Test Price
2,800 AED✅ Home Collection Available
ZAP70 Gene Selective T‑cell Defect Genetic Test | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – ISO 9001:2015 accredited NGS platform delivering comprehensive coding region coverage.
- Premium Logistics – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM.
- Post‑Test Genetic Counselling – Mandatory telephonic consultation with variant interpretation and family risk assessment.
- Insurance – Direct Billing Verification via WhatsApp +971 54 548 8731.
This high‑resolution molecular assay replaces older single‑exon methods and is essential for definitive diagnosis, carrier screening, and guiding early therapeutic intervention for autosomal recessive severe combined immunodeficiency (SCID) caused by ZAP70 mutations.
Test Overview & Methodology
The ZAP70 gene selective T‑cell defect NGS test analyses the entire coding region and splice sites for pathogenic variants that abolish kinase activity, leading to selective CD8+ T‑cell lymphopaenia and severe immunodeficiency. Results are reported according to ACMG guidelines and include variant interpretation by molecular immunologists.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | Full gene NGS (Next Generation Sequencing) | Single‑exon Sanger sequencing |
| Gene Coverage | 100% coding region + splice sites | Targeted known mutations only |
| Diagnostic Yield | >99% for pathogenic variants | ~70‑80% (incomplete) |
| Turnaround Time | 3 – 4 Weeks | 2 – 3 Weeks |
Physician Insight & Safety Protocols
“As your consultant in medical genetics, I recognize the profound implications of a ZAP70 genetic diagnosis. This test provides definitive molecular evidence that, when correlated with clinical and immunological findings, directs critical interventions such as hematopoietic stem cell transplantation. Expert pre‑ and post‑test genetic counselling is essential to ensure informed decision‑making and accurate interpretation of results.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Medication Precautions
⚠ Important Medication Advisory: Do not discontinue prescribed medications or modify immunosuppressive therapy without consulting your physician. Genetic test results may influence treatment decisions only under full medical supervision. Always maintain current therapy until explicitly advised otherwise by your specialist.
Exclusion Criteria & Emergency Red Flags
- Not for asymptomatic general screening without a strong family history of ZAP70 deficiency or confirmed parental carrier status.
- Do not test during acute severe illness that requires urgent clinical stabilisation – postpone until the patient is medically stable.
- ER Red Flags: If you or your child exhibit high fever, respiratory distress, failure to thrive, or signs of overwhelming sepsis, seek emergency care immediately. This genetic test is elective and does not replace emergency evaluation.
- Minors: Testing requires informed consent from legal guardians and a pre‑test genetic counselling session complying with Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What exactly does the ZAP70 gene selective T‑cell defect test detect?
Our ZAP70 DNA test uses Next Generation Sequencing to detect pathogenic variants across the full coding region and splice sites. The assay identifies mutations that disrupt kinase activity, resulting in selective CD8+ T‑cell lymphopaenia and severe combined immunodeficiency. All variants are classified per ACMG standards and interpreted by molecular immunologists.
2. Who should consider ZAP70 genetic testing?
Individuals with unexplained severe infections, suspected SCID, or a documented family history of ZAP70 mutation should consider testing. Typical candidates include infants with failure to thrive, recurrent fungal or viral infections, absent thymic shadow on imaging, or proven lymphopaenia with low CD8+ counts. Carrier testing is offered to first‑degree relatives of a confirmed proband following pre‑test counselling.
3. How long do results take and what is the testing process?
Results are available within 3–4 weeks from sample receipt. The process begins with a pre‑test genetic counselling session to review family history and obtain informed consent. A peripheral whole‑blood sample is collected via VIP Mobile Phlebotomy at your home between 8 AM and 11 PM. After sequencing, a post‑test telephonic consultation is scheduled to explain the implications and guide next steps.
UAE Regulatory & Data Privacy Adherence
Legal Compliance & Data Protection Framework
- All genetic testing procedures comply with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) – genomic data is encrypted, stored locally on UAE servers, and never shared without explicit patient consent.
- Health information governance adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient safety and consent protocols follow Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – guaranteeing process excellence and quality management.
Clinical & Logistical Metadata
| Test Name | ZAP70 Gene Selective T‑cell Defect Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Cold‑Chain Home Collection available daily 8 AM – 11 PM) |
| Methodology Used | Next Generation Sequencing (NGS) – Full gene coding region + splice sites |
| ICD‑10‑CM Code | D81.7 |
| LOINC Code | 74698‑1 |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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