Test Price
2,800 AED✅ Home Collection Available
CTSC Gene (Papillon-Lefèvre Syndrome) Genetic Test (NGS) in UAE | AED 2,800 | DNA Labs UAE
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% diagnostic sensitivity achieved through ISO-certified laboratory workflows and validated bioinformatics analysis.
- Concierge Logistics: VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM.
- Post-Test Clinical Guidance: Telephonic consultation with a genetic specialist to interpret results and outline next steps.
- Insurance Facilitation: Direct coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test analyzes the entire coding region of the CTSC gene to detect pathogenic variants associated with Papillon-Lefèvre syndrome, a rare autosomal recessive disorder characterized by severe early-onset periodontitis and palmoplantar keratoderma. Comprehensive coverage includes all exons, splice sites, and flanking intronic regions to ensure maximal variant detection.
| Feature | CTSC NGS Test at DNA Labs UAE | Alternative Sanger Sequencing |
|---|---|---|
| Diagnostic Sensitivity | 99.9% with full gene coverage including regulatory regions | Targeted exon analysis only; may miss deep intronic or splice variants |
| Methodology | Next-Generation Sequencing with ISO-validated bioinformatics pipeline | Capillary electrophoresis; lower throughput and resolution |
| Turnaround Time | 3-4 Weeks | 4-6 Weeks |
Physician Insight & Safety Protocols
As a consultant in medical genetics, I emphasize that CTSC gene sequencing results must be interpreted within the full clinical context including dermatological examination, dental assessment, and family pedigree. This test provides definitive molecular confirmation of Papillon-Lefèvre syndrome and enables proactive management of periodontal and cutaneous complications. However, genetic testing should complement—not replace—a comprehensive specialist evaluation. I strongly recommend post-test genetic counseling to integrate findings into a personalized care strategy.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not alter or discontinue any prescribed treatment regimen without direct consultation with your managing physician. Genetic test outcomes do not independently warrant immediate therapeutic changes.
Patient Safety & Exclusion Criteria
- This test is not indicated for acute medical emergencies; urgent clinical care must take precedence.
- Individuals without a suggestive clinical phenotype or documented family history should first undergo genetic counseling.
- For minors, testing requires explicit parental or guardian consent accompanied by pre-test genetic counseling, in accordance with UAE regulations.
- Red Flags Requiring Immediate Medical Attention: Rapid progression of skin lesions, uncontrolled gingival bleeding, signs of systemic infection, or new neurological symptoms—seek emergency care without delay.
Patient FAQ & Clinical Guidance
1. What is the purpose of the CTSC gene genetic test?
This test identifies disease-causing variants in the CTSC gene that underlie Papillon-Lefèvre syndrome, enabling early diagnosis, informed genetic counseling, and timely multidisciplinary care involving dermatology, dentistry, and clinical genetics.
2. How should I prepare and what sample type is required?
A standard peripheral blood sample, a dried blood spot on an FTA card, or an extracted DNA specimen is accepted. No fasting, dietary restrictions, or medication adjustments are required unless specifically instructed by your referring physician.
3. What does a positive result mean for my health management?
A positive result confirms the genetic predisposition to Papillon-Lefèvre syndrome and supports lifelong surveillance by a multidisciplinary team including periodontists, dermatologists, and genetic specialists. Early intervention can significantly reduce morbidity from periodontal disease and skin keratoderma.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit patient consent.
Clinical Liability Framework
Clinical testing and patient safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring accountability and highest standards of care throughout the testing lifecycle.
Laboratory Certification: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). All molecular genetic analyses are performed in our DHA-licensed facility in Dubai Healthcare City.
Clinical & Logistical Metadata
| Test Name | CTSC Gene (Papillon-Lefèvre Syndrome) Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, FTA Card Dried Blood Spot, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 94045-2 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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