Test Price
2,800 AED✅ Home Collection Available
ADNP Gene Genetic Test for Mental Retardation (Autosomal Dominant Type 28) in UAE – 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity for ADNP variants via ISO accredited targeted NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test result interpretation with a consultant medical geneticist.
- Insurance Verification: Direct billing inquiry via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced next-generation sequencing (NGS) test analyzes the entire coding region of the ADNP gene to detect pathogenic variants causing autosomal dominant mental retardation type 28 (Helsmoortel‑van der Aa syndrome). The test provides a definitive molecular diagnosis with high clinical sensitivity, enabling targeted management and family counselling.
| Feature | Our Test (NGS ADNP) | Closest Alternative (Whole Exome) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for ADNP variants, deep intronic coverage | ~95% for coding variants, limited intronic analysis |
| Methodology | Targeted NGS with full exon and intron-border sequencing | Whole exome sequencing (WES) – broader but shallower |
| Turnaround Time | 3–4 weeks (focused analysis) | 6–10 weeks (complex data interpretation) |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I stress that a genetic diagnosis must always be interpreted alongside the patient’s developmental history and family pedigree. This test provides clarity for families seeking answers about intellectual disability, but it does not replace a comprehensive neurodevelopmental assessment. I advise discussing all results with a specialist before initiating any therapeutic interventions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medical Advisory
Do not discontinue or alter any prescribed medication, therapy, or intervention based solely on this genetic test result without consulting your treating physician or genetic specialist. The information provided is for diagnostic guidance and should be used in conjunction with clinical evaluation.
Exclusion Criteria & Emergency Red Flags
- Acute febrile illness or unstable clinical condition – postpone blood draw until resolved.
- Inability to provide adequate venous access – consult alternative sample collection.
- For minors: mandatory pre‑test genetic counselling as per UAE Federal Law No. 2 of 2019 on Use of ICT in Health Fields.
- Seek immediate medical attention if: sudden loss of developmental skills, new‑onset seizures, or severe behavioural regression after receiving results.
Patient FAQ & Clinical Guidance
1. What is the ADNP gene test and who should consider it?
This NGS test identifies pathogenic variants in the ADNP gene, providing a definitive molecular diagnosis for autosomal dominant intellectual disability with high clinical sensitivity. It is recommended for children and adults with unexplained developmental delay, autism spectrum features, distinctive facial dysmorphisms, or a family history suggestive of ADNP‑related disorder. Neurologists, clinical geneticists, and paediatricians commonly order this test after a thorough clinical evaluation and genetic counselling, which is mandatory under UAE regulations (Federal Law No. 2 of 2019).
2. How accurate is the test and what does a negative result mean?
Our targeted NGS achieves >99.9% analytical sensitivity and specificity for single nucleotide variants and small indels within the ADNP coding region, nearly eliminating false negatives. A negative report significantly reduces the likelihood of ADNP‑related disorder, but does not exclude rare deep intronic alterations or large deletions not covered by current probes. In such cases, additional genetic testing (e.g., chromosomal microarray) may be warranted. All findings are interpreted according to ACMG guidelines and correlated with clinical phenotype.
3. How is the home collection arranged and is my data protected under UAE law?
A certified phlebotomist visits your home between 8 AM and 11 PM with full cold‑chain logistics, ensuring sample integrity while maintaining complete privacy and data security. Schedule collection via WhatsApp at +971 54 548 8731. All procedures comply with the UAE Personal Data Protection Law (Federal Decree‑Law No. 45 of 2021) and Federal Law No. 2 of 2019. Your genetic information is stored in an encrypted, ISO 9001:2015‑certified database and never shared without explicit consent, except as mandated by law for public health reporting.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates under the regulatory oversight of the Dubai Health Authority (DHA) and complies with all applicable UAE federal laws. Patient data is handled in strict accordance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical governance and patient safety are aligned with Federal Decree‑Law No. 4 of 2016 on Medical Liability. All laboratory processes are ISO 15189 accredited and subject to regular audit.
Clinical & Logistical Metadata
| Test Name | ADNP Gene Genetic Test for Mental Retardation (Autosomal Dominant Type 28) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA tube) |
| Methodology Used | Targeted Next-Generation Sequencing (NGS) – full coding region and intron‑exon boundaries |
| ICD-10-CM Code | F79 (Unspecified intellectual disabilities) |
| LOINC Code | 91847-4 (Gene targeted sequencing) |
| DHA Facility License & Laboratory Address | Facility License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians