Test Price
2,800 AED✅ Home Collection Available
PRPS1 Gene (Arts Syndrome) Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 17025 & ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation in English by a UAE-licensed geneticist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The PRPS1 NGS test sequences the entire coding region of the PRPS1 gene to detect pathogenic variants responsible for Arts syndrome, an X‑linked disorder causing sensorineural hearing loss, ataxia, and optic atrophy. This UAE‑compliant assay provides a definitive molecular diagnosis that guides neurology and genetics management.
| Feature | Our PRPS1 NGS Test | Closest Alternative (Sanger Single‑Exon) |
|---|---|---|
| Precision | Full gene coverage (all exons ±10 bp intronic boundaries) | Limited to a single hotspot exon; misses deep intronic mutations |
| Methodology | Next‑Generation Sequencing (NGS) with confirmatory Sanger backup | Only Sanger sequencing; lower sensitivity for low‑level mosaicism |
| Turnaround Time | 3–4 weeks | 5–8 weeks |
Physician Insight & Safety Protocols
A Word from Dr. Lina Osama Zaki Quteineh (DHA Registration ID: 9294403)
“This advanced NGS assay provides a definitive molecular diagnosis for Arts syndrome when clinical findings are inconclusive. However, a negative result does not rule out other genetic or acquired neurological disorders. The report must be correlated with full clinical workup, audiometry, and neuroimaging. Genetic counselling is mandatory before testing to discuss X‑linked inheritance and implications for at‑risk family members.”
⚠️ Medication Advisory
Do not discontinue any prescribed medication without consulting your treating physician. Stopping anti‑seizure drugs or other neurological treatments may cause serious withdrawal effects. Only your specialist should adjust therapy based on genetic findings.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: We cannot process samples without a signed DHA‑compliant Genetic Test Consent Form in accordance with Federal Decree‑Law No. 4 of 2016 on Medical Liability. Minors require additional parental consent. Patients with active haemolysis or recent blood transfusion should delay collection for at least 2 weeks.
- ER Red Flags – Seek immediate medical care if you experience:
- Sudden, profound hearing loss or acute vision decline.
- New‑onset seizures or unexplained loss of consciousness.
- Severe ataxia leading to falls or inability to walk.
Patient FAQ & Clinical Guidance
1. How long does it take to get the PRPS1 Arts syndrome test result, and what does a positive result mean?
Result integration and confirmatory analysis takes 3–4 weeks, delivering a clinician‑ready report covering variant classification. A positive (pathogenic) PRPS1 variant confirms Arts syndrome at the molecular level, allowing the neurology team to tailor hearing rehabilitation, physiotherapy, and genetic counselling for X‑linked inheritance. However, clinical correlation remains essential because disease severity can vary even within the same family.
2. Is genetic counselling mandatory before this test?
Under UAE Federal Decree‑Law No. 4 of 2016, a DHA‑certified pre‑test genetic counselling session is compulsory for all predictive and diagnostic genetic tests. The session includes constructing a three‑generation pedigree chart, explaining the X‑linked inheritance pattern, and documenting informed consent. This step safeguards your rights and ensures the test is ordered appropriately.
3. Can an adult undergo the test without informing family members?
Under the UAE Personal Data Protection Law (PDPL) and medical privacy regulations, every competent adult can undergo genetic testing without notifying relatives, although genetic counselling will encourage voluntary sharing. The result is never forced upon family members without your consent; however, voluntary disclosure helps early detection in at‑risk relatives. The laboratory adheres to strict confidentiality and does not share data with third parties without your explicit authorization.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
- Data Privacy: All genetic data is processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Security: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields ensures end‑to‑end encryption of patient records.
- Medical Liability & Consent: Pre‑test genetic counselling and informed consent are conducted as per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Accreditations: ISO 9001:2015 Certified (Cert No: INT/EGQ/2509DA/3139). All processing occurs in DHA‑licensed, UAE‑sovereign facilities.
Clinical & Logistical Metadata
| Test Name | PRPS1 Gene (Arts Syndrome) – Full Gene Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (2–5 mL in EDTA tube) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 88552-8 |
| DHA Facility License & Laboratory Address Invariants | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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