Test Price
2,800 AED✅ Home Collection Available
TET2 Gene Myelodysplastic Syndrome Somatic Mutation NGS Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
99.9% Diagnostic Sensitivity – ISO 9001:2015 accredited laboratory processing using high-depth Next‑Generation Sequencing (NGS) with orthogonal Sanger confirmation. This test identifies acquired (somatic) mutations in the TET2 gene, critical for the diagnosis, prognosis, and therapeutic stratification of myelodysplastic syndromes.
Premium Logistics: VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM across all UAE emirates.
Clinical Guidance: Complimentary telephonic post‑test clinical correlation session with a DHA‑licensed consultant medical geneticist to interpret results in the context of your haematology work‑up.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The TET2 somatic mutation NGS test detects acquired variants in the TET2 gene, a key epigenetic regulator. In the UAE, this assay is used to subtype myelodysplastic syndromes, refine IPSS‑R risk scores, and guide eligibility for emerging targeted therapies. Our targeted sequencing panel covers all coding exons with a minimum depth of 500× unique reads, and all reportable variants are confirmed by Sanger sequencing.
| Feature | Our Test – TET2 Somatic NGS | Closest Alternative – Broad Myeloid Panel |
|---|---|---|
| Depth of Coverage | ≥500× unique reads across all TET2 coding exons | 100–300× (variable) |
| Method | Targeted NGS + Sanger validation for reportable variants | Multiplex PCR‑based NGS (50+ genes) |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Clinical Relevance | Focused on acquired TET2 variants; clear prognostic significance for MDS | Many genes; TET2 analysis may be diluted by lower depth and incidental findings |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I emphasise that a TET2 mutation alone does not diagnose MDS; it must be correlated with blood counts, bone marrow morphology, and cytogenetics. However, a positive result strongly refines risk stratification and may open avenues for clinical trial enrolment. Please rely on your haematologist‑oncology team to integrate this information into your personalised care plan.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice
Medication Adherence
Do not discontinue prescribed medication (e.g., erythropoiesis‑stimulating agents, iron chelators, or hypomethylating agents) without explicit instruction from your consultant. Genetic test results should always be interpreted in conjunction with your ongoing treatment regimen.
Safety & Exclusion Criteria
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Patients unwilling or unable to complete a pre‑test genetic counselling session; known severe anaemia (Hb <7 g/dL) where venipuncture may pose risk; active life‑threatening haemorrhage.
- Emergency Red Flags: If you develop sudden severe bleeding, uncontrolled infection, or acute chest pain, stop and seek emergency medical care immediately — do not wait for genetic results.
- Paediatric note: Federal Decree‑Law No. 4 of 2016 on Medical Liability requires guardian consent for minors; all data handled under PDPL.
Patient FAQ & Clinical Guidance
1. What is the TET2 gene somatic mutation test for myelodysplastic syndrome?
The TET2 gene mutation test detects acquired (somatic) mutations in the TET2 gene associated with myelodysplastic syndromes to guide diagnosis, prognosis, and targeted therapy decisions.
2. How long does it take to receive TET2 somatic NGS results in Dubai?
Results are typically finalised within 3 to 4 weeks from receipt of a properly collected peripheral blood or DNA sample at our ISO-accredited laboratory.
3. Do I need a genetic counselling session before this test?
Yes, a pre‑test genetic counselling session is mandatory to draw a family pedigree and explain the implications of a positive somatic mutation in the TET2 gene for your personal health and blood relatives.
4. What specimen type is required for this test?
Peripheral whole blood (8–10 mL in EDTA tube) or extracted genomic DNA (minimum 2 µg) is acceptable. For patients unable to provide blood, bone marrow aspirate may be used with prior consultation.
5. Is home collection available for this test?
Yes, our VIP mobile phlebotomy service is available daily from 8 AM to 11 PM across all UAE emirates, using temperature‑controlled cold‑chain transport to ensure sample integrity.
UAE Regulatory & Data Privacy Adherence
Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) · DHA Facility License 1143
Compliance: Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) · Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields · Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Code Mapping: ICD‑10‑CM D46.9, D46.2, D46.0 (MDS subtypes) · Z15.09 (genetic susceptibility) · LOINC: 86204-6 (TET2 gene targeted mutation analysis).
Data Integrity: All genetic data are encrypted and stored in‑country; results are disclosed only to the referring physician and the patient after verified consent.
Clinical & Logistical Metadata
| Test Name | TET2 Gene Myelodysplastic Syndrome (Somatic) Genetic Test – NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or extracted genomic DNA; VIP mobile phlebotomy available 8 AM–11 PM |
| Methodology Used | Targeted Next‑Generation Sequencing (NGS) with orthogonal Sanger confirmation |
| ICD-10-CM Code | D46.9, D46.2, D46.0, Z15.09 |
| LOINC Code | 86204-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 · Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE · DNA Labs UAE |
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