Test Price
2,800 AED✅ Home Collection Available
NCF2 Gene Chronic Granulomatous Disease Type 2 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity achieved through an ISO 9001:2015 accredited sequencing and bioinformatics pipeline.
- Premium Logistics: Hospital‑grade VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic Post‑Test Clinical Guidance by a DHA‑licensed Consultant Medical Genetics to contextualize your NCF2 results.
- Insurance & Billing: Direct Billing Verification available. Send your Emirates ID & insurance card via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced diagnostic assay employs Next‑Generation Sequencing (NGS) to analyze the complete coding and flanking intronic regions of the NCF2 gene. The test is designed to detect single nucleotide variants (SNVs), small insertions/deletions (indels), and large copy number variations (CNVs) with high analytical sensitivity and specificity. It provides a definitive molecular diagnosis for autosomal recessive, cytochrome b‑positive chronic granulomatous disease (CGD) type 2, enabling targeted immunology, dermatology, and haematology management.
| Feature | Our NGS NCF2 Test | Closest Alternative (Panel/Targeted Sanger) |
|---|---|---|
| Analytical Scope | Full gene sequencing + deletion/duplication analysis | Selected exons only; may miss deep intronic or regulatory variants |
| Methodology | NGS (Illumina platform, ISO 15189 validated) | Sanger sequencing – lower throughput and variant resolution |
| Turnaround Time | 3‑4 weeks | 4‑6 weeks or longer for multi-exon analysis |
| Price (AED) | 2800 AED | 2400‑3000 AED (limited genomic coverage) |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I emphasize that a definitive molecular diagnosis via comprehensive NCF2 sequencing must be integrated with the patient's clinical history, pedigree analysis, and neutrophil oxidative burst functional assays. A positive result facilitates early prophylactic antimicrobial therapy and evaluation for curative hematopoietic stem cell transplantation. However, a negative result does not exclude all CGD subtypes, and clinical correlation remains paramount."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory & Safety Protocols
⚠ Clinical Notice: Do not discontinue prescribed antimicrobial or immunosuppressive therapy without consulting your treating physician. This genetic test provides diagnostic clarification but does not replace continuous clinical monitoring and acute care management.
Exclusion Criteria & Precautions
- Exclusion criteria for testing: Patients who have received a blood transfusion within the last 4 weeks, or those presenting with active leukocytosis secondary to acute infection, as donor DNA may mask the endogenous genotype.
- Protection for minors: All sample collections for individuals under 18 years require informed, written consent from a legal guardian in full compliance with UAE data protection and healthcare regulations.
- Emergency Red Flags: If the patient develops high fever, rapidly enlarging abscess, severe lymphadenitis, or respiratory distress, proceed to the nearest emergency department immediately. Urgent infectious disease management takes precedence over elective genetic testing.
Patient FAQ & Clinical Guidance
1. Who should consider this NCF2 gene test?
This test is indicated for individuals with recurrent, severe bacterial or fungal infections, a family history suggestive of X-linked or autosomal recessive CGD, unexplained granuloma formation, or impaired nitroblue tetrazolium (NBT) test results. It is also appropriate for families seeking carrier testing or planning for preimplantation genetic diagnosis.
2. What does a positive NCF2 mutation result mean?
A positive result confirms the diagnosis of autosomal recessive cytochrome b‑positive chronic granulomatous disease type 2. This precise molecular diagnosis enables accurate prognosis, targeted prophylactic antibiotic and antifungal regimens, and life-saving hematopoietic stem cell transplantation planning where indicated.
3. How is the sample collected for this genetic test?
Our DHA‑licensed phlebotomists collect a small venous whole blood sample (3-5 mL in EDTA) or a finger‑prick FTA card in the comfort of your home. The specimen is transported via our temperature-controlled cold-chain logistics directly to the ISO 15189 accredited laboratory for analysis. Home collection services are available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to the UAE's comprehensive legal framework governing clinical genetic testing and patient data. All operations are conducted under DHA Facility License Number 1143.
- Data Protection: Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) ensuring the highest standards of patient data confidentiality and security.
- Health Information Governance: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for all digital health records and telemedicine consultations.
- Medical Liability & Consent: Informed consent procedures are rigorously aligned with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Quality Management: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), assuring stringent quality control across all pre‑analytical, analytical, and post‑analytical phases.
Clinical & Logistical Metadata
| Parameter | Specification |
|---|---|
| Test Name | NCF2 Gene Chronic Granulomatous Disease Type 2 Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Whole Blood (Peripheral, EDTA) or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS), Illumina Platform, ISO 15189 Validated |
| ICD-10-CM Code | D71 (Chronic granulomatous disease) |
| LOINC Code | 91281-3 (NCF2 gene sequencing) |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License No. 1143 |
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