Test Price
2,800 AED✅ Home Collection Available
PRPS1 Gene (Arts Syndrome) Genetic Test in UAE | AED 2,800 | 2026 DHA Guidelines
تحليل الجين PRPS1 لمتلازمة آرتس في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | الملخص التنفيذي
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 17025 & ISO 9001:2015 Accredited Processing.
دقة تشخيصية 99.9% عبر مختبر معتمد بتقنيات التسلسل الجيني الحديثة. - Premium Logistics: Hospital-Grade Home Collection with ISO Certified Cold-Chain and VIP Mobile Phlebotomy.
سحب عينات منزلي بدرجة حرارة مراقبة وشحن مبرد وفقًا لمعايير الآيزو. - Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation in Arabic and English.
استشارة هاتفية مجانية بعد النتيجة لشرح التقرير الجيني. - Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Overview
The PRPS1 NGS test sequences the entire coding region of the PRPS1 gene to detect pathogenic variants responsible for Arts syndrome, an X‑linked disorder causing sensorineural hearing loss, ataxia, and optic atrophy. This UAE‑compliant assay provides a definitive molecular diagnosis that guides neurology and genetics management.
يقوم اختبار التسلسل الجيني الكامل لجين PRPS1 بالكشف عن الطفرات المسببة لمتلازمة آرتس المرتبطة بالكروموسوم X، مما يمكّن أطباء الأعصاب والوراثة من وضع خطة علاجية دقيقة.
| Feature | Our PRPS1 NGS Test | Closest Alternative (Sanger Single‑Exon) |
|---|---|---|
| Precision | Full gene coverage (all exons ±10 bp intronic boundaries) | Limited to a single hotspot exon; misses deep intronic mutations |
| Methodology | Next‑Generation Sequencing (NGS) with confirmatory Sanger backup | Only Sanger sequencing; lower sensitivity for low‑level mosaicism |
| Turnaround Time | 3–4 weeks | 5–8 weeks |
Physician Insight & Safety Protocol
A Word from Dr. PRABHAKAR REDDY (DHA License 61713011)
“This advanced NGS assay can finally pinpoint the genetic aetiology of Arts syndrome when clinical signs are ambiguous. However, a negative result does not completely exclude other genetic or acquired neurological conditions, and the report must be interpreted alongside a full clinical evaluation, brain imaging, and audiometry. Genetic counselling is mandatory before sampling to ensure families understand the X‑linked inheritance and the implications for at‑risk relatives.”
⚠️ Medication Warning:
Do not discontinue any prescribed medication without consulting your treating physician. Discontinuation of anti‑seizure drugs, corticosteroids, or other neurological medications can precipitate serious withdrawal effects. Only your specialist can adjust therapy based on the genetic test outcome.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: We cannot process samples without a signed DHA‑compliant Genetic Test Consent Form (Federal Decree‑Law No. 41 of 2024, Art. 87). Minors require additional parental consent per UAE Child Protection Law (CDS 2026). Patients with active haemolysis or very recent blood transfusion should delay collection.
- ER Red Flags – Seek immediate medical care if you experience:
- Sudden, profound hearing loss or acute vision decline.
- New‑onset seizures or unexplained loss of consciousness.
- Severe ataxia leading to falls or inability to walk.
Patient FAQ & Clinical Guidance
1. How long does it take to get the PRPS1 Arts syndrome test result, and what does a positive result mean?
Result integration and confirmatory analysis takes 3–4 weeks, delivering a clinician‑ready report covering variant classification. A positive (pathogenic) PRPS1 variant confirms Arts syndrome at the molecular level, allowing the neurology team to tailor hearing rehabilitation, physiotherapy, and genetic counselling for X‑linked inheritance. However, clinical correlation remains essential because disease severity can vary even within the same family.
2. Is genetic counselling mandatory before this test?
Under UAE Federal Decree‑Law No. 41 of 2024, a DHA‑certified pre‑test genetic counselling session is compulsory for all predictive and diagnostic genetic tests. The session includes constructing a three‑generation pedigree chart, explaining the X‑linked inheritance pattern, and documenting informed consent. This step safeguards your rights and ensures the is ordered appropriately.
3. هل يمكن لشخص بالغ إجراء الاختبار دون إبلاغ أفراد العائلة؟
وفقًا لقانون حماية البيانات الشخصية الإماراتي (UAE PDPL) وقانون الخصوصية الطبية، يحق لكل فرد بالغ إجراء الاختبارات الجينية دون إبلاغ الأقارب، لكن الاستشارة الوراثية ستشجعك على مشاركة النتيجة. النتيجة لا تُفرض على أفراد العائلة ضد إرادتك، ولكن التواصل الطوعي يساعد في الكشف المبكر عن الحالات الوراثية لدى المعرضين للخطر. يلتزم المختبر بالسرية التامة ولا يشارك البيانات مع أي طرف ثالث دون موافقتك الصريحة.
English: “Under the UAE Personal Data Protection Law (PDPL), every competent adult can undergo genetic testing without notifying relatives, although genetic counselling will encourage voluntary sharing. The result is never forced upon family members without your consent; however, voluntary disclosure helps early detection in at‑risk relatives. The laboratory adheres to strict confidentiality and does not share data with third parties without your explicit authorization.”
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Available in Arabic, English, Hindi & Urdu
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