Test Price
2,800 AED✅ Home Collection Available
GRIN2B Gene Sequencing for Early Infantile Epileptic Encephalopathy Type 27 (Genetic Test) in UAE – 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS-based genetic test comprehensively analyses the entire GRIN2B gene to identify pathogenic variants responsible for Early Infantile Epileptic Encephalopathy Type 27 (EIEE27), a severe neurodevelopmental disorder characterized by early‑onset refractory seizures, profound intellectual disability, and movement abnormalities. The test aims to provide a precise genetic diagnosis, guiding anti‑epileptic therapy, family planning, and preparedness for future targeted treatments.
| Feature | Our GRIN2B NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Methodology | Targeted NGS full gene sequencing with Sanger confirmation; 100% coding exon coverage + intron‑exon boundaries | Whole exome capture and NGS; may miss deep intronic or regulatory GRIN2B variants |
| Turnaround Time | 3 – 4 Weeks | 6 – 8 Weeks |
| Diagnostic Yield for EIEE27 | >95% analytical sensitivity for GRIN2B variants | ~70% (broader but less focused) |
| Price | 2800 AED | 6000 – 8000 AED |
Physician Insight & Safety Protocols
“A confirmed GRIN2B pathogenic variant is a pivotal step toward personalized epilepsy management, but every genetic finding must be correlated with clinical semiology, video‑EEG data, and neurodevelopmental evaluation. A negative result does not rule out other genetic, metabolic, or structural causes; extended genomic testing may be indicated.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠ Medication Warning: Do not discontinue or adjust any anti‑epileptic drug without direct consultation with your treating physician. Abrupt withdrawal can provoke life‑threatening status epilepticus.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or acute medical instability requiring hospitalisation.
- Children under 2 months without continuous on‑site paediatric supervision.
- Inability to provide legally valid informed consent.
- Red Flag: Should the patient develop generalised convulsions, respiratory distress, or cyanosis during phlebotomy, immediately stop the procedure and activate emergency medical services.
Patient FAQ & Clinical Guidance
1. What does a positive GRIN2B test result mean?
A positive result confirms a pathogenic GRIN2B variant causing early infantile epileptic encephalopathy type 27, directly explaining your child's refractory seizures. This diagnosis ends the diagnostic odyssey and enables targeted therapy options, accurate genetic counselling for the family, and access to clinical trials. Paediatric neurologists can use this information to avoid unnecessary anti‑epileptic drugs and personalise seizure management.
2. How long does it take to receive the test result?
Standard turnaround time is 3 to 4 weeks, as meticulous NGS sequencing and variant interpretation follow international ACMG guidelines. The process includes DNA extraction, library preparation, high‑depth sequencing, bioinformatic filtering, and expert clinical review. Urgent samples can be prioritised with a pre‑authorised request; contact our laboratory support team for such cases.
3. Is genetic counselling included in the package?
Yes, a mandatory pre‑genetic counselling session to draw a detailed pedigree chart is included at no extra cost. This session ensures that family members at risk are identified and that you fully understand the inheritance pattern, potential reproductive options, and the implications of a positive or negative result. A summary report is shared with your referring physician.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with the UAE's Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed under stringent confidentiality protocols. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Your data remains secure and is never shared with third parties without explicit authorisation.
Clinical & Logistical Metadata
| Test Name | GRIN2B Gene Sequencing for Early Infantile Epileptic Encephalopathy Type 27 (Genetic Test) |
| Price (AED) | 2800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Targeted NGS Full Gene Sequencing with Sanger Confirmation |
| ICD-10-CM Code | G40.4 |
| LOINC Code | 10367-2 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians