Test Price
2,800 AED✅ Home Collection Available
GJB2 Gene (Knuckle Pads, Leukonychia, Sensorineural Hearing Loss) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
Gold‑standard NGS sequencing of the entire GJB2 gene with 99.9% analytical sensitivity, ISO‑certified cold‑chain home collection, and telephonic post‑test clinical guidance. All procedures comply with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Insurance verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced test uses Next‑Generation Sequencing (NGS) to detect single nucleotide variants, small indels, and copy number changes across the entire GJB2 gene. It is the definitive genetic assay for hereditary sensorineural hearing loss accompanied by knuckle pads and leukonychia, providing unequivocal carrier status and prognostic information.
| Feature | Our Test – GJB2 NGS | Conventional Sanger Sequencing |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) with CNV detection | Sanger sequencing (limited to predefined hotspots) |
| Analytical Sensitivity | 99.9% – covers entire coding region ±10 bp splice sites | ~85‑90% (misses rare or novel variants) |
| Turnaround Time | 3‑4 weeks | 4‑6 weeks |
| Price | AED 2,800 | ~AED 3,500 |
| Regulatory Compliance | DHA Licensed, ISO 9001:2015, UAE PDPL | Variable |
Physician Insight & Safety Protocols
“Every genetic variant must be interpreted within the full clinical picture. This test is a powerful tool, but it should never replace a thorough audiological and dermatological evaluation. I advise all patients to attend a dedicated genetic counselling session prior to sampling to understand the implications, especially when planning a family or managing a child’s hearing loss.” – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
⚠ Important Notice
Do not discontinue any prescribed medication — including hearing aids, cochlear implant support therapies, or topical keratolytic agents — without consulting your treating physician. This test does not alter ongoing treatment plans.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria & Emergency Red Flags
- Genetic testing for minors must be accompanied by explicit written consent from a legal guardian (UAE Child Protection Law).
- Not indicated as a standalone emergency diagnostic — always correlate with clinical and audiometric findings.
- Seek immediate emergency care if you experience sudden severe hearing loss, acute ear pain, high fever with skin blistering, or signs of meningitis.
- Patients on anticoagulation therapy should inform the phlebotomist before sample collection.
Patient FAQ & Clinical Guidance
1. What is the GJB2 gene test and who should consider it?
The GJB2 NGS test identifies pathogenic mutations in the GJB2 gene that cause autosomal dominant/recessive sensorineural deafness often associated with knuckle pads and leukonychia; it is recommended for individuals with congenital hearing loss, positive family history, or syndromic skin findings.
2. How accurate is this NGS and what is the turnaround time?
With 99.9% analytical sensitivity for point mutations and copy number variants across the entire GJB2 gene, this NGS assay delivers definitive results within 3 to 4 weeks through our ISO‑certified laboratory.
3. Is home sample collection available in the UAE and does insurance cover the cost?
Yes, we provide DHA‑licensed hospital‑grade home phlebotomy from 8 AM to 11 PM with cold‑chain transport; insurance billing is verified directly via WhatsApp at +971 54 548 8731 prior to your appointment.
UAE Regulatory & Data Privacy Adherence
This test is performed under the framework of Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted and processed in compliance with UAE health data protection standards.
Clinical & Logistical Metadata
| Test Name | GJB2 Gene (Knuckle Pads, Leukonychia, Sensorineural Hearing Loss) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood |
| Methodology Used | Next‑Generation Sequencing (NGS) with CNV detection |
| ICD-10-CM Code | H90.5, Q87.8 |
| LOINC Code | 49929-6 |
| DHA Facility License & Laboratory Address | License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians