Test Price
2,800 AEDโ Home Collection Available
CD3D Gene Immunodeficiency Type 19 Genetic Test in UAE | 2800 AED | NGS Sequencing
Executive Summary & Core Metrics
Precision Genetic Analysis for Primary Immunodeficiency Diagnosis
- Diagnostic Sensitivity: >99.9% analytical accuracy via ISO-accredited next-generation sequencing for the full CD3D coding region including intron-exon boundaries.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all Dubai emirates.
- Post-Test Support: Complimentary telephonic clinical guidance provided by a consultant medical geneticist for result interpretation and family cascade testing recommendations.
- Insurance & Billing: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This comprehensive genetic test utilises next-generation sequencing (NGS) to detect pathogenic variants in the CD3D gene responsible for primary immunodeficiency type 19, a severe combined immunodeficiency (SCID)-like disorder. Early molecular diagnosis enables targeted clinical surveillance, prophylactic antimicrobial therapy, and timely evaluation for hematopoietic stem cell transplantation. The assay covers the full coding region, splice sites, and selected deep intronic regions with concurrent copy number variation (CNV) detection, delivering a definitive genomic result within a clinically actionable timeframe.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Analytical Precision | >99.9% sensitivity for CD3D full coding region, splice sites, and CNV detection | ~99% โ limited to exonic hotspots; separate deletion/duplication assays required |
| Methodology | Next-generation sequencing (NGS) with bioinformatic CNV calling and ACMG/AMP variant classification | Sanger sequencing โ single amplicon analysis, unable to detect CNVs in a single workflow |
| Turnaround Time | 3โ4 weeks (comprehensive clinical report with variant interpretation and family guidance) | 4โ6 weeks (requires separate deletion/duplication assays adding 2โ3 weeks) |
Physician Insight & Safety Protocols
โThe CD3D gene encodes the CD3 delta chain, a critical component of the T-cell receptor complex. Pathogenic variants disrupt T-cell development and function, leading to recurrent, life-threatening infections in early infancy. This NGS-based test offers a comprehensive, single-assay solution to confirm the diagnosis, enabling precise genetic counselling and informed decisions regarding immunotherapy or transplantation. Results must always be correlated with the patient's clinical presentation and immunological phenotype.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Clinical Advisory
โ ๏ธ Do not discontinue, alter, or initiate any prescribed medication, immunoglobulin therapy, or prophylactic regimen without direct consultation with your treating immunologist or primary physician. Genetic results provide complementary diagnostic information and must never replace clinical judgement or established treatment protocols.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: This non-urgent genetic test is not suitable for individuals with acute life-threatening infections, haemodynamic instability, or those unable to provide informed consent. Mandatory pre-test genetic counselling is required; sample collection may be deferred if the patient is clinically unstable or febrile at the time of the scheduled visit.
- Emergency Red Flags โ seek immediate medical attention if you or your child experience:
- Sudden high fever (>39ยฐC) accompanied by rigors or lethargy.
- Progressive respiratory distress, stridor, or wheezing unresponsive to bronchodilators.
- Signs of anaphylaxis including swelling of the lips, tongue, or throat, and generalised urticaria.
- New-onset confusion, seizures, or loss of consciousness.
Patient FAQ & Clinical Guidance
1. What is the CD3D gene immunodeficiency type 19 NGS test and why is it important?
This test analyses the CD3D gene using next-generation sequencing to identify disease-causing variants that lead to primary immunodeficiency type 19, a severe condition characterised by recurrent infections, failure to thrive, and increased risk of autoimmunity. Early and accurate genetic diagnosis enables clinicians to initiate tailored surveillance, prophylactic antibiotics, immunoglobulin replacement, and timely evaluation for curative haematopoietic stem cell transplantation.
2. What sample types are accepted and how should I prepare?
We accept whole blood in EDTA tubes, extracted DNA of verified quality, or a dried blood spot on an FTA card. No fasting is required. A certified phlebotomist will collect the sample during a scheduled home visit between 8 AM and 11 PM. Please provide a detailed clinical summary and, if available, a family pedigree from a pre-test genetic counselling session to optimise variant interpretation and cascade testing.
3. How are results reported and what do they mean for my family?
Results are issued as a physician-friendly PDF report with variants classified according to ACMG/AMP guidelines as pathogenic, likely pathogenic, variant of uncertain significance (VUS), likely benign, or benign. A complimentary telephonic consultation with our consultant medical geneticist is provided to explain the findings and their clinical implications. If a pathogenic variant is identified, first-degree relatives may benefit from targeted cascade testing to enable predictive counselling and early intervention.
4. How long does it take to get results and how will I receive them?
The turnaround time is 3 to 4 weeks from sample receipt in the laboratory. The comprehensive report includes the full CD3D gene sequencing data, CNV analysis, variant classification, clinical interpretation, and recommendations for family testing. Results are delivered via secure electronic portal and a physical copy can be couriered upon request.
5. Is genetic counselling recommended before and after the test?
Yes, pre-test genetic counselling is mandatory for this test to ensure informed consent, discuss the potential implications of findings including VUS results, and prepare the family for possible cascade testing. Post-test counselling is provided as a complimentary service to explain results and coordinate further care with a clinical immunologist.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights โ Fully Compliant with UAE Federal Law
All genetic data generated through this test is processed, stored, and transmitted in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. No genetic information is shared with third parties without explicit written consent. Clinical testing safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring that all diagnostic steps are performed under the highest standards of medical accountability and patient safety.
DNA Labs UAE is licensed by the Dubai Health Authority (DHA Facility License: 1143) and operates under ISO-accredited laboratory protocols. Your genomic data is encrypted, access-controlled, and retained only for the duration required by UAE health regulations.
Clinical & Logistical Metadata
| Test Name | CD3D Gene Immunodeficiency Type 19 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card blood spot |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV detection and ACMG/AMP variant classification |
| ICD-10-CM Code | D81.2 (Severe combined immunodeficiency with low or normal B-cell numbers) |
| LOINC Code | 82936-5 (CD3D gene mutation analysis in Blood or Tissue by Molecular genetics method) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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