Test Price
2,800 AED✅ Home Collection Available
NFKB2 Gene Common Variable Immunodeficiency Type 10 (CVID10) Genetic Test in UAE | 2800 AED | DHA Licensed Diagnostics
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity – ISO 9001:2015 Certified NGS Processing
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available Daily 8 AM‑11 PM
Telephonic Post-Test Clinical Guidance – Expert Result Interpretation by Consultant Medical Geneticist
Direct Insurance Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
The NFKB2 Genetic Test sequences the entire NF-kappa-B2 gene using Next-Generation Sequencing (NGS) to detect pathogenic variants causing Common Variable Immunodeficiency Type 10 (CVID10). This multi‑system disorder is characterised by recurrent infections, skin manifestations, and anterior pituitary hormone deficiencies. Comprehensive NGS coverage combined with CNV analysis delivers 99.9% diagnostic sensitivity, enabling accurate differentiation from other primary immunodeficiencies and guiding targeted endocrinology and immunology management.
| Parameter | Our NFKB2 NGS Test | Closest Alternative (Limited Sanger Sequencing) |
|---|---|---|
| Precision & Coverage | Full gene sequencing + CNV analysis, 99.9% diagnostic sensitivity | Targeted exon analysis only; may miss deep intronic or CNV variants |
| Methodology | Next‑Generation Sequencing (NGS) with advanced bioinformatics | Sanger sequencing of selected exons |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks |
| Price (AED) | 2,800 | ~3,000 |
| Sample Type | Whole Blood, Extracted DNA, or FTA Card Specimen | Blood only |
Physician Insight & Safety Protocols
“The NFKB2 gene plays a pivotal role in both immune regulation and pituitary development. Identifying a pathogenic variant through comprehensive NGS sequencing allows clinicians to anticipate multisystem involvement—from recurrent sinopulmonary infections to adrenal insufficiency. I emphasise that all genetic findings must be correlated with clinical presentation and that hormone or immunosuppressant therapies should never be adjusted without specialist oversight.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
IMPORTANT PRECAUTION: Do not discontinue any prescribed medication, especially corticosteroids, hormone replacement therapy, or immunosuppressants, without consulting your treating physician. Abrupt cessation can precipitate life‑threatening adrenal crisis, particularly in patients with confirmed or suspected pituitary hormone deficiency. Always carry a medical alert card indicating your diagnosis and medication regimen.
Safety Exclusion Criteria & Emergency Red Flags
Exclusion Criteria for Home Collection
- Patients unable to provide informed consent; minors under 18 without legal guardian authorisation per UAE personal data protection regulations.
- Acute severe infection or haemodynamic instability requiring immediate medical intervention—home phlebotomy is deferred until clinical stabilisation.
Emergency Red Flags — Seek Immediate Care
- Sudden severe hypotension, confusion, vomiting, or signs of adrenal crisis—especially relevant if anterior pituitary hormone deficiency is known or suspected.
- Rapidly progressive skin lesions accompanied by fever, blisters, or mucosal involvement warranting urgent dermatology and immunology assessment.
Patient FAQ & Clinical Guidance
1. What is the NFKB2 gene common variable immunodeficiency type 10 genetic test?
Answer: The NFKB2 gene test detects mutations that cause CVID10, a primary immunodeficiency with endocrine and skin features. It uses Next‑Generation Sequencing to analyse the entire NFKB2 gene, identifying sequence variants and copy number changes that confirm the diagnosis. This test is critical for distinguishing CVID10 from other immunodeficiencies and guiding hormone replacement and infection prophylaxis strategies.
2. How is the NFKB2 genetic test performed and what is the turnaround time?
Answer: A simple blood sample, extracted DNA, or a single drop on an FTA card is analysed via NGS, with results delivered within 3 to 4 weeks. Our VIP mobile phlebotomy service visits at your convenience between 8 AM and 11 PM daily. The specimen is transported under ISO‑certified temperature‑controlled cold‑chain conditions to our laboratory, where expert bioinformatics interpretation completes the analysis within the stated timeframe.
3. What do my NFKB2 test results mean for my health and family?
Answer: A positive result confirms CVID10, enabling targeted endocrinology and immunology follow‑up. A negative result reduces but does not eliminate the possibility of other genetic immune defects. Family members may benefit from cascade screening since NFKB2 variants follow an autosomal dominant inheritance pattern. Our post‑test telephonic guidance session explains the results, reproductive options, and recommended surveillance. Always interpret results in conjunction with your specialist.
UAE Regulatory & Data Privacy Adherence
Your genetic data is processed under strict UAE federal data protection and healthcare information governance frameworks. This test complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, storage, and sharing of your personal and genetic information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensuring secure handling of digital health records and telemedicine interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – safeguarding patient consent, clinical safety, and practitioner accountability throughout the diagnostic pathway.
All laboratory processes are ISO 9001:2015 certified and conducted at DNA Labs UAE under DHA Facility License No. 1143. Your results are confidential and shared only with you and your referring physician.
Clinical & Logistical Metadata
| Test Name | NFKB2 Gene Common Variable Immunodeficiency Type 10 (CVID10) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card Specimen |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV Analysis |
| ICD-10-CM Code | D83.8, D83.9 |
| LOINC Code | 76881-0 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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