Test Price
2,800 AED✅ Home Collection Available
HCN1 Gene (Early Infantile Epileptic Encephalopathy Type 24) Genetic Test in UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited Processing for HCN1 gene variant detection.
Premium Logistics: VIP Mobile Phlebotomy with Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
Clinical Guidance: Complimentary post-test telephonic consultation with a Consultant Medical Genetics specialist to review your child's results.
Insurance & Billing: Direct billing verification and appointment scheduling via WhatsApp +971 54 548 8731.
Price: 2,800 AED — includes full gene sequencing, Sanger validation, and a detailed clinical report.
Test Overview & Methodology
The HCN1 gene test uses next-generation sequencing (NGS) to detect pathogenic and likely pathogenic variants associated with Early Infantile Epileptic Encephalopathy Type 24 (EIEE24). This severe neurodevelopmental disorder presents with early-onset seizures, developmental delay, and intellectual disability. Our analysis covers all coding exons and splice-site regions of HCN1, with orthogonal confirmation via Sanger sequencing to ensure 99.9% diagnostic sensitivity.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | High-depth NGS with Sanger validation for all coding regions | Targeted mutation panel covering limited known variants |
| Methodology | Next-Generation Sequencing (NGS) plus Sanger confirmation | Sanger sequencing of selected exons only |
| Turnaround Time | 3 – 4 Weeks | 5 – 8 Weeks |
Physician Insight & Safety Protocols
“Identifying a pathogenic HCN1 variant provides a definitive molecular diagnosis for your child’s epileptic encephalopathy, yet therapeutic decisions must always integrate EEG patterns, neuroimaging findings, and a comprehensive neurological assessment. Our role is to deliver accurate genomic data so your care team can tailor management with confidence.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Medication Advisory
⚠️ Do Not Alter Prescribed Therapy
Do not discontinue, adjust, or add any anti-epileptic drugs without direct supervision by the treating neurologist. Genetic test results complement — but do not replace — ongoing clinical management. Abrupt medication changes can precipitate seizure worsening or status epilepticus.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent by the patient or legal guardian. Insufficient sample volume or degraded DNA that fails quality control metrics.
- Exclusion: Minors without written parental or guardian consent as required by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Red Flag: New-onset seizure clusters or any episode of status epilepticus — seek immediate emergency medical care.
- Red Flag: Progressive loss of developmental milestones, respiratory irregularities during seizures, or altered consciousness — urgent neurological evaluation is required.
Patient FAQ & Clinical Guidance
1. How will the HCN1 genetic test change my child’s treatment plan?
Identifying the exact HCN1 mutation enables your neurologist to select targeted anti-seizure medications, anticipate developmental trajectory, and provide accurate recurrence risk counselling for the family. This precision approach reduces trial-and-error prescribing and supports personalized care.
2. What sample types are accepted and how is collection performed?
We accept whole blood (EDTA tube), extracted DNA (minimum 1 µg), or a dried blood spot on an FTA card. Our VIP Mobile Phlebotomy service sends a certified phlebotomist to your home between 8 AM and 11 PM daily. The specimen is transported under temperature-controlled cold-chain conditions directly to our ISO-accredited laboratory.
3. Why is next-generation sequencing preferred over older methods for EIEE24?
NGS simultaneously sequences all coding exons and flanking splice regions of HCN1 in a single assay, detecting novel and rare variants that single-exon Sanger testing would miss. Combined with orthogonal confirmation, this approach delivers extremely low false-positive and false-negative rates.
4. What pre-test information is required before sample collection?
A detailed clinical history and a formal genetic counselling session with pedigree charting are mandatory. This consultation identifies at-risk family members, discusses inheritance patterns, and ensures informed consent is obtained according to UAE federal regulations.
5. How long does it take to receive results and how will they be delivered?
Turnaround time is 3 to 4 weeks from sample receipt. Results are delivered via a secure digital portal and a printed clinical report signed by the reporting geneticist. A telephonic consultation with our Consultant Medical Genetics is included to explain the findings and answer your questions.
UAE Regulatory & Data Privacy Adherence
- Data Protection: All genetic and personal data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Safety & Consent: Sample collection and genetic analysis follow the standards set forth in Federal Decree-Law No. 4 of 2016 on Medical Liability. Informed consent is obtained from every patient or legal guardian prior to testing.
- Laboratory Accreditation: ISO 9001:2015 Certified Laboratory, Cert. No.: INT/EGQ/2509DA/3139.
- Round-the-Clock Support: 24/7 WhatsApp assistance at +971 54 548 8731 for appointment booking, insurance verification, and result inquiries.
Clinical & Logistical Metadata
| Test Name | HCN1 Gene Full Sequencing — Early Infantile Epileptic Encephalopathy Type 24 (EIEE24) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA (≥1 µg), or dried blood spot on FTA card — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) of all coding exons and splice junctions with orthogonal Sanger confirmation. |
| ICD-10-CM Code | G40.822, Z15.89, Z13.858 |
| LOINC Code | 82887-0 (https://loinc.org/82887-0/) |
| DHA Facility License & Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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