Test Price
2,800 AED✅ Home Collection Available
LAMB3 Gene Sequencing for Junctional Epidermolysis Bullosa, Non‑Herlitz Type (NGS) in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post‑Test Clinical Guidance for Result Interpretation by a Genetic Counsellor.
- Insurance: Direct Billing Verification and Pre‑authorisation via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LAMB3 Gene Sequencing test uses next‑generation sequencing (NGS) to detect pathogenic variants in the LAMB3 gene, confirming the diagnosis of junctional epidermolysis bullosa non‑Herlitz type with 99.9% sensitivity. The analysis covers the full coding region and splice sites.
| Feature | Our Test (NGS LAMB3 Full Gene) | Closest Alternative (Sanger Selected Exons) |
|---|---|---|
| Precision | Full coding region + splice sites, >99.9% analytic sensitivity | Limited to a few hot‑spot exons, ~85‑90% sensitivity |
| Methodology | Next‑Generation Sequencing (Illumina platform, 100x mean coverage) | Sanger sequencing, lower throughput |
| Turnaround Time | 3‑4 Weeks (21‑28 days) | 4‑6 Weeks |
Physician Insight & Safety Protocols
“LAMB3 gene sequencing is the gold standard for confirming junctional epidermolysis bullosa non‑Herlitz type. This comprehensive NGS analysis covers the entire coding region and splice sites with >99.9% sensitivity. I advise that all results be discussed with a genetic counselor and dermatologist for appropriate clinical management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Consultation Advisory
Do not alter any prescribed treatments based solely on genetic test results. Genetic findings are one component of a comprehensive diagnostic workup. Always consult your treating physician before making any changes to medication or therapy.
Safety Exclusion Criteria & Red Flags
- Exclusion Criteria: Active cutaneous infection at the venipuncture site; inability to provide informed consent; minors without a legal guardian present.
- Red Flag Symptoms (seek emergency care immediately): Widespread blistering with signs of secondary bacterial infection, severe feeding difficulty in infants, respiratory distress, or any systemic inflammatory response syndrome (SIRS) criteria.
Patient FAQ & Clinical Guidance
1. What does the LAMB3 gene test detect, and who should consider it?
This test detects pathogenic variants in the LAMB3 gene to confirm junctional epidermolysis bullosa non‑Herlitz type with over 99% diagnostic sensitivity. It is recommended for patients presenting with skin fragility, erosions, and nail dystrophy suggestive of junctional EB, especially when immunofluorescence mapping indicates laminin‑332 deficiency.
2. How is the sample collected for this DNA test?
A simple blood draw or buccal swab is collected by our DHA‑licensed phlebotomist at home using strict cold‑chain protocol. The sample can be whole blood, extracted DNA, or a blood spot on an FTA card, ensuring maximum convenience and stability during transport.
3. How long do results take, and what should I do after receiving them?
Results are reported within 3 to 4 weeks and include a complimentary 20‑minute genetic counselling session. After receiving the report, book a consultation with your dermatologist or geneticist to discuss clinical implications and necessary follow‑up, including family screening if indicated.
UAE Regulatory & Data Privacy Adherence
All genetic testing at DNA Labs UAE is performed in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our DHA‑licensed facility (License #1143) ensures the highest standards of data security and patient confidentiality.
Clinical & Logistical Metadata
| Test Name | LAMB3 Gene Sequencing for Junctional Epidermolysis Bullosa, Non‑Herlitz Type (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21‑28 days (3‑4 weeks) |
| Sample Type / Matrix | Whole Blood or Buccal Swab |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform, 100x mean coverage |
| ICD‑10‑CM Code | Q81.1 |
| LOINC Code | 101427-8 |
| DHA Facility License & Address | License #1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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