Test Price
2,800 AEDโ Home Collection Available
SLC13A5 Gene Early Infantile Epileptic Encephalopathy Type 25 (EIEE25) Genetic Test in UAE | 2,800 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO 15189:2022 accredited Next-Generation Sequencing (NGS) with full bioinformatic analysis and variant interpretation under the supervision of Dr. Lina O. Z. Quteineh.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection performed by DHA-licensed practitioners, available daily from 8 AM to 11 PM across all Emirates.
- Complimentary Clinical Guidance: Post-test telegenetic counseling session provided by Dr. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) to discuss results and family planning.
- Insurance Verification: Direct billing support and pre-authorization assistance via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SLC13A5 gene test screens for pathogenic variants causing early infantile epileptic encephalopathy type 25 (EIEE25), a severe neonatal-onset neurological disorder characterized by intractable seizures, profound developmental delay, and dystonia. This NGS-based assay provides a definitive molecular diagnosis, guiding clinical management and recurrence risk counseling for families.
| Feature | Our NGS EIEE25 Test (Gold Standard) | Closest Alternative (Legacy Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity for single nucleotide changes, indels, and CNVs | Limited to exonic hotspots; ~85% sensitivity |
| Methodology | Full gene NGS (Next-Generation Sequencing) with MLPA confirmation | Sanger sequencing of selected exons only |
| Turnaround Time | 3 to 4 weeks (expedited processing available for acute clinical cases) | 6 to 8 weeks |
Physician Insight & Safety Protocols
"As a Consultant Medical Geneticist, I recommend this targeted NGS analysis for any infant presenting with unexplained early-onset seizures refractory to standard anticonvulsants. A confirmed molecular diagnosis of EIEE25 allows for precise prognostication, tailored seizure management, and accurate recurrence risk counseling for the family. Nevertheless, all genetic findings must be interpreted within the full electroclinical context of the patient."
โ Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Critical Advisory for Clinical Management
Do not initiate, discontinue, or modify any prescribed antiepileptic medication based solely on genetic test results without direct consultation with the managing neurologist. Abrupt withdrawal of therapy may precipitate life-threatening status epilepticus. Genetic findings are adjunctive to continuous EEG monitoring and metabolic screening.
Exclusion Criteria for Home Collection
- Patients experiencing acute metabolic crisis or ongoing status epilepticus requiring hospital admission.
- Hemodynamic instability or severe respiratory compromise.
- Neonates currently admitted to the NICU at the time of request; specimen collection must be coordinated via inpatient referral.
Emergency Red Flags: In the event of a seizure lasting longer than 5 minutes, respiratory distress, or loss of consciousness, call 998 immediately.
Patient FAQ & Clinical Guidance
1. What does the SLC13A5 genetic test diagnose, and who should order it?
This test definitively confirms early infantile epileptic encephalopathy type 25 (EIEE25) by identifying pathogenic variants in the SLC13A5 gene. It is indicated for neonates and children with drug-resistant epilepsy, profound developmental delay, and dystonic movements. It is typically ordered by a pediatric neurologist or a medical geneticist following abnormal EEG and MRI findings.
2. How is the sample collected, and what preparation is required?
A standard peripheral whole blood draw or a painless dried blood spot onto an FTA card is required. No fasting or special preparation is necessary. A DHA-licensed phlebotomist will visit your home between 8 AM and 11 PM, ensuring temperature-controlled transport back to the laboratory.
3. When will I receive the results, and is genetic counseling provided?
Results are delivered within 3 to 4 weeks via a secure online portal. A complimentary telephonic or in-person genetic counseling session with Dr. Lina Quteineh is provided to interpret the clinical significance of the findings and to discuss implications for family members. Most major UAE insurers provide coverage for this test with prior approval. Send your insurance card via WhatsApp to +971 54 548 8731 for instant verification.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143. We strictly comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) regarding the collection, processing, and storage of your personal genomic data. All health information is transmitted and stored in full compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety protocols and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your data is encrypted and processed exclusively within UAE jurisdictions.
Clinical & Logistical Metadata
| Test Name | SLC13A5 Gene Early Infantile Epileptic Encephalopathy Type 25 (EIEE25) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with MLPA Confirmation |
| ICD-10-CM Code | G40.4 |
| LOINC Code | 87153-8 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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