Test Price
2,800 AED✅ Home Collection Available
CUX2 Gene-Related Early Infantile Epileptic Encephalopathy Type 67 (EIEE67) – Genetic Test in UAE
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity for CUX2 variant detection via ISO 9001:2015 accredited NGS, verified against current ACMG guidelines.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM for standard blood draws, plus secure courier for FTA cards.
- Clinical Guidance: Mandatory pre- and post-test genetic counselling through DHA-licensed specialists, with telephonic result interpretation in under 24 hours after report release.
- Insurance & Billing: Direct insurance verification via WhatsApp +971 54 548 8731 – we handle pre-authorisation and claim submission.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) genetic test screens the entire coding and splicing regions of the CUX2 gene to identify pathogenic variants causing early infantile epileptic encephalopathy type 67 (EIEE67), a severe neonatal-onset neurodevelopmental disorder characterised by refractory seizures. The test is performed on a peripheral whole blood sample, a dried blood spot (FTA card), or extracted DNA with a turnaround time of 3–4 weeks.
| Feature | Our Test – CUX2 EIEE67 NGS | Closest Alternative – Generic Epilepsy Panel |
|---|---|---|
| Methodology | Full CUX2 gene sequencing (promoter, exonic, and splice regions) via NGS with strict ACMG classification | Multi-gene panel covering >100 epilepsy genes; often lacks deep CUX2 coverage and regulatory regions |
| Turnaround Time | 3–4 weeks | 4–5 weeks |
| Genetic Counselling | Mandatory pre- and post-test sessions included | Often optional; additional cost |
| ISO Accreditation | ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | Variable; may not be local DHA-accredited |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I see the profound impact that early molecular diagnosis of EIEE67 can have on therapeutic decisions and family planning. This NGS test provides definitive variant identification critical for tailored antiepileptic management, prognosis estimation, and recurrence risk counselling. However, results must always be interpreted alongside clinical presentation, EEG patterns, and neuroimaging – no single test replaces a multidisciplinary neurological evaluation."
— Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠ Medication Advisory
Do not discontinue any prescribed antiepileptic or neurological medication without explicit instruction from your treating physician. Abrupt withdrawal can trigger severe seizure exacerbations. Please continue your regular schedule until your doctor reviews the test results and provides updated guidance.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (for minors, a legal guardian must sign); sample collection on FTA card must be performed by a DHA-licensed phlebotomist to ensure specimen integrity.
- Exclusion: This test is designed for postnatal diagnosis; it is not validated for prenatal or preimplantation genetic testing. Contact our genetics team for specialised options.
- Emergency Red Flag: If the patient experiences status epilepticus (a seizure lasting longer than 5 minutes or repeated seizures without regaining consciousness), profound respiratory distress, or a sudden severe regression in development, seek immediate emergency medical care—do not wait for test results.
- Sample Rejection: Haemolysed, clotted, or insufficient volume blood specimens will be rejected and require recollection.
Patient FAQ & Clinical Guidance
1. What does the CUX2 gene test for early infantile epileptic encephalopathy type 67 involve?
NGS-based CUX2 gene testing identifies pathogenic variants responsible for early infantile epileptic encephalopathy type 67. The test analyses your child's DNA (from blood or an FTA card) using Next-Generation Sequencing to detect even rare single-nucleotide changes and small deletions/duplications within the CUX2 gene. A DHA-certified genetic counsellor will discuss the implications before sample collection and after results are released, ensuring you fully understand the diagnostic outcome and any familial risks.
2. How should I prepare myself or my child for the CUX2 EIEE67 genetic test?
Continue all medications; provide comprehensive clinical history to your phlebotomist before the genetic blood draw. Unlike many blood tests, fasting is not required. You should bring a detailed list of all current medications (especially antiepileptics), any previous EEG reports, and a family history of seizures or neurological disorders. Our mobile team will review the pedigree chart with you if not already completed in a prior genetic counselling session; this data ensures accurate variant classification and personalised risk assessment.
3. When will I receive the results, and how are they interpreted?
CUX2 test results are ready in 3-4 weeks; secure portal delivery and mandatory genetic counselling follow. Once the NGS analysis is complete and verified by our clinical bioinformatician, the report is uploaded to your encrypted patient portal. A DHA-licensed genetic counsellor will then schedule a telehealth session (within 24 hours of report availability) to explain the findings, discuss the clinical significance, and recommend next steps. All data is handled under UAE PDPL and health data protection frameworks, ensuring your privacy and full compliance with genetic testing regulations.
UAE Regulatory & Data Privacy Adherence
Regulatory & Data Privacy Compliance
This test is performed under DHA facility license number 1143 and complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is never shared without explicit consent and is stored in encrypted, access-controlled servers. For more details, request our Data Protection Impact Assessment (DPIA) via WhatsApp.
ISO 9001:2015 Quality Management System – Certificate: INT/EGQ/2509DA/3139. All analytical processes are audited annually to meet DHA/MOHAP standards for genetic testing.
Clinical & Logistical Metadata
| Test Name | CUX2 Gene-Related Early Infantile Epileptic Encephalopathy Type 67 (EIEE67) – Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Peripheral whole blood, dried blood spot (FTA card) or extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) of CUX2 coding and splice regions |
| ICD-10-CM Code | G40.4 |
| LOINC Code | 90637-3 |
| DHA Facility License & Address | License No. 1143 • Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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