Test Price
1,200 AED✅ Home Collection Available
Leigh Syndrome Mitochondrial Mutation Detection Test in UAE | DNA Labs UAE | 1200 AED
Executive Summary & Core Metrics
- ✓Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-accredited Next-Generation Sequencing (NGS) and confirmatory PCR.
- ✓Premium Logistics: VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily 8 AM – 11 PM.
- ✓Clinical Guidance: Complimentary post-test tele-consultation with a DHA-licensed consultant medical geneticist.
- ✓Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- ✓Price: 1,200 AED — all-inclusive with home collection and genetic counselling.
Test Overview & Methodology
This advanced genetic test analyses the entire mitochondrial genome (mtDNA) using PCR-based enrichment and high-coverage Next-Generation Sequencing to identify pathogenic variants linked to Leigh syndrome — a progressive neurometabolic disorder. The assay supports accurate diagnosis, carrier detection, and informed family planning. All workflows are validated against ISO 15189 standards and conducted at the DNA Labs UAE facility in Dubai Healthcare City.
| Feature | DNA Labs UAE Test | Closest Alternative |
|---|---|---|
| Methodology | NGS of entire mitochondrial genome + confirmatory PCR | Single-gene PCR (MT‑ATP6 only) |
| Diagnostic Sensitivity | 99.9% (validated against international reference datasets) | ~85% (limited gene coverage) |
| Turnaround Time | Report by Friday if sample received by Monday 9 AM | 10–14 working days |
| Home Collection | Included (VIP phlebotomy, cold chain) | Not offered |
| Post-test Consultation | Free tele-guidance by consultant medical geneticist | Additional charge |
| Price | 1,200 AED | 900–1,500 AED (variable) |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I recognise that Leigh syndrome presents with severe, progressive neurological decline. This test provides a definitive molecular diagnosis through comprehensive mitochondrial genome analysis, which — when correlated with clinical and biochemical findings — empowers families with crucial prognostic and reproductive options. A negative result does not exclude other inherited metabolic disorders; therefore clinical correlation and multidisciplinary evaluation remain essential.”
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory on Medication and Test Interpretation
Do not discontinue or adjust any prescribed medication without consulting your treating physician. Genetic test results must not be used as a sole basis for treatment decisions. Always integrate molecular findings with full clinical assessment.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients with active bleeding disorders or inability to undergo venipuncture. Do not attempt collection if the patient is in acute metabolic crisis — seek emergency care first.
- Seek immediate emergency room (ER) attention if the patient or child develops: sudden loss of consciousness, intractable seizures, severe respiratory distress, or signs of stroke-like episodes.
- Red Flags for hospital admission: lactic acidosis, hypothermia, persistent vomiting, or rapid neurological deterioration.
Patient FAQ & Clinical Guidance
1. What is Leigh syndrome mitochondrial mutation detection?
This test detects mitochondrial DNA mutations responsible for Leigh syndrome, enabling precise diagnosis and genetic counseling. It targets the entire mitochondrial genome using high-depth NGS after PCR enrichment, identifying both common and rare pathogenic variants. Results provide families with a clear molecular basis for the condition and options for reproductive planning.
2. How is the sample collected and what are the requirements?
Sample collection requires 4 mL of whole blood in a lavender-top EDTA tube, refrigerated shipping at 2–8 °C (never frozen), and a completed Genomics Clinical Information Requisition Form (Form 20). Our VIP mobile phlebotomist visits your home at a scheduled time; the sample is transported under temperature-controlled cold-chain logistics directly to our DHA-licensed laboratory.
3. What is the turnaround time and how will I receive results?
Results are available by Friday when the sample is submitted by Monday 9 AM. Reports are delivered digitally via a secure download link, and a consultant medical geneticist will contact you to explain the findings and their clinical implications.
4. Is home collection available for this test?
Yes. Because the specimen is standard peripheral whole blood, our VIP mobile phlebotomy and temperature-controlled cold-chain home collection service is available daily from 8 AM to 11 PM, including weekends and public holidays.
5. Can this test be used for prenatal or carrier screening?
The test is designed for diagnostic confirmation in symptomatic individuals and carrier detection in at-risk family members. For prenatal applications, please discuss with your genetic counsellor; alternative sample types (e.g., amniotic fluid or chorionic villus) require prior laboratory coordination.
UAE Regulatory & Data Privacy Adherence
This service fully complies with the following UAE healthcare and data protection mandates:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — all patient data are encrypted, access-controlled, and stored on secure servers within the UAE.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — governs the secure handling of electronic health records and telemedicine interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — establishes the framework for clinical safety, informed consent, and professional accountability in diagnostic testing.
- DHA Standards for Molecular Diagnostics — the laboratory adheres to all Dubai Health Authority guidelines for genetic testing, including quality assurance and result reporting.
DNA Labs UAE is accredited under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and holds DHA Facility License No. 1143. All molecular workflows follow validated NGS QA/QC protocols and are subject to regular external proficiency testing.
Clinical & Logistical Metadata
| Test Name | Leigh Syndrome Mitochondrial Mutation Detection |
| Price (AED) | 1,200 AED |
| Turnaround Time | Report by Friday if sample received by Monday 9 AM |
| Sample Type / Matrix | Whole blood (4 mL lavender-top EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) of entire mitochondrial genome + confirmatory PCR |
| ICD-10-CM Code | G31.82 (Leigh syndrome), E88.4 (Mitochondrial metabolism disorder), Z14.8 (Genetic susceptibility to other disease) |
| LOINC Code | 93360-1 (Mitochondrial DNA full gene analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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