Test Price
4,500 AEDโ Home Collection Available
Mitochondrial Mutation Detection Comprehensive Panel in UAE | 4,500 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% accuracy via ISO 9001:2015 certified laboratory
- Turnaround Time: Results delivered within 5 working days
- Genomic Coverage: Whole mitochondrial DNA (16.6 kb) plus over 300 nuclear genes associated with mitochondrial disease
- Clinical Support: Free post-test telephone consultation by a consultant medical geneticist
- Insurance Verification: Direct coverage check via WhatsApp: +971545488731
- Home Collection: VIP mobile phlebotomy with temperature-controlled cold-chain logistics, available daily 8 AM to 11 PM
Test Overview & Methodology
This comprehensive panel uses next-generation sequencing (NGS) to interrogate the entire mitochondrial genome and a curated panel of over 300 nuclear genes known to cause mitochondrial disorders. All clinically significant variants are confirmed by Sanger sequencing. The test is indicated for pediatric and adult patients presenting with unexplained neurological deterioration, myopathy, cardiomyopathy, or multisystem involvement, especially where maternal inheritance or elevated lactate suggests mitochondrial cytopathy.
| Feature | Our Test | Closest Alternative (Sanger Single Gene) |
|---|---|---|
| Methodology | NGS + Sanger confirmation | PCR + Sanger (limited genes) |
| Genomic Coverage | Full mtDNA + 300+ nuclear genes | Single gene or hot-spot panel |
| Turnaround Time | 5 working days | 10โ14 working days |
| Clinical Interpretation | Included with post-test guidance | Report only |
Physician Insight & Safety Protocols
โThe mitochondrial genome is highly polymorphic and requires deep NGS coverage to distinguish pathogenic mutations from benign variants. This panel delivers that depth and includes nuclear gene analysis crucial for diagnosing nuclear-encoded mitochondrial disorders. Results must always be integrated with clinical, biochemical, and imaging data. A negative result does not exclude mitochondrial disease if strong clinical suspicion remains. We recommend involving a clinical geneticist or neurologist in all case interpretations.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Safety Protocols
- Written consent from the patient or legal guardian is mandatory before sample collection, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- If the patient has received a blood transfusion or exchange transfusion within the last two weeks, postpone testing for at least two weeks to avoid false results.
- Do not discontinue or adjust any prescribed medication without consulting the treating physician. This genetic test is not a substitute for ongoing clinical monitoring.
- Ensure a completed Genomics Clinical Information Requisition Form (Form 20) is provided by the referring clinician.
๐จ Emergency Red Flags: Sudden vomiting, lethargy, seizures, altered consciousness, or severe acidosis require immediate emergency room evaluation before any sample collection.
Exclusion Criteria
- This test is not performed on minors without written consent from a parent or legal guardian and a referral from a pediatrician, as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Exclude patients currently in acute metabolic crisis โ proceed to emergency care immediately.
- Sample collection is contraindicated if the patient has had a bone marrow transplant or hematopoietic stem cell transplant unless specifically discussed with the laboratory.
Patient FAQ & Clinical Guidance
1. What is the Mitochondrial Mutation Detection Comprehensive Panel, and who needs it?
This panel sequences the entire mitochondrial DNA and over 300 nuclear genes to detect pathogenic mutations causing mitochondrial disorders such as MELAS, Leigh syndrome, Kearns-Sayre syndrome, and other respiratory chain deficiencies. It is recommended for patients with progressive neurological symptoms, muscle weakness, cardiomyopathy, or multi-organ involvement, especially when family history suggests maternal inheritance. Pediatricians and neurologists use it to confirm a diagnosis and guide management.
2. How much does the test cost, and is it covered by insurance?
The cost is 4,500 AED. This includes advanced NGS technology, full mitochondrial genome coverage, Sanger confirmation of variants, and a clinical post-test consultation with a medical geneticist. Most UAE insurance providers cover genetic testing when medically indicated. We offer direct verification of your coverage via WhatsApp: +971545488731.
3. How is the sample collected, and what preparations are needed?
A 4 mL venous blood sample is collected in a lavender-top EDTA tube and must be shipped refrigerated (2โ8ยฐC) โ never frozen โ to preserve DNA integrity. No fasting is required. A Genomics Clinical Information Requisition Form (Form 20) must be completed by the referring physician. Our VIP mobile phlebotomy service with temperature-controlled cold-chain logistics is available daily from 8 AM to 11 PM for home collection.
UAE Regulatory & Data Privacy Adherence
This service is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed and stored in accordance with UAE health data privacy standards. The laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and operates under the oversight of the Dubai Health Authority (DHA) and UAE Ministry of Health and Prevention (MOHAP).
Operated by DNA Labs UAE. DHA Facility License Number: 1143.
Clinical & Logistical Metadata
| Test Name | Mitochondrial Mutation Detection Comprehensive Panel |
| Price (AED) | 4,500 |
| Turnaround Time | 5 working days |
| Sample Type / Matrix | Peripheral whole blood (4 mL lavender-top EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | E88.49 (Mitochondrial metabolism disorders, unspecified) |
| LOINC Code | 101376-0 (Mitochondrial DNA genome sequencing) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians