Test Price
2,800 AED✅ Home Collection Available
CD27 Gene Lymphoproliferative Syndrome Type 2 (CD27 Deficiency) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
✓ 99.9% Diagnostic Accuracy via ISO 9001:2015 accredited laboratory processing using advanced Next Generation Sequencing (NGS) technology.
✓ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
✓ Physician Teleconsultation included for comprehensive result interpretation and genetic counseling.
✓ Direct Insurance Verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The CD27 Gene NGS Test is a definitive molecular diagnostic tool that screens the entire coding region of the CD27 gene for pathogenic variants causing lymphoproliferative syndrome type 2. This severe primary immunodeficiency is characterized by impaired T-cell dependent B-cell responses, chronic EBV viremia, and a high risk for lymphoma. This test empowers clinical decision-making from targeted surveillance to curative hematopoietic stem cell transplantation.
| Feature | DNA Labs UAE (NGS Full Gene) | Alternative (Sanger Selected Exons) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) – all exons & splice sites | Sanger sequencing of 2-3 common exons |
| Detection Rate | >99.9% sensitivity for substitutions, indels, CNVs | ~60-70% (misses rare/novel variants outside hotspots) |
| Turnaround Time | 21–28 Days | 4–6 Weeks |
| Cost (AED) | 2,800 | >3,500 |
| ISO Accreditation | Yes (Cert: INT/EGQ/2509DA/3139) | Variable |
| DHA Facility License | 1143 | Unknown |
Physician Insight & Safety Protocols
Clinical Insight from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403)
"Receiving a genetic diagnosis carries profound implications for the entire family. The CD27 NGS test provides a critical foundation for risk stratification and early intervention. It must always be interpreted within the full clinical and immunological context to guide decisions on surveillance, antiviral therapy, and potential hematopoietic stem cell transplantation. Our commitment is to deliver clarity and support throughout this complex diagnostic journey."
Medication Safety Advisory
⚠️ DO NOT DISCONTINUE ANY PRESCRIBED MEDICATION WITHOUT CONSULTING YOUR DOCTOR.
Abrupt cessation of immunosuppressants, antivirals, or immunoglobulin therapy may trigger severe disease flares or life-threatening infections.
Exclusion Criteria & Emergency Red Flags
Exclusion from Routine Home Draw:
- Inability to provide informed consent (patient or legal guardian).
- Pregnant individuals requiring specific genetic counseling before testing.
- Active severe infection with hemodynamic instability.
- Children under 1 year without pediatric phlebotomy clearance.
ER Red Flags (seek immediate care):
- Rapidly enlarging lymph nodes > 2 cm with B-symptoms (fever, night sweats, weight loss).
- Respiratory distress or stridor.
- Severe, uncontrolled infection or sepsis signs.
- Persistent fever >38.5°C unresponsive to antipyretics.
Patient FAQ & Clinical Guidance
1. What does a positive CD27 gene mutation mean?
A positive CD27 mutation confirms lymphoproliferative syndrome type 2, increasing risk for life-threatening EBV-driven lymphoproliferation and lymphoma. Follow-up immunological workup and genetic counseling are mandatory to assess disease severity and family implications.
2. Can this test be performed on children?
Yes, minors require parental consent under UAE law, and genetic counseling is mandatory before sample collection. Our pediatric phlebotomy team is trained for gentle draws using age-appropriate techniques and cold-chain preservation protocols.
3. How accurate is NGS compared to older methods?
Our NGS platform achieves >99.9% sensitivity, covering all exons and splice sites, surpassing single-exon Sanger sequencing in detection completeness. This method identifies deep intronic variants, large deletions, and complex rearrangements that older techniques miss.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and DHA-licensed (Facility No. 1143).
Data Privacy: All genetic data is processed and stored within UAE servers in compliance with national health data sovereignty rules. No third-party sharing without explicit patient consent.
Insurance & Billing: Direct insurance verification available via WhatsApp at +971 54 548 8731. Competitive self-pay rate: 2,800 AED inclusive of home collection and post-test teleconsultation.
Clinical & Logistical Metadata
| Test Name | CD27 Gene Lymphoproliferative Syndrome Type 2 (CD27 Deficiency) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 21–28 Days |
| Sample Type / Matrix | Peripheral Whole Blood or Saliva |
| Methodology Used | Next Generation Sequencing (NGS) |
| ICD-10-CM Code | D82.8 |
| LOINC Code | 90377-2 |
| DHA Facility License & Laboratory Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | License: 1143 |
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All reports reviewed by DHA-Certified physicians