Test Price
2,800 AED✅ Home Collection Available
CLDN16 Gene Hypomagnesemia Type 3 Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity – ISO 15189:2022 Accredited Laboratory
Gold‑standard Next Generation Sequencing (NGS) with complete CLDN16 gene coverage. Our facility (DHA License 1143) meets the highest precision benchmarks, ensuring a definitive result for hereditary hypomagnesemia.
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection
Available daily from 8 AM to 11 PM across all Emirates. A certified phlebotomist collects whole blood, extracted DNA, or a single drop on an FTA card under strict cold‑chain transport protocols.
Post‑Test Genetic Counseling Included
A dedicated 15‑minute tele‑counseling session with a Consultant Medical Geneticist to interpret your report and guide family cascade screening.
Direct Insurance Billing Verification – WhatsApp
Send your insurance card to +971 54 548 8731 for an instant eligibility check. We handle the entire pre‑authorization process.
Test Overview & Methodology
This genetic test analyzes the CLDN16 gene for pathogenic mutations responsible for familial hypomagnesemia type 3 (OMIM #248250), a rare autosomal recessive renal magnesium‑wasting disorder. The CLDN16 gene encodes claudin‑16, a tight‑junction protein essential for paracellular magnesium reabsorption in the thick ascending limb of the loop of Henle. Loss‑of‑function variants lead to profound hypomagnesemia, hypocalciuria, and nephrocalcinosis. Early molecular diagnosis enables targeted magnesium supplementation, prevents seizure complications, and informs long‑term renal surveillance.
| Feature | DNA Labs UAE – CLDN16 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) – full gene, all exons plus splice sites | Sanger sequencing – typically limited to targeted hotspot regions |
| Diagnostic Sensitivity | 99.9% (captures SNVs, indels, CNVs) | Roughly 95% for point mutations; often misses large deletions or duplications |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Options | Whole Blood, Extracted DNA, or single drop on FTA Card | Usually requires whole blood or extracted DNA |
| Home Collection | Included – VIP mobile phlebotomy, 8 AM to 11 PM, all UAE | Frequently not available |
Physician Insight & Safety Protocols
“From a clinical genetics perspective, early confirmation of a CLDN16 variant transforms management for families grappling with unexplained childhood hypomagnesemia, seizures, or growth delay. This NGS‑based test provides the clarity needed to initiate targeted therapy and screen at‑risk siblings. I always remind my patients that genetic results must be interpreted alongside serum electrolytes and renal imaging for a complete clinical picture.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Laboratory Advisory
Medication Safety Notice
Do not alter or discontinue any prescribed magnesium supplementation, diuretic therapy, or anti‑epileptic medication without explicit guidance from your treating physician. Genetic test results provide diagnostic information and do not replace clinical judgment. Always correlate molecular findings with concurrent lab values (serum magnesium, urinary calcium, creatinine) and imaging studies.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals who cannot provide fully informed consent per UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability; minors without parental or guardian consent; patients in acute medical crisis requiring immediate stabilization—sample collection must be deferred until the individual is clinically stable.
- Emergency Red Flags: Sudden onset of paralysis, severe cardiac arrhythmia, tetany, or altered consciousness warrants immediate emergency intervention regardless of pending genetic test results.
Patient FAQ & Clinical Guidance
1. What is the CLDN16 gene and why is it tested?
The CLDN16 gene provides instructions for producing claudin‑16, a tight‑junction protein in the kidney that controls magnesium reabsorption. Pathogenic variants disrupt this process, leading to familial hypomagnesemia type 3—a rare inherited condition marked by severe magnesium depletion, excessive urinary calcium loss, and kidney calcification. Testing confirms the diagnosis, directs magnesium supplementation strategies, and enables cascade screening of first‑degree relatives.
2. How is the test performed and can a sample be collected at home?
A single peripheral whole blood draw, extracted DNA from a buccal swab, or a dried blood spot on an FTA card is sufficient for analysis. Our DHA‑licensed phlebotomy team provides VIP mobile home collection across all Emirates daily from 8 AM to 11 PM. Samples are transported under temperature‑controlled cold‑chain logistics to the DNA Labs UAE facility in Dubai Healthcare City. Schedule your appointment via WhatsApp at +971 54 548 8731; same‑day visits are frequently available.
3. What happens if I carry a pathogenic CLDN16 variant? Will my insurance cover the test and treatment?
If a pathogenic or likely pathogenic variant is identified, our Consultant Medical Geneticist will conduct a post‑test counseling session to explain inheritance risks, guide magnesium supplementation, and outline renal monitoring protocols. Most UAE health insurance plans cover medically necessary genetic testing; send your policy details to +971 54 548 8731 for a pre‑authorization verification before sample collection. Treatment costs for magnesium replacement and periodic nephrology follow‑up are typically covered under standard outpatient benefits.
UAE Regulatory & Data Privacy Adherence
Data Protection & Legal Compliance
All genetic data is processed and stored in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. Results are released exclusively to the ordering physician and the patient through a secure, encrypted portal. DNA Labs UAE does not share genetic information with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | CLDN16 Gene Hypomagnesemia Type 3 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) – full gene coverage |
| ICD-10-CM Code | E83.42, E83.40, E83.41, E83.49 |
| LOINC Code | 94838-1 |
| DHA Facility License & Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians