Test Price
2,800 AED✅ Home Collection Available
ALDH3A2 Gene Sequencing for Sjögren-Larsson Syndrome Diagnosis – DHA Licensed Genetic Test in Dubai
Executive Summary & Core Metrics
UAE Trusted Genetic Diagnostic Service – Confirmed Pathogenic Variant Detection
- 99.9% Diagnostic Sensitivity – Next-generation sequencing (NGS) analysis of all coding exons and flanking intronic regions of the ALDH3A2 gene, validated with bioinformatics variant calling pipelines in our ISO 9001:2015 certified laboratory.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM. A certified phlebotomist visits your residence with ISO compliant cold-chain transport to preserve DNA integrity from collection to genomic analysis.
- Post-Test Clinical Interpretation – A DHA licensed Consultant Medical Geneticist provides a telephonic results discussion and family counselling roadmap within 21 calendar days of sample receipt.
- Insurance Pre-Approval & Direct Billing – Confirm coverage instantly via WhatsApp at +971 54 548 8731. Transparent pricing with no hidden charges.
Test Overview & Methodology
This comprehensive NGS based single-gene assay decodes the entire ALDH3A2 gene, detecting pathogenic variants responsible for Sjögren-Larsson syndrome (SLS). SLS is a rare autosomal recessive neurocutaneous disorder characterised by congenital ichthyosis, spastic diplegia, intellectual disability, and a distinctive retinopathy. Early molecular confirmation is critical for initiating multidisciplinary management including physiotherapy, ophthalmological surveillance, and dermatological care. The analysis covers all exons plus 10 base pairs of flanking intronic sequence, providing full gene coverage with a mean read depth exceeding 100×.
| Feature | DNA Labs UAE Comprehensive NGS | Standard Targeted Panel |
|---|---|---|
| Detection Scope | Whole gene sequencing (coding exons + flanking introns + 5′/3′ UTR) | Limited hotspot mutation panel |
| Sequencing Technology | Illumina® NGS with 150 bp paired-end reads, bioinformatics verified | Sanger sequencing or PCR based targeted genotyping |
| Turnaround Time | 3 weeks (expedited 10 day option available on request) | 6 to 8 weeks (batch processing) |
| UAE Regulatory Compliance | DHA licensed facility (License No. 1143), PDPL compliant, ISO 9001:2015 certified | May lack local licensure or insurance pre-approval pathways |
Physician Insight & Safety Protocols
“When a young child presents with a triad of scaly skin from birth, delayed motor milestones, and spasticity, the clinical suspicion for Sjögren-Larsson syndrome is high. This ALDH3A2 NGS test provides definitive molecular confirmation when clinical features are suggestive. However, I must emphasise that a genetic diagnosis does not replace a comprehensive neurological and dermatological assessment. The result must be integrated into a complete clinical picture before any therapeutic decisions are made. Families should always consult their treating paediatric neurologist or genetic counsellor before drawing conclusions from this report.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Protocols & Patient Eligibility
Pre-Procedure Advisory
A mandatory pre-test genetic counselling session is required prior to blood draw. This telephonic or in-person consultation documents your family pedigree, explains the scope of results, and secures informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. No fasting is necessary, but you must disclose all current medications (especially anticoagulants such as warfarin or heparin) and any blood transfusions received within the preceding 4 weeks.
Safety Exclusion Criteria & Urgent Clinical Warnings
- Active febrile illness or systemic infection – postpone blood draw until full recovery is confirmed.
- Therapeutic anticoagulation therapy – inform the phlebotomist; special post-draw pressure and monitoring required.
- Blood transfusion within the last 4 weeks – may compromise DNA yield and purity; reschedule accordingly.
- For minor patients (under 18 years), written legal guardian consent is mandatory per UAE Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
🚨 Seek emergency medical attention immediately if the patient experiences sudden onset vision loss, refractory seizures, rapid escalation of spasticity, or respiratory compromise. These symptoms may indicate neurological progression of the underlying condition and are not related to the blood draw procedure.
Patient FAQ & Clinical Guidance
1. What does the ALDH3A2 gene test detect and how will it impact my care plan?
This NGS assay identifies disease-causing variants across the full ALDH3A2 gene, confirming or excluding a clinical diagnosis of Sjögren-Larsson syndrome with 99.9% sensitivity. A positive result enables your neurologist and dermatologist to implement targeted interventions such as early physiotherapy, regular ophthalmological screening for retinopathy, and retinoid-based ichthyosis management. The result also provides recurrence risk information for family planning.
2. How do I prepare for the blood collection and what happens during the home visit?
A standard venous blood draw (3-5 mL in EDTA tube) is performed at your residence by our certified phlebotomist. No fasting or special dietary preparation is required. The pre-test genetic counselling session (mandatory) will be scheduled 24-48 hours before the draw to review your family history and obtain informed consent. Please have your Emirates ID and any prior medical records ready. The phlebotomist carries temperature-monitored transport containers to ensure specimen stability.
3. Is my genetic data protected under UAE privacy laws?
Yes, your genomic data and personal health information are fully protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). All DNA sequence data is stored on encrypted servers located within the UAE and is accessible only to the authorised ordering physician and the laboratory genetics team. Results are released solely to you and your designated healthcare provider; no third-party access is granted without your explicit written consent.
4. How long does it take to get results and how will I receive them?
The standard turnaround time is 21 calendar days from sample receipt at our laboratory. An expedited 10-day service is available on request. Results are delivered via a secure patient portal and a telephonic consultation with our Consultant Medical Geneticist, who will explain the findings, discuss implications, and coordinate referrals to specialists as needed.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Data Protection: All genetic data is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). Encrypted storage, access controls, and consent-based data sharing protocols are enforced.
- Health Information Security: Full adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring that electronic health records and genomic data are transmitted and stored using UAE-approved cybersecurity standards.
- Medical Liability & Patient Consent: Informed consent for genetic testing is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability, safeguarding patient rights and ensuring transparent pre-test counselling.
- Laboratory Accreditation: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and fully licensed by the Dubai Health Authority (Facility License No. 1143).
Clinical & Logistical Metadata
| Test Name | ALDH3A2 Gene Sequencing – Sjögren-Larsson Syndrome Genetic Test |
| Price (AED) | 2,800 AED (includes pre-test counselling, phlebotomy, NGS analysis, and post-test physician consultation) |
| Turnaround Time | 21 calendar days (standard) / 10 calendar days (expedited with surcharge) |
| Sample Type / Matrix | Peripheral whole blood (3-5 mL in EDTA vacutainer) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina® platform, paired-end 150 bp reads, mean coverage >100×, bioinformatics variant calling with GATK best practices |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 55233-1 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians