Test Price
2,800 AED✅ Home Collection Available
HCN1 Gene (Early Infantile Epileptic Encephalopathy Type 24) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين HCN1 (التهاب الدماغ الصرعي الطفلي المبكر من النوع 24) بتقنية تسلسل الجيل التالي (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited Processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Clinical Test Overview
The HCN1 gene test detects pathogenic variants associated with Early Infantile Epileptic Encephalopathy Type 24 (EIEE24), a severe neurodevelopmental disorder. Using next‑generation sequencing, this analysis supports accurate diagnosis, prognosis, and genetic counselling. يكشف تحليل جين HCN1 الطفرات المسببة لاعتلال الدماغ الصرعي الطفلي المبكر، مما يتيح تشخيصًا دقيقًا واستشارة وراثية موجَّهة.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | High‑depth NGS with Sanger validation | Targeted mutation panel (limited variants) |
| Methodology | Next‑Generation Sequencing (NGS) | Sanger sequencing of select exons |
| Turnaround | 3 – 4 Weeks | 5 – 8 Weeks |
Physician Insight & Safety Protocol
“Genetic findings must be interpreted within the full clinical context. A positive HCN1 result confirms the molecular basis of your child’s epilepsy, but treatment decisions require correlation with EEG, neuroimaging, and expert neurological assessment. We stand with your family at every step of the diagnostic journey.”
— Dr. Prabhakar Reddy, Consultant Neurologist, DHA License 61713011
⚠️ Medication Warning: Do not discontinue prescribed anti‑epileptic drugs or alter dosage without consulting your treating physician. Genetic results are not a substitute for clinical management.
🧪 Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (patient or legal guardian). Inadequate sample volume or degraded DNA.
- Exclusion: Minors without parental/guardian written consent as per UAE CDS Law 2026.
- Red Flag: New‑onset seizure clusters or status epilepticus — seek immediate emergency care.
- Red Flag: Progressive loss of developmental milestones or respiratory irregularities during seizures — urgent neurological evaluation required.
Pre‑Test Information
A detailed clinical history and a genetic counselling session (pedigree charting) are required before sample collection. The consultation ensures all family members potentially affected by HCN1‑related encephalopathy are identified.
Patient FAQ & Clinical Guidance
1. How does this genetic test change my child’s treatment plan? كيف يغير هذا الاختبار الجيني خطة علاج طفلي؟
This identifies the exact HCN1 mutation, allowing your neurologist to tailor anti‑seizure medications and anticipate developmental outcomes. It supports precision therapy selection and avoids trial‑and‑error prescribing. يحدد الاختبار الطفرة الدقيقة في جين HCN1، مما يمكّن طبيب الأعصاب من تخصيص أدوية الصرع والتنبؤ بالتطور الحركي للطفل.
2. What sample types are accepted, and how is collection performed? ما أنواع العينات المقبولة وكيف يتم سحبها؟
We accept whole blood, extracted DNA, or a dried blood spot on an FTA card; a certified phlebotomist visits your home. The sample is transported under cold‑chain conditions directly to our ISO‑accredited laboratory. نقبل الدم الكامل، الحمض النووي المستخلص، أو بقعة دم جافة على بطاقة FTA، ويقوم فني معتمد بزيارة منزلك لسحب العينة.
3. Why is NGS technology preferred for EIEE24 diagnosis over older methods? لماذا تقنية NGS مفضلة لتشخيص EIEE24 مقارنة بالطرق القديمة؟
NGS simultaneously reads all coding regions of HCN1, detecting rare variants that older single‑exon tests miss completely. With orthogonal confirmation, false‑positive rates are negligible. تقرأ تقنية NGS جميع مناطق الجين دفعة واحدة، وتكشف طفرات نادرة قد تفوتها الاختبارات التقليدية.
☑ This service is compliant with Federal Decree‑Law No. 41 of 2024 (Art. 87) and UAE PDPL. All genetic testing of minors adheres to CDS Law 2026.
☑ ISO 9001:2015 Certified Laboratory, Cert. No.: INT/EGQ/2509DA/3139. DHA Facility License: 9834453.
☑ ICD‑10‑CM codes in use: G40.822 (Epileptic encephalopathy), Z15.89 (Genetic susceptibility to other disease), Z13.858 (Encounter for screening for other nervous system disorders).
☑ LOINC: 82887‑0 (https://loinc.org/82887-0/)
☑ 24/7 WhatsApp Support: +971 54 548 8731
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