Test Price
2,800 AED✅ Home Collection Available
NDUFS3 Gene (Leigh Syndrome) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- ✓Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (8 AM – 11 PM).
- ✓Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The NDUFS3 gene encodes a core subunit of mitochondrial Complex I, and its pathogenic variants are a direct cause of Leigh syndrome, a severe progressive neurodegenerative disorder. This NGS-based test comprehensively sequences all coding exons and flanking intronic regions of the NDUFS3 gene, offering unparalleled accuracy for confirmation of clinical diagnosis, carrier screening, and prenatal risk assessment.
| Feature | Our NDUFS3 NGS Test | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) with high-depth coverage | Sanger Sequencing (targets only specific exons) |
| Diagnostic Sensitivity | ~99.9% for all variants (including intronic/exon boundaries) | ~90–95% (may miss deep intronic or regulatory variants) |
| Turnaround Time | 3 to 4 Weeks | 6–8 Weeks |
| Price (UAE) | 2,800 AED | 3,500–4,200 AED |
| Sample Types | Blood, Extracted DNA, FTA Card (one drop blood) | Blood only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), states: “The NDUFS3 test is a precise diagnostic instrument, yet it must be interpreted within the full clinical context including neurological examination, neuroimaging findings, and lactate/pyruvate ratios. A negative sequencing result does not eliminate mitochondrial disease; additional whole-exome or mitochondrial genome analysis should be considered. Always consult a clinical geneticist or metabolic specialist prior to making therapeutic decisions.”
⚠️ Advisory Notice
Do not discontinue prescribed medication without consulting your doctor. This genetic test is for diagnostic purposes only and does not replace ongoing clinical care.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: None for blood draw; however, minors require legal guardian consent in accordance with UAE personal data protection regulations. No test is performed on individuals unable to provide informed consent unless a legally authorized representative is present.
- Red Flags (Seek Immediate ER Care): If the patient exhibits acute respiratory distress, loss of consciousness, uncontrolled seizures, or rapid neurological deterioration, proceed to the nearest emergency department. This test does not manage acute crises.
Patient FAQ & Clinical Guidance
1. What is the NDUFS3 gene and how does it relate to Leigh syndrome?
The NDUFS3 gene encodes a critical subunit of mitochondrial Complex I, and its mutations cause Leigh syndrome, a devastating neurodegenerative disorder characterized by progressive loss of motor skills, seizures, and respiratory insufficiency.
2. Who should consider this NDUFS3 genetic test?
Individuals with suspected mitochondrial disease, children with developmental regression, ataxia, or elevated lactate, and families with history of Leigh syndrome should undergo testing. Prenatal testing and carrier screening are also available for at-risk couples.
3. What does the test result mean for my child’s health?
A positive NDUFS3 mutation confirms Leigh syndrome diagnosis and guides prognosis and family planning; a negative result may require further mitochondrial genome analysis to exclude other genetic causes.
UAE Regulatory & Data Privacy Adherence
UAE Regulatory Compliance & Data Privacy
This test is performed under DHA Facility License 1143, adhering to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted and stored within UAE borders. Home collection services are MOHAP‑licensed and follow ISO 9001:2015 cold‑chain protocols.
For requisition or insurance billing verification, WhatsApp: +971 54 548 8731
Clinical & Logistical Metadata
| Test Name | NDUFS3 Gene (Leigh Syndrome) Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Blood, Extracted DNA, FTA Card (one drop blood) |
| Methodology Used | Next Generation Sequencing (NGS) – High-depth coverage of all coding exons and flanking intronic regions |
| ICD-10-CM Code | G31.81 (Leigh syndrome), E88.49 (Other mitochondrial metabolism disorders) |
| LOINC Code | 55233-1 (Genetic analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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