Test Price
2,800 AED✅ Home Collection Available
IL21R Gene Immunodeficiency, Primary, Autosomal Recessive, IL21R‑Related Genetic Test | 2800 AED | DNA Labs UAE Dubai
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paired VIP Mobile Phlebotomy and ISO Certified Cold‑Chain Home Collection (daily 8 AM – 11 PM).
- Clinical Guidance: Post‑test telephonic consultation with a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This dedicated NGS test sequences the entire IL21R gene to identify pathogenic variants causing autosomal recessive IL21R‑related primary immunodeficiency—a disorder characterised by severe immune dysregulation, eczema, and recurrent infections.
| Feature | Our IL21R NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | Single‑gene deep coverage, >100× mean depth; Sanger confirmation of all pathogenic variants | Broad coverage but often lower depth (~50×) for IL21R; may miss deep intronic variants |
| Methodology | NGS (Next‑Generation Sequencing) with full gene analysis + deletion/duplication calling | Exome capture + NGS; data filtered for IL21R secondarily |
| Turnaround | 3–4 Weeks | 8–12 Weeks |
| Clinical Report | Focused report with immunologist interpretation, variant classification per ACMG, and family planning guidance | General whole exome report requiring secondary gene‑specific analysis |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I recognise that a positive IL21R variant report can be life‑changing—but it must be correlated with the patient’s full clinical picture, immunological workup, and family history. This test does not replace a thorough physical examination or the need for ongoing specialist care; it empowers early targeted intervention and informed family planning. Genetic data should never be the sole basis for treatment decisions.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⛔ Do not discontinue prescribed immunomodulators, corticosteroids, or antibiotics without consulting your doctor. Genetic testing informs, not dictates, therapeutic changes.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: This test is not indicated for acute febrile illness; active severe infection requires immediate emergency care. Minors must have parental/guardian consent as per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- ER Red Flags: Sudden high fever (>39.5°C), difficulty breathing, severe pain, or signs of sepsis demand an immediate hospital visit—do not wait for genetic results.
Patient FAQ & Clinical Guidance
1. What is the IL21R gene test, and why is it important?
This test analyses the entire IL21R gene to detect mutations causing autosomal recessive primary immunodeficiency, providing a definitive molecular diagnosis that guides treatment and family counselling.
2. How is the sample collected, and is home collection available?
A healthcare professional collects a small venous blood sample during a VIP mobile phlebotomy visit. Home collection is available daily from 8 AM to 11 PM, using a temperature‑controlled cold chain.
3. Why does the test take 3–4 weeks, and what happens during that time?
The 3–4 week period includes high‑fidelity NGS library preparation, sequencing, bioinformatic alignment, variant filtering, and Sanger validation of all pathogenic findings.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All genomic information is handled in compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your data is encrypted, access‑controlled, and never shared without explicit consent.
Clinical & Logistical Metadata
| Test Name | IL21R Gene Immunodeficiency, Primary, Autosomal Recessive, IL21R‑Related Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA) |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | D84.8 (Other specified immunodeficiencies) |
| LOINC Code | 94223-5 (IL21R gene full mutation analysis in Blood by NGS) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians