Also known as: LAMM Syndrome Genetic Test, Labyrinthine Aplasia, Microtia, Microdontia Genetic Test
Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 Weeks
FGF3 Gene Congenital Deafness with Inner Ear Agenesis, Microtia, and Microdontia Genetic Test in UAE
Executive Summary & Core Metrics
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test examines the entire coding region of the FGF3 gene for pathogenic variants linked to a rare syndrome encompassing congenital deafness, complete inner ear agenesis (Michel aplasia), microtia, and microdontia. The condition is often referred to as LAMM syndrome (Labyrinthine Aplasia, Microtia, Microdontia).
The test employs high-depth sequencing on the Illumina NovaSeq platform followed by Sanger confirmation of all reported variants, ensuring maximum analytical sensitivity and specificity for definitive molecular diagnosis.
| Feature | Our Test (NGS + Sanger Confirmation) | Closest Alternative (Targeted FGF3 Panel) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity | ~95%, limited to known hot spots |
| Methodology | Illumina NovaSeq with Sanger validation | qPCR/MLPA only; no full gene sequencing |
| Turnaround Time | 3โ4 weeks | 6โ8 weeks (outsourced) |
Physician Insight & Safety Protocols
โAs a DHA-licensed Consultant Medical Genetics, I emphasize that FGF3 gene sequencing results must be correlated with comprehensive audiologic, otologic, and dental phenotyping. This molecular test provides definitive confirmation of LAMM syndrome, but it does not substitute for multidisciplinary clinical evaluation including imaging of the temporal bone and assessment of renal function. All patients should receive pre-test and post-test genetic counselling.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice on Clinical Management
Important Clinical Advisory
Genetic test results provide diagnostic clarification but do not replace ongoing symptomatic care. Patients should continue all prescribed hearing amplification, speech therapy, and dental interventions as directed by their treating specialists. Any adjustments to management plans must only be made following consultation with the managing clinician.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria & ER Red Flags
- Exclusion: Non-consenting minors require guardian approval per Federal Decree-Law No. 4 of 2016 on Medical Liability; individuals unable to attend genetic counselling.
- Exclusion: Sample contamination or insufficient DNA quantity re-collection at no extra cost.
- Emergency Red Flags: Sudden progression of hearing loss, acute vertigo, or signs of meningitis. Seek immediate ENT emergency care.
Patient FAQ & Clinical Guidance
1. What does this DNA test detect?
1. What does this DNA test detect?
This NGS test comprehensively analyzes the FGF3 gene for pathogenic single nucleotide variants and small insertions/deletions that cause congenital deafness with inner ear agenesis, microtia, and microdontia LAMM syndrome. The test covers all coding exons and flanking intronic regions to identify both common and novel mutations.
2. How accurate is the test, and why does it take 3โ4 weeks?
2. How accurate is the test, and why does it take 3โ4 weeks?
Our test delivers 99.9% diagnostic sensitivity due to dual-platform validation: high-depth NGS followed by Sanger sequencing of all reported variants. The 3โ4 week turnaround allows rigorous bioinformatics analysis, variant interpretation, and clinical confirmation by our Consultant Medical Genetics.
3. What sample is needed, and can I collect it at home?
3. What sample is needed, and can I collect it at home?
A simple blood draw 3โ5 mL in EDTA tube or a single blood drop on an FTA card is sufficient. Our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service collects samples at home daily from 8 AMโ11 PM, maintaining cold-chain ISO compliance for specimen integrity.
4. Will insurance cover this genetic test?
4. Will insurance cover this genetic test?
We offer direct billing verification with major UAE insurers. Please send a photo of your insurance card to our WhatsApp line +971 54 548 8731 for a pre-test coverage assessment. Out-of-pocket pricing is also available at 2,800 AED.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This diagnostic service operates under DHA Facility License Number 1143 and adheres to all applicable UAE federal laws governing genetic testing and patient data. All genetic information is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection PDPL and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical consent and safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains ISO 9001:2015 certification Cert: INT/EGQ/2509DA/3139 for quality management systems.
For inquiries or support, contact us via WhatsApp: +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | FGF3 Gene Congenital Deafness with Inner Ear Agenesis, Microtia, and Microdontia Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA tube or FTA card) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q16.5, H90.3 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
ุชููู ุนู ุงูุชุฎู ูู. ุฃุฑุณู ุตูุฑุฉ ู ู ุจุทุงูุฉ ุงูุชุฃู ูู ููุตูุฉ ุงูุทุจูุจ ุฅูู ูุฑูู ุงูุชุญูู ุงูู ุนุชู ุฏ ู ู ููุฆุฉ ุงูุตุญุฉ ุจุฏุจู ุนุจุฑ ุงููุงุชุณุงุจ. ุงุญุตู ุนูู ุชุญุฏูุซ ุงูุญุงูุฉ ูู ุฏูุงุฆู.
Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required", "No medication or diet restrictions"]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians