Test Price
1,100 AED✅ Home Collection Available
MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes) Mutation Detection Test in UAE | 1100 AED | DHA Licensed
Executive Summary & Core Metrics
This test delivers 99.9% diagnostic sensitivity for the m.3243A>G mutation via ISO 9001:2015 accredited molecular genetics laboratory, with VIP mobile phlebotomy and temperature-controlled cold-chain home collection (available daily from 8 AM to 11 PM). Includes telephonic post-test clinical guidance and direct insurance billing verification via WhatsApp. The service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent follows Federal Decree-Law No. 4 of 2016 on Medical Liability.
Test Overview & Methodology
The MELAS mutation detection test analyzes the mitochondrial genome for the pathogenic m.3243A>G variant in the MTTL1 gene, the most common cause of this multisystemic disorder. Offered at 1100 AED with a 5-day turnaround, it surpasses broader panels by delivering targeted, rapid, and cost-effective molecular confirmation essential for clinical management. The methodology employs PCR amplification followed by Sanger sequencing, providing analytical sensitivity exceeding 99% for the targeted variant.
| Parameter | Our Test | Whole Mitochondrial Genome Sequencing |
|---|---|---|
| Methodology | PCR + Sanger Sequencing | Next-Generation Sequencing (NGS) |
| Analytical Sensitivity | >99% for m.3243A>G | ~98% for point mutations; higher chance of variants of uncertain significance |
| Turnaround Time | 5 days (Mon–Fri) | 14–21 days |
| Price | 1100 AED | 2800–3500 AED |
Physician Insight & Safety Protocols
“A positive MELAS mutation result provides a concrete molecular anchor for diagnosis, yet it must be interpreted alongside clinical features such as short stature, seizures, and lactic acidemia. I strongly recommend discussing results with a neurologist or clinical geneticist experienced in mitochondrial disorders. Critically, patients should not discontinue any prescribed medications—especially anticonvulsants or metabolic supplements—without explicit physician guidance.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety & Clinical Monitoring
Do Not Stop Prescribed Therapy
Patients undergoing this genetic test must continue all prescribed treatments, including antiepileptic drugs, coenzyme Q10, L-carnitine, and other metabolic supplements. Any adjustment should only occur after consultation with the treating physician. Abrupt cessation can precipitate metabolic crises or stroke-like episodes.
Exclusion Criteria & Emergency Red Flags
- Acute metabolic crisis with severe lactic acidosis (pH <7.1) — stabilize first before testing.
- Asymptomatic minors without informed consent from a clinical geneticist and legal guardian, in accordance with UAE regulations.
- Patients on anticoagulants with INR >3.0 — defer collection until INR is within therapeutic range.
- If you experience sudden worsening of weakness, stroke-like episodes, or seizures, seek emergency medical attention immediately; this test does not replace urgent neurological care.
Patient FAQ & Clinical Guidance
1. What is the MELAS mutation detection test?
The MELAS mutation detection test identifies the m.3243A>G pathogenic variant in the MTTL1 gene through PCR and Sanger sequencing, providing a definitive molecular diagnosis in suspected mitochondrial encephalomyopathy cases. The test is performed on a peripheral blood sample collected under strict cold-chain conditions.
2. How is the test performed in the UAE?
A certified phlebotomist collects a 4 mL whole blood sample in an EDTA tube at your home (available daily 8 AM to 11 PM). The specimen is transported in validated temperature-controlled cold-chain packaging to our ISO 9001:2015 accredited laboratory. Results are reported within 5 working days via secure electronic delivery.
3. Is this test covered by UAE insurance?
Many UAE medical insurers cover this test under hereditary neurometabolic disorder panels when ordered by a physician. We offer direct billing verification via WhatsApp at +971 54 548 8731 before sample collection. Please check with your provider for specific policy coverage.
UAE Regulatory & Data Privacy Adherence
This test is conducted in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled under strict confidentiality protocols. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes) Mutation Detection |
| Price (AED) | 1,100 AED |
| Turnaround Time | 5 working days (Sunday–Thursday) |
| Sample Type / Matrix | Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM–11 PM |
| Methodology Used | PCR amplification followed by Sanger Sequencing for m.3243A>G variant |
| ICD-10-CM Code | E88.41 (MELAS syndrome) |
| LOINC Code | 58221-6 (MELAS mutation detection) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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ISMS 27001:2022
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