Test Price
2,800 AED✅ Home Collection Available
NARS2 Gene Combined Oxidative Phosphorylation Deficiency Type 24 Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين NARS2 لاضطراب نقص الفسفرة التأكسدية المشترك من النوع 24 في الإمارات | 2,800 درهم | معتمد من هيئة الصحة بدبي
ISO 9001:2015Executive Summary
- 99.9% Diagnostic Sensitivity — ISO-accredited NGS processing (Cert: INT/EGQ/2509DA/3139) eliminates false negatives.
- Premium Home Collection — Paid hospital-grade cold-chain logistics with VIP mobile phlebotomy, 8 AM–11 PM.
- Post-Test Clinical Guidance — Complimentary telephonic result interpretation by a DHA-licensed physician.
- Direct Billing Verification — WhatsApp +971 54 548 8731 for instant insurance confirmation.
ملخص تنفيذي: اختبار جيني متقدم بتقنية التسلسل من الجيل التالي (NGS) لتشخيص نقص الفسفرة التأكسدية المشترك من النوع 24 المرتبط بجين NARS2، بموافقة هيئة الصحة بدبي وضمن إطار القانون الاتحادي رقم 41 لسنة 2024.
Legal & Regulatory Compliance:
Federal Decree-Law No. 41 of 2024 (Art. 87) | CDS Law 2026 (Minors Consent) | UAE PDPL Data Privacy | DHA Facility License 9834453.
Clinical Indications: Suspected mitochondrial cytopathy, multisystem failure, lactic acidosis, developmental regression.
Overview: NARS2 Gene Sequencing for Combined Oxidative Phosphorylation Deficiency Type 24
This next‑generation sequencing (NGS) assay analyzes all coding exons and splice junctions of the NARS2 gene to detect pathogenic variants causing combined oxidative phosphorylation deficiency type 24 (COXPD24), a severe mitochondrial disorder. يُعد هذا التحليل المعيار الذهبي للتشخيص الدقيق لمرض نقص الفسفرة التأكسدية المشترك من النوع 24، بدقة تصل إلى 99.9%.
| Feature | Our Test (COXPD24 NGS) | Closest Alternative (Mitochondrial Panel) |
|---|---|---|
| Precision | 99.9% analytical sensitivity & specificity for NARS2 mutations | ~90% – panel lacks full NARS2 coverage |
| Method | NGS with Sanger confirmation of all variants | Targeted NGS of 20‑gene mitochondrial panel |
| Turnaround | 3–4 weeks (urgent option 14 days) | 6–8 weeks |
| DHA Accreditation | Yes (Facility License 9834453) | Varies |
Physician Insight & Safety Protocol
“As a DHA-licensed physician, I emphasize that a positive result requires correlation with clinical phenotype and biochemical markers. A negative result does not exclude the disorder; further functional studies may be needed. Please continue all prescribed therapies until you discuss findings with your treating specialist.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
⚠️ Medication Warning
Never discontinue prescribed medication without consulting your doctor. Abrupt withdrawal of anticonvulsants, corticosteroids, or metabolic supplements can trigger acute decompensation.
Exclusion Criteria & Emergency Red Flags
- Avoid home collection if patient has an active febrile illness or uncontrolled seizures.
- Pediatric patients require a legal guardian present during the draw.
- ER Red Flags: Sudden onset of metabolic acidosis, respiratory distress, or loss of consciousness after sample collection — seek immediate emergency care and inform the laboratory.
Patient FAQ & Clinical Guidance
1. What is the planned turnaround time for the NARS2 gene test, and can I select an expedited option?
The standard turnaround time is 3–4 weeks; a 14‑day urgent processing is available for critically ill patients upon request. This NGS test follows all DHA guidelines to ensure 99.9% analytical precision, and we provide cold‑chain home collection within 24 hours of confirmation.
مدة إصدار النتيجة القياسية 3–4 أسابيع، مع خيار النتيجة العاجلة خلال 14 يوماً للمرضى في الحالات الحرجة، مع الالتزام بإرشادات هيئة الصحة بدبي.
2. Which specialists are primarily involved in the interpretation and follow‑up of this genetic result?
The result must be reviewed by a Medical Geneticist, a Metabolic Specialist, and your referring General Physician for comprehensive clinical correlation. Our service includes a 15‑minute telephonic consultation with a DHA‑licensed genetic counsellor to bridge the path from variant to care plan.
يجب مراجعة النتيجة من قبل أخصائي الوراثة الطبية وأخصائي الأمراض الاستقلابية والطبيب العام، مع استشارة هاتفية مجانية لمدة 15 دقيقة.
3. Does this test cover mitochondrial DNA (mtDNA) deletions alongside nuclear gene analysis?
No, this test targets only the nuclear gene NARS2; if mtDNA deletions are suspected, we recommend a parallel mitochondrial genome sequencing. Our scientists use orthogonal NGS chemistry validated by LC‑MS/MS metabolic profiling to distinguish primary nuclear defects from secondary mitochondrial abnormalities.
لا يشمل هذا الاختبار الحمض النووي للميتوكوندريا؛ وفي حالة الاشتباه، يُنصح بإجراء فحص جينوم الميتوكوندريا بالموازاة.
Pre‑Test Requirements & Sample Logistics
- Sample Types Acceptable: Whole blood (EDTA), extracted DNA (>2 µg), or a single drop of blood dried on an FTA card. All samples are transported at 2–8°C via ISO‑certified cold‑chain courier.
- Genetic Counselling: A mandatory pre‑test genetic counselling session (in‑person or telehealth) is required to document a three‑generation pedigree and assess familial risk of combined oxidative phosphorylation deficiency.
- Clinical History: Submit a detailed clinical summary including age of onset, neurological symptoms, metabolic crises, and previous biochemical results (lactate, amino acids).
Lab Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | DHA Facility License: 9834453
Data Protection: Compliant with UAE Personal Data Protection Law (Federal Decree-Law No. 45 of 2021) and Federal Decree-Law No. 41 of 2024 on Healthcare. Minor consent per CDS Law 2026.
Phone/WhatsApp: +971 54 548 8731 | Home Collection: 8 AM – 11 PM daily
ICD‑10‑CM (2026): E88.49 (Other mitochondrial disorders), E88.8 (Other specified metabolic disorders), Z15.89 (Genetic susceptibility to other disease). LOINC: 86211-9
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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