Test Price
2,800 AED✅ Home Collection Available
RNASEH2B Gene Aicardi-Goutières Syndrome Type 2 Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance and result interpretation with a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced genetic test uses Next‑Generation Sequencing (NGS) to analyse the entire coding region of the RNASEH2B gene, providing a definitive molecular diagnosis for Aicardi‑Goutières Syndrome Type 2 (AGS2). The assay covers all coding exons and ±20 bp of flanking intronic regions, detecting single nucleotide variants, small insertions/deletions, and copy number changes with 99.9% analytical sensitivity and specificity.
| Feature | Our Test | Whole Exome Sequencing |
|---|---|---|
| Method | NGS of RNASEH2B gene only | NGS of all 20,000+ genes |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Precision | 99.9% analytical sensitivity & specificity for AGS2 | Lower specificity; high incidental finding risk |
| Clinical Actionability | Direct confirmatory diagnosis & familial screening | Often requires secondary analysis |
| Price | 2,800 AED | 6,500+ AED |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): “Aicardi‑Goutières syndrome type 2 is a rare interferonopathy that often presents in early infancy with severe neurological regression. While this RNASEH2B gene test provides a molecular gold standard for diagnosis, results must always be correlated with clinical findings such as neuroimaging and CSF interferon‑alpha levels. Pre‑ and post‑test genetic counselling is mandatory to address the implications for the patient and family, including recurrence risks and reproductive options.”
Safety & Pre-Test Advisory
This is an elective genetic diagnostic test and is not intended for acute emergency management. Patients with active systemic infections or unstable medical conditions should defer non‑urgent genetic testing until stabilised. Do not discontinue prescribed medication without consulting your treating physician—genetic results do not replace current treatment plans. A mandatory pre‑test genetic counselling session is conducted to draw a pedigree chart and document informed consent in compliance with UAE regulations.
Exclusion Criteria & Emergency Red Flags
- ER Red Flag: If the patient experiences acute encephalopathy, new‑onset seizures, loss of consciousness, or sudden neurological deterioration, seek emergency care immediately. Do not wait for test results.
- Patients with active systemic infections or unstable medical conditions should defer non‑urgent genetic testing until stabilised.
- Do not discontinue prescribed medication without consulting your treating physician — genetic results do not replace current treatment plans.
Patient FAQ & Clinical Guidance
1. How does this genetic test detect Aicardi‑Goutières syndrome type 2?
Snippet answer: This test uses Next‑Generation Sequencing to precisely analyze the RNASEH2B gene, detecting single nucleotide variants, indels, and copy number changes with 99.9% accuracy, enabling a definitive molecular diagnosis.
The assay covers all coding exons and ±20 bp of flanking intronic regions of RNASEH2B. Pathogenic variants, including those missed by older technologies, are identified and confirmed via Sanger sequencing. The result classifies the variant according to ACMG guidelines, directly informing prognosis, familial recurrence risk, and eligibility for clinical trials.
2. What sample is required and how is the home collection performed?
Snippet answer: You can provide a simple blood sample (whole blood, serum, or plasma), collected by our VIP mobile phlebotomy team across the UAE.
Our ISO‑certified cold‑chain courier service ensures sample integrity from your doorstep to our genomics lab. The process takes less than 15 minutes, and no fasting is required. A mandatory pre‑test genetic counselling session (telephonic or in‑clinic) is arranged to draw a pedigree chart and document informed consent, in compliance with UAE PDPL.
3. How long until results arrive and what post‑test support is provided?
Snippet answer: Turnaround time is 3–4 weeks; afterwards you receive a comprehensive genetic report reviewed by a consultant medical geneticist, along with a telephonic counselling session to interpret the results.
The final report details the variant classification, clinical correlation, and actionable recommendations. Our DHA‑licensed specialist will discuss the findings in a scheduled 30‑minute consultation, explaining implications for the patient, siblings, and future pregnancies. Direct billing verification and insurance pre‑approval assistance are available via WhatsApp at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
This service operates under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled with strict confidentiality. Clinical testing safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility holds ISO 9001:2015 certification, confirming international quality standards.
Clinical & Logistical Metadata
| Test Name | RNASEH2B Gene Aicardi-Goutières Syndrome Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Blood (Whole Blood, Serum, or Plasma) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G31.81 (Aicardi-Goutières syndrome) |
| LOINC Code | 83267-5 (Gene targeted mutation analysis in blood) |
| DHA Facility License & Laboratory Address | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License 1143 |
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All reports reviewed by DHA-Certified physicians