Test Price
2,800 AED✅ Home Collection Available
MARS2 Gene Combined Oxidative Phosphorylation Deficiency Type 25 (COXPD25) Genetic Test in UAE – 2800 AED – DHA Licensed
Executive Summary & Core Metrics
The MARS2 Gene NGS Test detects pathogenic variants causing Combined Oxidative Phosphorylation Deficiency Type 25 (COXPD25), a rare autosomal recessive mitochondrial disorder. This test employs Next-Generation Sequencing to provide definitive molecular confirmation, essential for guiding metabolic and neurological management. The analysis is performed in an ISO 9001:2015 accredited laboratory with 99.9% diagnostic sensitivity. Results are delivered within 18 working days (3–4 weeks), accompanied by post-test genetic counselling with a DHA-licensed consultant.
- ● Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Laboratory.
- ● Premium Logistics: Hospital-Grade Home Collection with ISO Certified Cold-Chain and VIP Mobile Phlebotomy (8 AM – 11 PM).
- ● Clinical Guidance: Post‑test telephonic interpretation with DHA‑licensed genetic counsellors.
- ● Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MARS2 Gene NGS Test sequences the entire coding region of the MARS2 gene using next-generation sequencing (Illumina platform). This method provides whole-gene coverage with variant-level resolution, enabling detection of single nucleotide variants, small insertions/deletions, and splice-site mutations. The test is ordered when clinical symptoms such as lactic acidosis, hypotonia, and multisystem involvement suggest mitochondrial disease, or when family history warrants carrier screening. Pre-test genetic counselling with pedigree chart is required prior to sample submission.
| Feature | Our Test (MARS2 NGS) | Closest Alternative |
|---|---|---|
| Precision | Whole‑gene coverage, variant‑level resolution | Sanger sequencing of selected exons only |
| Method | NGS (Illumina platform, ISO 9001:2015) | Conventional PCR‑based fragment analysis |
| Turnaround | 3–4 Weeks (average 18 days) | 4–6 Weeks |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I emphasise that a positive MARS2 mutation indicates a genetic predisposition to oxidative phosphorylation deficiency. However, this result must be integrated with biochemical profiles, neuroimaging, and three-generation family history. Genetic counselling is mandatory before and after testing to interpret variant pathogenicity, recurrence risks, and potential therapeutic options. Do not alter any current treatment without full clinical correlation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication and Supplement Safety
⚠ Do not discontinue prescribed medications or supplements without consulting your managing physician.
Mitochondrial supportive therapies, including coenzyme Q10, riboflavin, and L-carnitine, require careful, supervised tapering. Sudden cessation may precipitate metabolic decompensation in susceptible individuals.
Exclusion Criteria and Emergency Red Flags
- Exclusion: Active fever >38.5°C, uncontrolled seizure within 24 hours, or acute metabolic crisis.
- Exclusion: Therapeutic anticoagulation (e.g., warfarin) without physician clearance for venipuncture.
- Exclusion: Known severe needle phobia with vasovagal syncope history — request medical escort.
- ER Red Flags post‑draw: severe pallor, shortness of breath, loss of consciousness, or bleeding that doesn’t stop with pressure.
Patient FAQ & Clinical Guidance
1. What does the MARS2 gene test detect and why is it ordered?
Direct Answer This NGS test detects pathogenic mutations in the MARS2 gene to confirm Combined Oxidative Phosphorylation Deficiency Type 25, a rare metabolic disorder. It is ordered when clinical symptoms like lactic acidosis, hypotonia, and multisystem involvement suggest a mitochondrial disease, or when a family history warrants carrier screening. The test sequences the entire coding region, enabling precise genetic counselling and family risk assessment.
2. How is the sample collected and what is the turnaround time?
Direct Answer A blood sample (whole blood, FTA card, or extracted DNA) is collected via VIP home phlebotomy between 8 AM and 11 PM; results are delivered in 3 to 4 weeks. Our DHA‑licensed phlebotomists follow ISO cold‑chain protocols to maintain DNA integrity. The pre‑test genetic counselling session (pedigree chart required) ensures the sample submission meets laboratory acceptance criteria.
3. Is this test covered by UAE insurance and what do I need for reimbursement?
Direct Answer Most UAE insurers cover genetic testing when a physician referral, detailed clinical notes, and the pre‑ counselling report are provided; we verify your coverage via WhatsApp. Send your insurance card and referral to +971 54 548 8731 before the draw. Our billing team will handle pre‑authorisation requests and direct billing to all major networks, minimising your out‑of‑pocket expense.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
All genetic testing services at DNA Labs UAE operate under DHA Facility License Number 1143. We adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is encrypted, stored on UAE-based servers, and never shared with third parties without explicit consent. Clinical safety and patient consent practices follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MARS2 Gene Combined Oxidative Phosphorylation Deficiency Type 25 (COXPD25) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (average 18 working days) |
| Sample Type / Matrix | Whole blood (EDTA or FTA card), or extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina platform, ISO 9001:2015 accredited |
| ICD-10-CM Code | E88.4 (Mitochondrial metabolism disorders) |
| LOINC Code | 82304-5 (Genetic analysis of mitochondrial genome) |
| DHA Facility License & Laboratory Address | License No: 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab Branding: DNA Labs UAE |
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