.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Inability to provide informed consent personally or via a legal guardian.
- Minors presenting without a parent or legally authorised guardian.
- Active systemic infection requiring immediate medical intervention.
Emergency Red Flags (Post‑Collection)
- Signs of infection at the venepuncture site (increasing redness, swelling, warmth, or purulent discharge).
- Severe or uncontrolled bleeding from the puncture site.
- Fainting episode with prolonged or incomplete recovery.
If any of these occur, seek immediate medical attention or contact our 24/7 helpline at +971 54 548 8731.
Patient FAQ & Clinical Guidance
1. What is the ALOX12B Gene Sequencing Test, and why is it performed?
This test uses clinical‑grade next‑generation sequencing to detect pathogenic mutations in the ALOX12B gene that cause autosomal recessive congenital ichthyosis type 2 (ARCI2). It is performed to confirm the molecular diagnosis in individuals presenting with severe scaling skin, to guide genetic counselling for families, and to inform long‑term dermatological and systemic management strategies.
2. Who should consider this test, and which specialists oversee the process?
The test is recommended for infants and children with clinical features of congenital ichthyosis, individuals with a family history of ARCI2, and couples planning a family who wish to assess carrier status. The testing pathway is overseen by our Consultant Medical Geneticist, with input from dermatologists, paediatricians, and clinical geneticists as needed to ensure comprehensive care.
3. How is the sample collected, and when can I expect the results?
A standard peripheral blood sample is collected by our certified mobile phlebotomy team at your home or at a DNA Labs UAE collection centre. Alternatively, an FTA card spot or an extracted DNA sample may be accepted. The turnaround time is 3–4 weeks from sample receipt. A complimentary post‑test telephonic consultation with our genetic specialist is included to help you understand your results.
UAE Regulatory & Data Privacy Adherence
✔ UAE Healthcare Compliance & Data Protection
This genetic test is performed in full compliance with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, storage, and processing of personal and genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – regulating health information systems and digital health data.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability – ensuring patient safety and clinical accountability.
All genetic sequence data is stored and processed exclusively within UAE‑sovereign health clouds. DNA Labs UAE holds DHA Facility License No. 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | ALOX12B Gene Sequencing for Autosomal Recessive Congenital Ichthyosis Type 2 |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), FTA Card Spot, or Extracted DNA |
| Methodology Used | Next‑Generation Sequencing (Illumina® platform), Whole Gene Coverage |
| ICD-10-CM Code | Q80.2 (Other congenital ichthyosis) |
| LOINC Code | 94471-6 (Inherited disease-associated variants detected in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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