Test Price
2,800 AEDโ Home Collection Available
KCNJ10 Gene SESAME Syndrome Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Clinical Excellence & Patient Trust Summary
- Accuracy Guarantee: >99.9% Diagnostic Sensitivity for Single Nucleotide Variants (SNVs) and small indels via ISO 9001:2015 accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance to contextualize results with the ordering physician's clinical findings.
- Insurance: Direct Billing Verification available. Submit your policy copy via WhatsApp at +971 54 548 8731.
This advanced genetic test sequences the entire coding region of the KCNJ10 gene using Next-Generation Sequencing (NGS) to diagnose SESAME syndrome with high precision. We ensure full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
Diagnostic Overview & Comparative Precision
This DNA test sequences the entire coding region of the KCNJ10 gene to identify pathogenic variants causing Seizures, Sensorineural deafness, Ataxia, Mental retardation, and Electrolyte imbalance (SESAME) syndrome. This molecular genetic test is the gold standard for precise molecular diagnosis.
| Feature | Our Test (NGS of KCNJ10) | Closest Alternative (Single Gene Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | >99.9% Sensitivity for SNVs & Indels (Full Exon Coverage) | ~99% Sensitivity (Focused Exonic Targets Only) |
| Methodology | Next Generation Sequencing (NGS) with Validation via Sanger | Sanger Sequencing Only |
| Turnaround Time | 3 to 4 Weeks (Comprehensive Analysis) | 4 to 6 Weeks |
Physician Insight & Safety Protocols
"A positive KCNJ10 result provides a molecular basis for the patient's complex neurological phenotype, but it must be integrated with renal and audiologic data. A negative result does not exclude the clinical diagnosis, necessitating a deeper investigation for copy number variants or non-coding regulatory mutations. I strongly advocate for pre- and post-test counselling to prepare the family for the genetic implications."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory on Medication Management
โ ๏ธ Important Medication Advisory:
Do not discontinue or adjust any prescribed antiepileptic medication, audiological device, or electrolyte management protocol without explicit consultation with your treating neurologist. This test is for diagnostic and prognostic clarity, not for acute therapeutic changes.
Patient Safety Exclusion Criteria & Emergency Red Flags
๐ฅ Exclusions & Urgent Situations
- Exclusion for Home Collection: Individuals currently experiencing acute seizures or status epilepticus; active, hemodynamically significant electrolyte imbalances (e.g., severe hypokalemia with ECG changes). These patients require hospital-based specimen collection in a monitored setting.
- Emergency Red Flags for Post-Test Period: If post-test genetic counselling reveals a variant of unknown significance (VUS) and you concurrently develop new-onset ataxia, intractable vomiting, or altered sensorium, proceed immediately to your designated neurology emergency facility.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the KCNJ10 test for my child's seizures and hearing loss?
This test establishes a definitive molecular diagnosis for SESAME syndrome by identifying disease-causing variants in the KCNJ10 gene, directly linking refractory seizures, sensorineural hearing loss, and electrolyte imbalances. A positive result anchors your child's multidisciplinary care plan, allowing your neurologist and nephrologist to tailor anti-epileptic drugs and monitor for potassium-wasting complications, moving from empirical symptom management to targeted disease-modifying surveillance for renal and auditory function.
2. How is my genetic data protected during this test under UAE law?
Your genetic data is rigorously protected under the UAE Personal Data Protection Law (PDPL) (Federal Decree-Law No. 45 of 2021) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, which prohibit using genetic information for discriminatory underwriting or employment decisions. We process your sample inside our ISO 9001:2015 certified facility under a unique barcode, ensuring de-linkage from direct identifiers, and your raw sequencing data is never shared with third parties without explicit, renewed consent as mandated by these regulations.
3. Can I get a refund if the genetic report shows a Variant of Uncertain Significance (VUS)?
A Variant of Uncertain Significance is a clinically expected and scientifically valid classification, not a laboratory error, thus standard billing applies as the analytical processes for detection and interpretation were fully executed. However, our comprehensive service includes complimentary re-analysis of your stored data at 12-month intervals against updated genomic databases, and your neurologist will receive a supplementary report if the VUS is reclassified to likely pathogenic, ensuring ongoing clinical surveillance at no additional sequencing cost.
UAE Regulatory & Data Privacy Adherence
All genetic testing and data handling at our facility comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your genetic information remains confidential and used solely for diagnostic purposes as authorized by you.
Clinical & Logistical Metadata
| Test Name | KCNJ10 Gene SESAME Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks (21โ28 calendar days) |
| Sample Type / Matrix | Whole Blood (Peripheral) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next Generation Sequencing (NGS) with Sanger validation |
| ICD-10-CM Code | E87.6 (Hypokalemia) โ primary manifestation; additional codes may apply |
| LOINC Code | 82146-7 (KCNJ10 gene mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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