Test Price
2,800 AED✅ Home Collection Available
TGM5 Gene (Peeling Skin Syndrome Type 2) Genetic Test in UAE
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% sensitivity via ISO-certified NGS processing.
- Concierge Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily, 8 AM – 11 PM).
- Clinical Guidance: Complimentary post-test telephone consultation with a Consultant Medical Geneticist for result interpretation.
- Insurance Verification: Direct billing and insurance pre-verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TGM5 Gene Genetic Test utilizes advanced Next-Generation Sequencing (NGS) to identify pathogenic variants in the TGM5 gene. This test confirms a diagnosis of Peeling Skin Syndrome Type 2, a rare autosomal recessive genodermatosis characterized by lifelong superficial skin peeling. In the UAE, DNA Labs UAE offers this test with a comprehensive turnaround time of 21 to 28 days, complemented by ISO-certified cold-chain logistics for home sample collection.
Our full-gene sequencing approach covers all coding regions, intron-exon boundaries, and enables copy number variation (CNV) detection, ensuring the highest diagnostic yield compared to standard targeted genotyping.
| Feature | Our NGS Panel (Full Gene Sequencing & CNV Analysis) | Standard Targeted Mutation Genotyping |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity; detects all variants including novel mutations | 85–90% sensitivity; limited to predefined hotspots |
| Methodology | NGS with coverage of entire coding region, intron-exon boundaries, and CNV calling | PCR and Sanger sequencing of specific exons only |
| Turnaround Time | 21–28 Days | 14–21 Days |
| Clinical Utility | Definitive diagnosis, family screening, and reproductive risk assessment | Presumptive confirmation in known familial mutation context |
Physician Insight & Safety Protocols
"This comprehensive NGS analysis for the TGM5 gene is a cornerstone for diagnosing Peeling Skin Syndrome Type 2. It provides the molecular clarity needed to differentiate this condition from other ichthyoses, guiding accurate genetic counseling and family planning. A positive result offers a definitive diagnosis, but it must be contextualized within a complete dermatological and familial assessment to optimize patient care."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Safety Precautions
- This test is suitable for individuals with clinical suspicion of Peeling Skin Syndrome Type 2 or a known family history.
- Patients with active febrile illness should reschedule sample collection until fully recovered.
- If you experience severe dizziness, syncope, or prolonged bleeding post-collection, seek immediate medical attention.
- Do not discontinue any prescribed medication without prior consultation with your treating physician.
Contraindications & Exclusions
- This test is not intended for prenatal diagnosis or carrier screening in isolation without prior genetic counseling.
- Individuals with a known allergy to lidocaine or adhesive dressings should inform the phlebotomist prior to collection.
- Results are for diagnostic confirmation and should not be used as a standalone measure for treatment decisions.
Patient FAQ & Clinical Guidance
1. What does the TGM5 gene genetic test diagnose?
This test detects disease-causing mutations in the TGM5 gene to confirm a diagnosis of Peeling Skin Syndrome Type 2, a rare inherited skin disorder. It provides definitive molecular evidence to distinguish this condition from other blistering or scaling dermatoses, facilitating precise genetic counseling and reproductive risk assessment.
2. How is the sample collected, and is home service available in the UAE?
A certified phlebotomist from DNA Labs UAE collects a standard peripheral blood sample during a VIP home visit. The service operates daily from 8 AM to 11 PM, utilizing temperature-controlled cold-chain logistics to maintain DNA integrity. This fully compliant mobile service eliminates the need for hospital visits for most patients across Dubai and the UAE.
3. What preparation is required before the TGM5 genetic test?
No fasting or alterations to your medication routine are necessary. You will be required to provide a detailed clinical and family history during a mandatory pre-test genetic counseling session. This session ensures the test is interpreted accurately within your specific health and familial context, aligning with DHA clinical practice guidelines.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Governance
DNA Labs UAE strictly adheres to the UAE's federal data protection and healthcare regulatory frameworks. All genetic testing and associated data processing are conducted in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient information is encrypted, anonymized for research purposes (with consent), and processed within secure UAE-based servers, ensuring complete confidentiality and compliance with DHA standards.
Clinical & Logistical Metadata
| Test Name | TGM5 Gene (Peeling Skin Syndrome Type 2) Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21 – 28 Days |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Analysis |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 82162-7 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians