Test Price
2,800 AED✅ Home Collection Available
LZTR1 Gene Noonan Syndrome Type 10 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 certified NGS processing (Cert: INT/EGQ/2509DA/3139). Full LZTR1 gene coverage with copy number variant detection.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM for whole blood, extracted DNA, or FTA card.
- Clinical Guidance: Complimentary 15‑minute post‑test teleconsultation with a DHA‑licensed genetic counselor to interpret results and plan next steps.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. Pre‑authorization and claim submission handled.
Test Overview & Methodology
The LZTR1 Gene NGS Test detects pathogenic variants in the LZTR1 gene associated with Noonan syndrome type 10, a multisystem disorder marked by dysmorphic features, congenital heart defects, and increased cancer risk. The assay uses next‑generation sequencing to achieve 99.9% sensitivity for single‑nucleotide variants, small indels, and copy number changes across all exons, intron‑exon boundaries, and regulatory regions.
| Feature | Our LZTR1 NGS Test | Conventional Sanger Sequencing |
|---|---|---|
| Coverage | Full gene (all exons, intron‑exon boundaries, regulatory regions) | Coding exons only; may miss deep intronic or regulatory mutations |
| Sensitivity | 99.9% for single‑nucleotide variants, small indels, and copy number changes | ~95% for point mutations; poor detection of large deletions/duplications |
| Turnaround Time | 3 – 4 Weeks | 6 – 8 Weeks |
| Cost (AED) | 2,800 | 3,500 |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I emphasize that an LZTR1 test result is a powerful diagnostic piece, but it must always be interpreted in conjunction with the full clinical picture and family history. A negative result does not exclude Noonan syndrome if the phenotype is strong; whole‑exome sequencing should then be considered. Never alter a treatment plan based solely on genetic findings — always consult your managing physician.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory: Medication Continuation
⚠ Warning: Do not discontinue any prescribed medication without consulting your doctor. Genetic test findings do not replace clinical judgment and are not intended to alter ongoing therapy without physician guidance.
Clinical Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Inability to provide a blood sample due to severe hemodynamic instability; unresolved bleeding diathesis requires prior physician clearance. This test is not validated for standalone prenatal diagnosis without invasive sampling and specialized genetic counseling.
- Emergency Red Flags — Seek Immediate Medical Care: If the individual develops new‑onset seizures, severe respiratory distress, signs of acute leukemia (unexplained paleness, petechiae, fever), or sudden deterioration in cardiac status, proceed to the nearest Emergency Department irrespective of pending test results.
Patient FAQ & Clinical Guidance
1. What is the LZTR1 gene test for Noonan syndrome type 10?
This NGS test detects LZTR1 gene mutations causing Noonan syndrome type 10 with 99.9% accuracy for diagnosis. The assay sequences the entire LZTR1 gene to identify pathogenic variants underlying dysmorphic features, congenital heart defects, short stature, and elevated cancer predisposition. Results guide targeted surveillance and family variant testing.
2. How is the sample collected and what is the turnaround time?
Our DHA‑licensed phlebotomists perform a painless venipuncture or finger‑prick for the FTA card during scheduled home visits (8 AM – 11 PM). Samples are transported under strict cold‑chain conditions to our ISO‑certified laboratory. The digital report is delivered within 3 to 4 weeks.
3. Does this test require genetic counseling?
Yes, pre‑test and post‑test genetic counseling is mandatory under UAE law for all genetic testing involving minors or hereditary conditions. A certified genetic counselor explains the scope, possible outcomes, and family implications before the blood draw, and another session ensures full understanding of results and recommended actions.
UAE Regulatory & Data Privacy Adherence
This test and all associated data handling comply with the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is stored with bank‑level encryption and access is restricted to authorized clinical personnel.
Clinical & Logistical Metadata
| Test Name | LZTR1 Gene NGS Test for Noonan Syndrome Type 10 |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card (VIP Mobile Phlebotomy Home Collection available) |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage and CNV detection |
| ICD-10-CM Code | Q87.1 |
| LOINC Code | 92655-1 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians