Test Price
2,800 AED✅ Home Collection Available
WNT3 Gene Tetra‑Amelia, Autosomal Recessive Genetic Test in UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO‑accredited next‑generation sequencing workflow.
- Turnaround Time: Definitive clinical report within 3–4 weeks from sample receipt.
- Collection Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily 8 AM – 11 PM.
- Clinical Support: Post‑test telephonic genetic counselling to integrate results into personalised care planning.
- Insurance Verification: Direct benefit confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next‑generation sequencing (NGS) assay interrogates the entire coding region and splice‑site boundaries of the WNT3 gene to detect autosomal recessive pathogenic variants responsible for tetra‑amelia syndrome — a rare congenital disorder characterised by the complete absence of all four limbs. The test delivers definitive molecular diagnosis, accurate carrier screening, and evidence‑based guidance for family planning and prenatal counselling.
Pre‑test Requirements: A comprehensive clinical history capturing the patient‘s phenotype and family pedigree is mandatory. A dedicated genetic counselling session must be completed prior to sample collection to construct a validated three‑generation pedigree documenting any relatives affected by tetra‑amelia syndrome or WNT3‑related anomalies. No dietary modifications, fasting, or medication adjustments are required specifically for this genetic test; continue all prescribed therapies as directed by your physician.
| Feature | Our NGS Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity, full gene coverage including intronic boundaries | Sanger sequencing of selected exons only, limited mutation spectrum |
| Methodology | Next‑Generation Sequencing (NGS) with advanced bioinformatics pipeline | Capillary electrophoresis, manual variant calling |
| Turnaround Speed | 3–4 weeks; comprehensive clinical report with variant classification | Often 6–8 weeks, fragmented reporting without integrated counselling |
Physician Insight & Safety Protocols
“WNT3 gene analysis by NGS provides definitive molecular confirmation of tetra‑amelia syndrome, enabling precise carrier detection and informed family planning. However, clinical presentation may show variability; correlation with prenatal imaging and multidisciplinary evaluation remains essential for comprehensive patient management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Continue all prescribed medications as directed by your treating physician. Do not alter or discontinue any therapeutic regimen without explicit consultation with your healthcare provider.
Safety Exclusion Criteria & ER Red Flags
Contraindications for Sample Collection
- Acute febrile illness or unstable medical condition that precludes safe venepuncture.
- Inability to provide informed consent or absence of parental/guardian consent for minors.
- Known severe coagulopathy or undisclosed anticoagulant therapy.
- Seek immediate emergency care if you experience severe bleeding, syncope, signs of infection (erythema, swelling, warmth), or an allergic reaction following sample collection.
Patient FAQ & Clinical Guidance
1. What makes this NGS WNT3 test more reliable than traditional genetic testing?
This assay employs next‑generation sequencing to analyse the entire WNT3 coding region and splice‑site junctions with >99% analytical sensitivity, detecting rare pathogenic variants that may be missed by Sanger sequencing or targeted exon analysis. The bioinformatics pipeline classifies variants according to ACMG/AMP guidelines, ensuring robust and reproducible results.
2. How should I prepare for the blood or DNA sample collection?
No fasting is required. Avoid strenuous physical activity for two hours prior to collection and inform the phlebotomist about any bleeding disorders, anticoagulant use, or history of vasovagal episodes. Your sample will be collected by a trained mobile phlebotomist under sterile conditions and transported via temperature‑controlled cold chain.
3. How will my genetic results be protected under UAE law?
Your genetic data is safeguarded under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All data is processed, stored, and transmitted using encryption and anonymisation protocols compliant with UAE healthcare regulations.
4. Will I receive genetic counselling after the test?
Yes, a telephonic consultation with a qualified genetic counsellor is included in the service to help you understand your results, discuss inheritance patterns, and coordinate referrals to paediatric, orthopaedic, or reproductive specialists as needed.
UAE Regulatory & Data Privacy Adherence
Legal Mandates & Accreditation
- Clinical testing and patient consent governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Data privacy and security compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information governance adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139).
- Insurance and billing support via phone/WhatsApp: +971 54 548 8731 — direct verification available.
Clinical & Logistical Metadata
| Test Name | WNT3 Gene Tetra‑Amelia, Autosomal Recessive – NGS Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or extracted genomic DNA |
| Methodology Used | Next‑Generation Sequencing (NGS) with full gene coverage and bioinformatics variant classification |
| ICD-10-CM Code | Q73.1 |
| LOINC Code | 82903-4 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians