Test Price
2,800 AED✅ Home Collection Available
GBA2 Gene Sequencing for Cerebellar Ataxia with Spasticity | DNA Labs UAE
Executive Summary & Core Metrics
Clinical Overview for UAE Patients
- Diagnostic Precision: 99.9% sensitivity via ISO 9001:2015 accredited Next-Generation Sequencing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: Temperature-controlled home collection (8 AM – 11 PM) by certified VIP mobile phlebotomists across Dubai and Abu Dhabi.
- Integrated Care: Telephonic post-test genetic counseling session with a DHA-licensed specialist included in the 2,800 AED investment.
- Insurance & Billing: Direct billing verification and insurance support available via WhatsApp at +971 54 548 8731.
2,800 AED
All-inclusive: collection, sequencing, report & genetic counselling
Test Overview & Methodology
This test screens the entire coding region of the GBA2 gene using Next-Generation Sequencing (NGS) to identify pathogenic variants responsible for autosomal recessive cerebellar ataxia with spasticity (SPG46/SCAR17). Within 3 to 4 weeks, a DHA-accredited laboratory delivers a definitive molecular diagnosis that empowers your neurologist to tailor surveillance, physiotherapy, and genetic family planning. The analysis includes robust bioinformatics pipelines validated under ISO 9001:2015 standards.
| Feature | DNA Labs UAE NGS Test | Standard Sanger Sequencing |
|---|---|---|
| Genomic Coverage | Full gene coverage including SNVs, indels, and copy number variants | Single-exon analysis; high probability of missing deep intronic or large structural rearrangements |
| Methodology | NGS with ISO 9001:2015 validated bioinformatics pipeline | Capillary electrophoresis with limited multiplex capability |
| Turnaround Time | 3–4 Weeks (includes genetic counselling session) | 6–8 Weeks typical laboratory turnaround |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I emphasize that a genetic finding in the GBA2 gene provides critical insight into the etiology of cerebellar ataxia and spasticity, but it must be interpreted alongside a detailed neurological examination and comprehensive family history to ensure diagnostic accuracy and appropriate genetic counselling. DNA Labs UAE is committed to providing evidence-based post-test guidance for every patient.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed antispasticity agents, muscle relaxants, or anti-epileptics without explicit consultation with your doctor. Abrupt withdrawal can cause severe rebound spasticity or seizures.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or documented systemic infection on the day of sample collection — reschedule sample collection after full recovery.
- Severe coagulopathy (INR > 2.0) or thrombocytopenia (platelets < 50,000/µL) — must be cleared by a haematologist before venipuncture.
- Inability to provide informed consent (for minors, a legal guardian must be present to provide consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Seek emergency medical care immediately if you develop sudden worsening of ataxia, loss of consciousness, intractable vomiting, or signs of intracranial hypertension after blood draw.
Patient FAQ & Clinical Guidance
1. What is the turnaround time for the GBA2 genetic test in the UAE?
The complete process from home collection to the certified clinical report takes 3 to 4 weeks. Using Next-Generation Sequencing at our DHA-licensed facility (License 1143), the DNA extraction, sequencing, bioinformatics analysis, and comprehensive report generation are performed. A mandatory 30-minute tele-counselling session with a clinical geneticist is scheduled upon report release.
2. Which specialist should I consult for a positive GBA2 mutation?
The primary specialist is a Consultant Neurologist, ideally with expertise in movement disorders or neurogenetics. Additionally, a Clinical Geneticist coordinates family counselling and risk assessment for siblings and offspring. A DHA-licensed Genetic Counsellor helps interpret the inheritance pattern and guide family planning decisions. UAE-based management integrates physiotherapy, antispasticity medications, and regular multi-disciplinary follow-up at authorised hospitals.
3. Is home sample collection safe for a patient with severe spasticity?
Yes. Our certified mobile phlebotomy team is trained to handle patients with limited mobility and severe spasticity using stabilising support cushions and a rapid, single-venipuncture technique. The sample is immediately placed in a validated temperature-controlled medical courier box (2–8°C) that transmits real-time GPS-logged data to our lab, fully compliant with UAE PDPL for data privacy and health information security.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to the UAE’s highest standards for medical data privacy and laboratory practice. Our genetic testing protocols are fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility operates under the direct regulation of the Dubai Health Authority (DHA Facility License Number: 1143).
Clinical & Logistical Metadata
| Test Name | GBA2 Gene Sequencing (Cerebellar Ataxia with Spasticity) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS), ISO 9001:2015 Certified |
| ICD-10-CM Code | G11.4 (Hereditary Spastic Paraplegia) |
| LOINC Code | 82327-0 (Chromosome analysis for constitutional disorder) |
| DHA Facility License & Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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