Test Price
2,800 AEDโ Home Collection Available
ANKH Gene Chondrocalcinosis Type 2 Genetic Test (NGS) โ 2,800 AED โ DNA Labs UAE, Dubai Healthcare City
Executive Summary & Core Metrics
Core Offer
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-certified next-generation sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection; available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test genetic counselling for result interpretation and personalised care planning.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ANKH Gene Chondrocalcinosis Type 2 Genetic Test is a clinical-grade, next-generation sequencing (NGS) assay that screens the entire coding region of the ANKH gene for pathogenic variants linked to familial calcium pyrophosphate deposition disease (CPPD) โ also known as chondrocalcinosis type 2. Performed on whole blood, extracted DNA, or a single drop of blood on an FTA card, this test delivers a definitive molecular diagnosis with a turnaround time of 3 to 4 weeks, enabling rheumatologists, clinical geneticists, and orthopaedic surgeons to implement targeted surveillance and early intervention.
| Feature | Our NGS Test (ANKH Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Detection Sensitivity | 99.9% โ all coding exons ยฑ10 bp intronic boundaries | ~95% โ targeted amplicons; may miss deep intronic/regulatory variants |
| Methodology | Next-Generation Sequencing (NGS) โ massive parallel sequencing, variant confirmation by orthogonal methods | Sanger sequencing โ single-amplicon, low-throughput |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Sample Flexibility | Whole Blood, Extracted DNA, or One Drop Blood on FTA Card | Whole Blood or DNA only; FTA card not validated |
Physician Insight & Safety Protocols
Clinical Note from Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): โGenetic testing for ANKH-related chondrocalcinosis type 2 provides a definitive molecular diagnosis that enables targeted family screening and early intervention. Our NGS platform delivers 99.9% sensitivity across all coding exons, ensuring that pathogenic variants are detected with the highest confidence. Pre- and post-test genetic counselling are integral to this process, helping patients understand their results and integrate them into a personalised rheumatology care plan.โ
Important Safety Advisory
Do not alter or discontinue any prescribed medication without consulting your treating physician. Changes to treatment regimens must be guided by clinical assessment. If you experience sudden, severe joint pain with fever, redness, or inability to move the joint, seek emergency rheumatologic evaluation as this may indicate acute pseudogout. Should neurological symptoms such as confusion or seizures develop during the testing period, contact your physician immediately.
Exclusion Criteria & Clinical Prerequisites
- Minors below 8 years of age require legal guardian consent and a dedicated paediatric genetic counselling session, as mandated by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Pre-test genetic counselling is mandatory; inability to provide a valid clinical history or three-generation pedigree chart will preclude testing.
Patient FAQ & Clinical Guidance
1. What is the ANKH gene NGS test and what conditions does it detect?
This NGS assay reads the entire coding sequence of the ANKH gene to identify single-nucleotide variants, insertions, deletions, and copy-number changes that cause CPPD crystal deposition in cartilage. A positive result confirms familial chondrocalcinosis type 2 and guides your rheumatologist in managing inflammation, preventing joint damage, and screening at-risk family members.
2. How should I prepare for collection and is home phlebotomy reliable for this test?
Preparation is minimal: complete a genetic counselling session and provide a detailed three-generation family pedigree chart before sample collection. Our VIP mobile phlebotomy service uses ISO-certified cold-chain transport that preserves DNA integrity from venipuncture to the laboratory, ensuring the same clinical accuracy as an in-clinic draw. No fasting is required; inform the phlebotomist of any blood-thinning medications.
3. Can insurance cover this genetic test and what support is provided after results?
Most UAE health insurance policies cover genetic testing when medically indicated. We perform direct billing verification via WhatsApp prior to sample collection to confirm eligibility. Once the report is issued (3โ4 weeks), you will receive a telephonic clinical guidance session with a genetic specialist who explains the findings in plain language, outlines next steps with your rheumatologist, and can arrange family screening if requested.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the UAEโs data protection and healthcare regulatory framework. All patient data is processed and stored under the provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is licensed by the Dubai Health Authority (DHA) and follows ISO-certified standards for quality and security.
Clinical & Logistical Metadata
| Test Name | ANKH Gene Chondrocalcinosis Type 2 Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | M11.2 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians