Test Price
2,800 AED✅ Home Collection Available
KCNJ10 Gene SESAME Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين KCNJ10 لمتلازمة SESAME في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Clinical Excellence & Patient Trust Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity for Single Nucleotide Variants (SNVs) and small indels via ISO 9001:2015 accredited NGS processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM - 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance to contextualize results with the ordering physician's clinical findings.
- Insurance: Direct Billing Verification available. Submit your policy copy via WhatsApp at +971 54 548 8731.
ملخص تنفيذي: يقدم هذا التحليل الجيني المتقدم التسلسل الكامل لجين KCNJ10 باستخدام تقنية الجيل التالي (NGS) لتشخيص متلازمة SESAME بدقة عالية. نحن نضمن الامتثال الكامل للمرسوم بقانون اتحادي رقم 41 لسنة 2024 وقانون حماية البيانات الشخصية (PDPL) في دولة الإمارات العربية المتحدة، مع توفير خدمة سحب منزلي معتمدة ومريحة لضمان خصوصية المريض وسلامته القصوى.
Diagnostic Overview & Comparative Precision
This DNA test sequences the entire coding region of the KCNJ10 gene to identify pathogenic variants causing Seizures, Sensorineural deafness, Ataxia, Mental retardation, and Electrolyte imbalance (SESAME) syndrome. تحليل الجين هذا هو المعيار الذهبي للتشخيص الجزيئي الدقيق.
| Feature | Our Test (NGS of KCNJ10) | Closest Alternative (Single Gene Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | >99.9% Sensitivity for SNVs & Indels (Full Exon Coverage) | ~99% Sensitivity (Focused Exonic Targets Only) |
| Methodology | Next Generation Sequencing (NGS) with Validation via Sanger | Sanger Sequencing Only |
| Turnaround Time | 3 to 4 Weeks (Comprehensive Analysis) | 4 to 6 Weeks |
Physician Insight & Safety Protocol
"A positive KCNJ10 result provides a molecular basis for the patient's complex neurological phenotype, but it must be integrated with renal and audiologic data. A negative result does not exclude the clinical diagnosis, necessitating a deeper investigation for copy number variants or non-coding regulatory mutations. I strongly advocate for pre- and post-test counselling to prepare the family for the genetic implications."
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠️ Critical Medication Advisory:
Do not discontinue or adjust any prescribed antiepileptic medication, audiological device, or electrolyte management protocol without explicit consultation with your treating neurologist. This test is for diagnostic and prognostic clarity, not for acute therapeutic changes.
🏥 Patient Safety Exclusion Criteria & ER Red Flags
- Exclusion for Home Collection: Individuals currently experiencing acute seizures or status epilepticus; active, hemodynamically significant electrolyte imbalances (e.g., severe hypokalemia with ECG changes). These patients require hospital-based specimen collection in a monitored setting.
- Emergency Red Flags for Post-Test Period: If post-test genetic counselling reveals a variant of unknown significance (VUS) and you concurrently develop new-onset ataxia, intractable vomiting, or altered sensorium, proceed immediately to your designated neurology emergency facility.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the KCNJ10 test for my child's seizures and hearing loss?
This test establishes a definitive molecular diagnosis for SESAME syndrome by identifying disease-causing variants in the KCNJ10 gene, directly linking refractory seizures, sensorineural hearing loss, and electrolyte imbalances. A positive result anchors your child's multidisciplinary care plan, allowing your neurologist and nephrologist to tailor anti-epileptic drugs and monitor for potassium-wasting complications, moving from empirical symptom management to targeted disease-modifying surveillance for renal and auditory function.
يؤكد هذا التحليل التشخيص الجزيئي لمتلازمة سيسام عبر تحديد الطفرات المسببة للمرض في جين KCNJ10، مما يربط بشكل مباشر بين النوبات المستعصية وفقدان السمع الحسي العصبي واختلال توازن الكهارل ويرشد خطة الرعاية متعددة التخصصات.
2. How does the 2026 UAE healthcare law protect my genetic data privacy during this DNA?
Your genetic data is rigorously protected under the UAE Personal Data Protection Law (PDPL) and Federal Decree-Law No. 41 of 2024, which prohibits using genetic information for discriminatory underwriting or employment decisions. We process your sample inside our ISO 9001:2015 certified facility under a unique barcode, ensuring de-linkage from direct identifiers, and your raw sequencing data is never shared with third parties without explicit, renewed consent as mandated by Article 87 of the law concerning genomic data sharing.
تتم حماية بياناتك الجينية بصرامة بموجب قانون حماية البيانات الشخصية الإماراتي والمرسوم بقانون اتحادي رقم 41 لسنة 2024 الذي يحظر استخدام المعلومات الجينية لأغراض تمييزية في التأمين أو العمل، ولا تتم مشاركتها مع أطراف ثالثة دون موافقتك الصريحة.
3. Can I get a refund if the genetic report shows a Variant of Uncertain Significance (VUS)?
A Variant of Uncertain Significance is a clinically expected and scientifically valid classification, not a laboratory error, and thus standard billing applies as the analytical processes for detection and interpretation were fully executed. However, our comprehensive service includes complimentary re-analysis of your stored data at 12-month intervals against updated genomic databases, and your neurologist will receive a supplementary report if the VUS is reclassified to likely pathogenic, ensuring ongoing clinical surveillance at no additional sequencing cost.
النتيجة غير المحددة سريرياً (VUS) هي تصنيف علمي متوقع وليست خطأً مخبرياً، وتشمل خدمتنا إعادة تحليل مجانية ومراقبة مستمرة لتحديث التقرير في حال تغير التصنيف دون تكلفة إضافية.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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