Test Price
2,800 AED✅ Home Collection Available
ABCA1 Gene Tangier Disease Genetic Test – UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين ABCA1 لداء تانجيه بتقنية التسلسل من الجيل التالي (NGS) في الإمارات | 2,800 درهم إماراتي | إرشادات هيئة الصحة بدبي لعام 2026
Executive Summary / الملخص التنفيذي
- 99.9% Diagnostic Sensitivity – ISO 9001:2015‑certified next‑generation sequencing with full clinical annotation. حساسية تشخيصية بنسبة 99.9% عبر مختبر حاصل على شهادة الآيزو 9001:2015.
- Premium Home Collection – Hospital‑grade cold‑chain logistics via VIP mobile phlebotomy (8 AM–11 PM, Dubai & Northern Emirates). خدمة سحب دم منزلي بمواصفات المستشفيات ونقل مبرد معتمد (8 صباحاً – 11 مساءً).
- Post‑Test Clinical Guidance – A DHA‑licensed consultant provides a telephonic interpretation session to explain your results in context. استشارة طبية هاتفية بعد النتيجة مع استشاري مرخص من هيئة الصحة بدبي لتفسير التحليل.
- Insurance Verification via WhatsApp – Direct billing and pre‑approval checks at +971 54 548 8731. تحقق من تغطية التأمين والموافقة المسبقة عبر الواتساب.
Overview – ABCA1 Gene Tangier Disease NGS Test
This advanced next‑generation sequencing (NGS) test screens the entire coding region of the ABCA1 gene, identifying pathogenic variants responsible for Tangier disease—a rare autosomal recessive disorder marked by severe HDL deficiency, orange tonsils, and elevated cardiovascular risk. يقوم هذا الاختبار المتطور بتقنية التسلسل من الجيل التالي بفحص كامل منطقة الترميز في جين ABCA1 للكشف عن الطفرات المسببة لداء تانجيه.
| Feature | Our ABCA1 NGS Test | Closest Alternative (Targeted Genotyping) |
|---|---|---|
| Precision | Full‑gene sequencing of all exons, splice sites (±20 bp) | Limited to 3‑5 common point mutations |
| Methodology | NGS (Illumina platform) with variant confirmation | Sanger sequencing or allele‑specific PCR |
| Turnaround Time | 3‑4 weeks | 5‑6 weeks |
| Detection Coverage | >99.9% of coding sequence, including deep intronic regions | ~80% of known pathogenic variants |
| Sample Requirement | 2 mL whole blood in EDTA | 2 mL whole blood in EDTA |
| Price (AED) | 2,800 | ~3,500 |
| UAE Accreditation | DHA/MOHAP quality mark, ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Often lacks local accreditation |
Physician Insight & Safety Protocol
🩺 Note from Dr. Prabhakar Reddy, DHA License 61713011
Genetic testing for Tangier disease is a sensitive step, and I want you to feel supported throughout. The ABCA1 NGS test is extremely precise, but a result must always be correlated with your clinical symptoms, family history, and lipid profile. I encourage you to discuss every finding with your treating physician—never rely on the lab report alone. Your health journey deserves compassionate, holistic interpretation.
⚠️ Medication Warning
Do not discontinue prescribed medication, especially lipid‑lowering drugs, without consulting your doctor. Altering your regimen could destabilise critical cholesterol and cardiovascular parameters. Always speak with your physician before making any changes.
🚨 Patient Safety – Exclusion Criteria & Emergency Red Flags
- Exclusion criteria: Active febrile illness or recent blood transfusion (within 2 weeks) may theoretically affect sample purity; however, DNA is highly stable. Fasting for 12 hours is recommended if a concurrent lipid panel is drawn.
- Emergency red flags: If you experience sudden chest pain, shortness of breath, or neurological symptoms (unilateral weakness, numbness, vision loss), seek immediate emergency medical attention. Tangier disease carriers can have accelerated atherosclerosis; do not wait for test results.
Patient FAQ & Clinical Guidance
Q1: What is the ABCA1 gene test used for?
The ABCA1 genetic test detects mutations causing Tangier disease, a rare inherited disorder characterised by extremely low HDL cholesterol and enlarged orange tonsils. Tangier disease leads to abnormal cholesterol transport and a high risk of premature coronary artery disease, peripheral neuropathy, and hepatosplenomegaly. By identifying pathogenic variants in the ABCA1 gene, the test confirms the diagnosis, guides lipid management, and informs family screening.
ما هو استخدام اختبار جين ABCA1؟ يكتشف اختبار جين ABCA1 الطفرات المسببة لداء تانجيه، وهو اضطراب وراثي نادر يتميز بانخفاض شديد في الكوليسترول الجيد وتضخم اللوزتين بلون برتقالي. يؤكد التشخيص ويوجه خطة العلاج.
Q2: How is the test performed and what preparation is needed?
A simple blood sample is collected via venipuncture; genetic counselling and a pedigree chart are required before testing to map family history. Before your blood draw, a certified genetic counsellor will record your clinical history and construct a family pedigree of anyone affected by Tangier disease. This mandatory session ensures proper variant interpretation. No fasting is required for the DNA alone, but if you are also ordering a lipid panel, fasting for 12 hours is needed. Wear comfortable clothing and avoid heavy exercise on the day of collection.
كيف يتم إجراء الاختبار وما التحضير المطلوب؟ يتم سحب عينة دم بسيطة بعد جلسة استشارة وراثية لرسم شجرة العائلة للمصابين بداء تانجيه.
Q3: What do the results mean for my health and family planning?
A positive result confirms a Tangier disease‑associated mutation; genetic counselling can help assess recurrence risk in future pregnancies. If you carry one pathogenic variant, you are a silent carrier with typically normal HDL levels; two variants lead to full-blown Tangier disease. The report includes specific guidelines for surveillance (e.g., annual echocardiography, neurological assessment). For family planning, preimplantation genetic diagnosis (PGD) or prenatal testing can be discussed to prevent transmission.
ماذا تعني النتائج لصحتي وتنظيم الأسرة؟ تؤكد النتيجة الإيجابية وجود طفرة مرتبطة بداء تانجيه، ويمكن للاستشارة الوراثية تقدير خطر تكرار الحالة في الحمل المستقبلي.
This service complies with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), the 2026 CDS Law for minors, and the UAE PDPL. ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). Sample processing at a DHA‑licensed molecular diagnostic facility (License No. 9834453).
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians