Test Price
2,800 AED✅ Home Collection Available
LARP7 Gene Alazami Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LARP7 gene encodes a chaperone that stabilizes non‑coding RNAs; biallelic loss‑of‑function mutations cause Alazami syndrome, a rare primordial dwarfism disorder with microcephaly, severe growth retardation, and characteristic facial dysmorphism. This Next‑Generation Sequencing (NGS) test screens all coding exons and exon‑intron boundaries with high coverage, delivering >99.9% analytical sensitivity for point mutations and small indels.
| Feature | Our LARP7 NGS Test | Closest Alternative (Single‑Gene or WES) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) with ≥100x mean depth, full gene coverage | Sanger sequencing (one exon at a time) or whole‑exome sequencing (broader, high VUS rate) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks (Sanger/WES) |
| Diagnostic Yield | >99.9% for pathogenic variants in LARP7 | ~95% (Sanger) / incidental findings common (WES) |
| Accreditation | ISO 9001:2015, DHA‑licensed facility (#1143) | Varies by provider |
| All‑inclusive Price | 2800 AED | 3500–5000 AED |
Physician Insight & Safety Protocols
“A meticulous clinical correlation is essential when interpreting LARP7 results. A positive finding provides molecular confirmation for Alazami syndrome, but a negative result does not exclude atypical presentations or deep intronic variants. Always integrate the family history and dysmorphology evaluation.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Medication Advisory
⚠️ Medication Advisory: Do not discontinue any prescribed medication without consulting your treating physician. Genetic testing does not replace ongoing clinical management.
Exclusion Criteria & ER Red Flags
- Severe anemia (Hb <7 g/dL) or active bleeding disorder – clarify with your doctor before blood collection.
- Acute febrile illness or systemic infection – reschedule until fully recovered.
- If you have a known allergy to antiseptics used in phlebotomy, inform the collection team.
- 🚨 Seek immediate emergency care if, after sample collection, you experience:
- Sudden fainting, severe dizziness, or uncontrolled bleeding from the puncture site.
- Rapidly spreading redness, warmth, or pus at the site (may indicate infection).
- Any unexpected sharp pain, shortness of breath, or chest tightness.
Patient FAQ & Clinical Guidance
1. What is the LARP7 gene and Alazami syndrome?
Snippet: Alazami syndrome is a rare autosomal recessive disorder caused by mutations in the LARP7 gene, resulting in primordial dwarfism, microcephaly, and distinct facial features.
The LARP7 protein is crucial for RNA stability; loss of function disrupts early development, leading to severe growth failure, intellectual disability, and skeletal anomalies. This test confirms the diagnosis at the molecular level, allowing for precise genetic counseling and management tailored to the child’s needs.
2. Who should consider this LARP7 gene test?
Snippet: Infants and children presenting with microcephaly, severe short stature, dysmorphic facies, and developmental delay should undergo LARP7 sequencing after a dysmorphology evaluation.
Adults with a clinical suspicion of a forme fruste or a family history suggestive of Alazami syndrome may also benefit. A genetic counseling session is mandatory prior to testing to review the pedigree and obtain informed consent.
3. How accurate is this NGS for Alazami syndrome?
Snippet: Our NGS assay detects over 99.9% of pathogenic single‑nucleotide variants and small insertions/deletions in the LARP7 gene, with validation confirmed under ISO 9001:2015 standards.
We amplify all coding exons using long‑range PCR, followed by deep sequencing and analysis by clinically certified bioinformatics pipelines. Results are interpreted following ACMG guidelines, and any clinically actionable findings are reported with clear recommendations.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
All genetic data is encrypted, access-controlled, and processed solely for the intended diagnostic purpose. Informed consent is obtained prior to testing, and results are shared only with the ordering physician and the patient.
Clinical & Logistical Metadata
| Test Name | LARP7 Gene Alazami Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene coverage, ≥100x mean depth |
| ICD-10-CM Code | Q87.1 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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