Test Price
2,800 AED✅ Home Collection Available
GRIP1 Gene (Fraser Syndrome) Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic post-test clinical guidance by a DHA-licensed Consultant Medical Genetics for result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GRIP1 Gene (Fraser Syndrome) Genetic Test employs next-generation sequencing (NGS) to comprehensively analyze the coding region and splice sites of the GRIP1 gene. This targeted analysis detects pathogenic single nucleotide variants, small insertions and deletions, and copy number alterations associated with Fraser syndrome—a rare autosomal recessive disorder characterized by cryptophthalmos, syndactyly, and renal malformations. Confirmatory Sanger sequencing is applied to all reported variants to ensure analytical accuracy.
| Feature | Our Test (NGS) | Traditional Sanger Sequencing |
|---|---|---|
| Gene Coverage | Entire coding region & splice sites | Targeted exons only |
| Diagnostic Sensitivity | 99.9% (ISO 9001:2015 validated) | ~95% |
| Turnaround | 3 to 4 weeks | 6 to 8 weeks |
| Price (AED) | 2,800 AED | 4,500+ AED |
Physician Insight & Safety Protocols
Insight from Consultant Medical Genetics
“Accurate molecular diagnosis of Fraser syndrome requires complete GRIP1 gene interrogation combined with detailed pedigree analysis and clinical phenotyping. Our NGS platform provides the depth necessary to detect cryptic splice variants and mosaic alterations that Sanger sequencing may miss. Post-test genetic counseling is essential for translating genomic findings into actionable family planning and surveillance strategies.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice
Medication & Clinical Precautions
Do not discontinue, adjust, or initiate any prescribed medication or therapy based solely on genetic test results without consulting your referring physician or a qualified medical geneticist. This test provides diagnostic information and should be used in conjunction with full clinical evaluation and family history assessment.
Exclusion Criteria & Emergency Red Flags
- Inadequate sample quality (insufficient DNA, hemolysis, or contamination) will necessitate recollection to maintain diagnostic accuracy.
- Individuals who have received a bone marrow transplant within the past 6 months should not undergo this test due to the risk of donor DNA interference.
- If you or your child experiences acute respiratory distress, seizures, or severe abdominal pain, seek emergency medical care immediately—do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What is the GRIP1 Gene (Fraser Syndrome) Genetic Test?
This targeted NGS test sequences the entire coding region and intron-exon boundaries of the GRIP1 gene to detect disease-causing variants associated with Fraser syndrome. The analysis identifies single nucleotide variants, small insertions and deletions, and copy number changes, providing a definitive molecular diagnosis that informs clinical management, surveillance, and family counseling.
2. How much does the test cost and what is the turnaround time?
The GRIP1 NGS test is priced at 2,800 AED. Results are reported within 3 to 4 weeks from sample receipt. The cost includes DNA extraction, library preparation, sequencing, bioinformatics analysis, variant interpretation, and a clinical report signed by the Consultant Medical Genetics. Home collection fees are separate and may be covered by insurance.
3. How do I prepare for the GRIP1 genetic test?
Attend a mandatory pre-test genetic counseling session for pedigree charting and informed consent. Provide a detailed three-generation family history focusing on congenital anomalies, stillbirths, and known genetic conditions. No fasting is required. Inform the phlebotomist if you are taking anticoagulant therapy. A peripheral whole blood sample (5 mL in EDTA) is collected.
4. Who should consider this genetic test?
This test is indicated for individuals with clinical features suggestive of Fraser syndrome including cryptophthalmos, syndactyly, renal agenesis or dysplasia, and ambiguous genitalia. It is also appropriate for couples with a family history of Fraser syndrome who are planning pregnancy, and for fetuses with ultrasound findings consistent with the disorder.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
This genetic test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures align with Federal Decree-Law No. 4 of 2016 on Medical Liability regarding patient safety, informed consent, and clinical governance. Our facility operates under DHA Facility License No. 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). Genetic data is stored on encrypted servers, access is role-based, and no information is disclosed without explicit written consent.
Clinical & Logistical Metadata
| Test Name | GRIP1 Gene (Fraser Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) |
| Methodology Used | Next-Generation Sequencing (NGS) with confirmatory Sanger sequencing |
| ICD-10-CM Code | Q87.0 (Fraser syndrome) |
| LOINC Code | 21634-2 (Genetic analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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