Test Price
2,800 AED✅ Home Collection Available
NOD2 Gene Blau Syndrome Genetic Test in UAE | 2800 AED | DHA Accredited
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Sequencing. Premium cold-chain home collection, VIP mobile phlebotomy (8 AM–11 PM), and telephonic post-test clinical guidance by a DHA-licensed consultant medical geneticist. Direct billing verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The NOD2 Gene Blau Syndrome NGS Test assesses the entire coding region of the NOD2 (CARD15) gene using next-generation sequencing to detect pathogenic variants associated with Blau syndrome—a rare autosomal dominant autoinflammatory disorder characterized by granulomatous arthritis, uveitis, and dermatitis. This test provides comprehensive coverage including copy number variant detection, confirmed by Sanger sequencing as needed.
| Feature | Our NOD2 NGS Test (UAE) | Conventional Single-Gene Sanger Sequencing |
|---|---|---|
| Precision | Full gene coverage with copy number variant detection | Limited to targeted hot-spot regions |
| Methodology | NGS + Sanger confirmation (LC‑MS/MS not applicable) | Sanger only |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Report | Interpretation by DHA-licensed consultant medical geneticist | Basic variant listing |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (DHA Registration ID: 9294403) – Consultant Medical Genetics: “A positive NOD2 variant confirms the diagnosis of Blau syndrome but must be correlated with clinical findings such as early-onset granulomatous arthritis and uveitis. This test provides families with reproductive risk assessment, yet no result replaces a comprehensive clinical evaluation.”
Medication Advisory
Do not discontinue prescribed medications (e.g., corticosteroids, biologics) without consulting your treating physician. Abrupt cessation may provoke severe inflammatory flares.
Exclusion Criteria & Red Flags
- Active infection requiring intravenous antibiotics at time of sample collection.
- Known interfering substances: Recent blood transfusion (<4 weeks) may affect germline variant detection in DNA extracted from whole blood.
- Emergency symptoms: Acute vision loss, severe joint pain with systemic signs—seek immediate medical care, not elective genetic testing.
Patient FAQ & Clinical Guidance
1. How accurate is the NOD2 NGS test for Blau syndrome, and can it rule out other autoinflammatory diseases?
This NGS delivers 99.9% analytical sensitivity for nucleotide-level variants in the NOD2 gene. However, Blau syndrome is genetically heterogeneous; a negative result does not exclude NLRP3-related or other autoinflammatory syndromes. Clinical correlation is essential.
2. What sample types are accepted and how should I prepare for home collection?
Accepted samples include whole blood (3–5 mL in EDTA tube), extracted DNA, or dried blood spot on FTA card. No fasting is required. Please inform our phlebotomist about any recent blood transfusions, as this may affect DNA quality.
3. Can this test be performed on a child under 18 years of age?
Yes, with written parental consent and pre-test genetic counseling as mandated by UAE Federal Law No. 2 of 2019 and the Medical Liability Law (Federal Decree-Law No. 4 of 2016). Our consultant medical geneticist will guide the family through the process.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is stored on UAE-based servers and never shared without explicit patient consent. Testing is performed under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). DHA Facility License: 1143, Laboratory Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab Branding: DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | NOD2 Gene Blau Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | M04.8 |
| LOINC Code | 77774-9 |
| DHA Facility License & Laboratory Address | Facility License: 1143; Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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