Test Price
2,800 AEDโ Home Collection Available
DNAL4 Gene (Mirror Movements Type 3) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189:2022 accredited NGS processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic post-test clinical guidance in result interpretation by DHA-licensed genetic counsellors.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This targeted next-generation sequencing (NGS) test examines the entire coding region of the DNAL4 gene to detect pathogenic variants responsible for congenital mirror movements type 3 (CMM3). The assay provides definitive molecular confirmation for patients with bilateral, involuntary synkinetic hand movements, guiding neurological management and family planning. The method employs high-coverage Illumina NovaSeq sequencing with Sanger confirmation.
| Feature | Our Test (DNAL4 NGS โ DNA Labs UAE) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | Targeted deep sequencing of DNAL4 gene, >100x coverage | Broad exome-wide analysis, lower per-gene coverage |
| Methodology | Illumina NovaSeq NGS, Sanger confirmation | Same NGS platform but data filtered for multiple genes |
| Turnaround Time | 3-4 weeks | 6-8 weeks |
| Interpretation | Gene-specific clinical report with DNAL4 variant classification | Incidental findings possible, may require additional counselling |
Physician Insight & Safety Protocols
โAs a genetic consultant, I emphasize that targeted DNAL4 sequencing is essential for confirming CMM3 and differentiating it from other movement disorders. Results must always be interpreted alongside a complete neurological examination and family pedigree. Genetic counselling is mandatory to discuss inheritance patterns, recurrence risks, and potential implications for family members.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory & Precautions
โ ๏ธ Medication Warning
Do not discontinue any prescribed neurological medication without consulting your physician. Abrupt cessation can lead to dangerous withdrawal symptoms or worsening of underlying conditions. Always discuss medication changes with your treating neurologist.
Safety Exclusion Criteria & Emergency Red Flags
Test Exclusion Criteria:
- Acute febrile illness or systemic infection (reschedule until recovered).
- Inability to provide informed consent.
- Recent blood transfusion (within 2 weeks) โ may interfere with germline DNA analysis.
Seek Emergency Care If:
- Sudden loss of coordination or new neurological deficit.
- Severe, unrelenting headache with vomiting.
- Rapid progression of mirror movements interfering with daily function.
Patient FAQ & Clinical Guidance
1. What is the DNAL4 gene mirror movements type 3 test used for?
This targeted genetic test is indicated for children and adults with involuntary symmetry of hand movements, helping neurologists distinguish congenital mirror movements type 3 (CMM3) from other movement disorders. It provides definitive molecular confirmation and guides genetic counselling regarding inheritance patterns and family planning.
2. How is the sample collected and what preparation is required?
A simple blood draw, FTA card finger-prick, or previously extracted DNA sample is required. A mandatory pre-test genetic counselling session is needed to draw a family pedigree and obtain informed consent. No fasting is required, but patients must provide a detailed clinical history of mirror movements and any neurological symptoms.
3. What is the turnaround time and cost, and is it covered by insurance in UAE?
Standard reporting time is 3-4 weeks from sample receipt. The test is priced at 2,800 AED. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731. DNA Labs UAE is ISO 9001:2015 certified and accepted by major UAE insurers under neurological genetic testing coverage.
4. What does a positive or negative result mean?
A positive result confirms a pathogenic variant in the DNAL4 gene linked to CMM3. A negative result does not rule out other genetic causes. In all cases, results must be reviewed by a geneticist or neurologist, and genetic counselling is required to discuss implications for the patient and family members.
UAE Regulatory & Data Privacy Adherence
Data Protection & Healthcare Compliance
DNA Labs UAE strictly adheres to the UAEโs Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and stored within secure UAE-based servers. Patient consent and clinical safety protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Our facility is regulated by the Dubai Health Authority (DHA) under license number 1143 and complies with all applicable health information privacy regulations. Test results are shared only with the referring physician and the patient, ensuring complete confidentiality.
Clinical & Logistical Metadata
| Test Name | DNAL4 Gene (Mirror Movements Type 3) Genetic Test |
| Price (AED) | 2,800.00 |
| Turnaround Time | 3-4 weeks |
| Sample Type / Matrix | Peripheral blood, FTA card, or extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) โ Illumina NovaSeq with Sanger confirmation |
| ICD-10-CM Code | Z13.5 (Encounter for genetic screening), R27.8 (Other lack of coordination) |
| LOINC Code | 94825-7 (DNA sequencing of entire coding region of gene) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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