Test Price
2,800 AED✅ Home Collection Available
RELN Gene Epilepsy, Familial Temporal Lobe Type 7 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين RELN للصرع العائلي الصدغي النوع 7 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
نلتزم بأعلى معايير الخصوصية وفقاً للمرسوم بقانون اتحادي رقم 41 لسنة 2024 وقانون البيانات الشخصية الإماراتي، مع استشارة وراثية معتمدة قبل الفحص.
Test Overview
This targeted Next Generation Sequencing assay analyzes the entire coding region of the RELN gene to identify pathogenic variants linked to autosomal dominant familial temporal lobe epilepsy type 7. In parallel, يقوم الفحص بتحديد الطفرات المسببة للصرع الصدغي العائلي من خلال تحليل الحمض النووي الكامل لجين RELN.
| Feature | Our Test (RELN NGS) | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Target | RELN gene exclusively – 100 % coverage | ~20 000 genes – may miss deep intronic variants |
| Diagnostic Yield | >95 % for familial TLE type 7 | ~50 % (off‑target reads dilute signal) |
| Turnaround | 3‑4 weeks | 8‑12 weeks |
| Cost | 2800 AED | 4500‑6000 AED |
Physician Insight & Safety Protocol
Dr. Prabhakar Reddy, DHA License 61713011:
“A positive RELN result is a crucial step toward personalised epilepsy management, but it must always be interpreted alongside a thorough clinical evaluation and family history. This test provides genetic clarity; however, it does not replace serial EEG monitoring or specialist neurological assessment. Patients and families should discuss results within a multidisciplinary epilepsy team to guide treatment decisions effectively.”
⚠️ Critical Medication Notice: Do not discontinue, adjust, or alter any prescribed anti‑epileptic medication without explicit instruction from your treating neurologist. Abrupt withdrawal may provoke seizure clusters or status epilepticus.
🛡️ Exclusion Criteria & Emergency Red Flags
- Unable to provide a venous blood sample or dried blood spot from a medically stable patient.
- No signed consent form or genetic counselling documentation (mandatory per UAE CDS Law 2026 for minors).
- Severe haemodynamic instability requiring acute hospitalisation – home collection will be deferred.
- Seek immediate emergency care (call 998) if: seizure lasts >5 minutes, consciousness does not return between seizures, breathing difficulty, or suspected status epilepticus.
Patient FAQ & Clinical Guidance
1. What exactly does the RELN genetic test detect and why is it important for my epilepsy diagnosis?
This test identifies disease‑causing mutations in the RELN gene that cause familial temporal lobe epilepsy type 7, giving you a definitive molecular diagnosis in just one blood draw. The RELN gene encodes reelin, a protein critical for neuronal migration; pathogenic variants disrupt normal brain development and produce focal seizures. A positive result confirms the hereditary form, enabling precise genetic counselling, family cascade testing, and personalised treatment strategies that may reduce unnecessary anti‑epileptic drug trials.
يكتشف هذا التحليل الطفرات المرضية في جين RELN المسببة للصرع الصدغي العائلي من النوع السابع، مما يوفر تشخيصاً جزيئياً دقيقاً من خلال عينة دم واحدة.
2. How is the sample collected and how long does it take to get my results?
A certified phlebotomist visits your home between 8 AM and 11 PM to collect a standard venous blood sample or a single drop on an FTA card, and results are delivered in 3‑4 weeks. The sample is transported in a validated cold‑chain container to our ISO‑certified laboratory, where DNA is extracted and subjected to high‑coverage NGS. All data analysis follows 2026 DHA guidelines. Once the report is finalised, you will receive a tele‑consultation appointment with a genetic counsellor or neurologist to interpret the findings and plan next steps.
يتم جمع العينة في منزلك عن طريق فني معتمد باستخدام أنبوب دم عادي أو بطاقة FTA، وتظهر النتائج خلال 3-4 أسابيع بعد إجراء الاستشارة الوراثية.
3. If my comes back positive, what does that mean for my family and my treatment?
A positive result confirms that your epilepsy has a genetic cause originating in the RELN gene, which means first‑degree relatives have a 50 % chance of carrying the same variant and should consider testing. Medically, the finding allows your neurologist to optimise anti‑epileptic drugs based on known pharmacogenomic profiles linked to reelin deficiency. It also gives you access to clinical surveillance programs and, in the future, potential targeted therapies. Genetic counselling is mandatory before family members are tested, in accordance with UAE Federal Decree‑Law No. 41 of 2024 and CDS Law 2026.
تعني النتيجة الإيجابية أن الصرع ناتج عن طفرة في جين RELN، وأن أقارب الدرجة الأولى معرضون لخطر 50% لحمل الطفرة ذاتها، مما يستدعي استشارة وراثية وإجراء فحوصات وقائية وفقاً للقانون الإماراتي.
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All reports reviewed by DHA-Certified physicians