Test Price
2,800 AED✅ Home Collection Available
ALS2 Gene Spastic Paralysis, Infantile Onset Ascending NGS Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Laboratory Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM across UAE).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Interpretation by a DHA-Licensed Consultant Medical Geneticist.
- Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ALS2 gene NGS test identifies pathogenic variants responsible for infantile-onset ascending spastic paralysis, a severe hereditary neurological disorder. Our UAE-based laboratory delivers definitive molecular confirmation with a 3–4 week turnaround, empowering families and physicians with accurate, actionable results. Next-generation sequencing provides comprehensive coverage of all exons and intron boundaries, detecting single nucleotide variants, small insertions, and deletions with 99.9% sensitivity.
| Parameter | Our Test (NGS) | Alternative (Sanger Sequencing) |
|---|---|---|
| Target Region Coverage | Full gene (all exons, intron boundaries) | Limited to known hotspots only |
| Variant Detection Sensitivity | 99.9% | ~85% for single nucleotide variants |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Types Accepted | Blood, Dried Blood Spot, Extracted DNA | Blood only |
| Price (AED) | 2,800 | 1,800–2,200 (may require multiple tests) |
Physician Insight & Safety Protocols
“A definitive molecular diagnosis of ALS2-related spastic paralysis enables precise genetic counseling and early intervention planning. However, a negative NGS result does not rule out other hereditary spastic paraplegia syndromes; comprehensive clinical correlation and, if indicated, broader panel testing remain essential. Families should always discuss result implications with a qualified geneticist before making care decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory & Precautions
⚠️ Medication Safety Advisory
Do not discontinue, alter, or initiate any prescribed therapy for spasticity management — including baclofen, tizanidine, or botulinum toxin — without explicit consultation with the treating neurologist or paediatrician. Abrupt changes may precipitate withdrawal symptoms or worsen motor function.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Samples from individuals under 1 week of age — neonatal screening is not applicable for this test.
- Exclusion: Inability to provide informed consent or absence of a legal guardian for minor patients.
- Emergency Red Flag: Acute respiratory distress, aspiration pneumonia, or new-onset seizures — seek immediate emergency care.
- Emergency Red Flag: Rapidly progressive spasticity leading to joint contractures or loss of ambulation — urgent neurological evaluation required.
Patient FAQ & Clinical Guidance
1. What is the ALS2 gene test used for?
This NGS test provides definitive molecular confirmation of infantile-onset ascending spastic paralysis by detecting disease-causing mutations in the ALS2 gene. A positive result enables early intervention, accurate prognosis, and informed genetic counseling for at-risk family members. The test achieves 99.9% diagnostic sensitivity through comprehensive exon and intron boundary coverage.
2. How is the sample collected and what are the requirements?
A certified phlebotomist collects a venous blood sample at your home via our VIP Mobile Phlebotomy service, or you may submit a dried blood spot card or previously extracted DNA. A mandatory pre-test genetic counseling session is required to document family pedigree and confirm medical indication. Home collection is available daily from 8 AM to 11 PM across the UAE.
3. What is the turnaround time and how will I receive results?
Results are delivered within 3 to 4 weeks of sample receipt at our ISO 9001:2015-accredited laboratory. A DHA-licensed Consultant Medical Geneticist provides a complimentary telephonic interpretation to explain the findings, discuss clinical implications, and recommend next steps including reproductive counseling if appropriate.
4. Is genetic counseling recommended before and after the test?
Yes, pre-test genetic counseling is mandatory to ensure informed consent and to construct a three-generation family pedigree. Post-test counseling is strongly recommended for all patients, regardless of result, to discuss recurrence risks, carrier status implications for relatives, and available support resources within the UAE healthcare system.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework: This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Certification: ISO 9001:2015 Certified Laboratory (Cert: INT/EGQ/2509DA/3139). All genetic data is encrypted, access-restricted, and processed exclusively within UAE jurisdiction.
Patient Rights: You have the right to access, correct, and request deletion of your genetic data under PDPL. Data sharing with third parties requires explicit written consent except where mandated by UAE law.
Clinical & Logistical Metadata
| Test Name | ALS2 Gene Sequencing – Infantile Onset Ascending Spastic Paralysis NGS Panel |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Blood (Whole Blood EDTA), Dried Blood Spot (DBS), Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 81261-5 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
📞 WhatsApp Support & Booking: +971 54 548 8731
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