Test Price
2,800 AEDโ Home Collection Available
UQCRQ Gene Mitochondrial Complex III Deficiency Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139). Premium logistics include VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Post-test telephonic clinical guidance is provided for result interpretation. Insurance direct billing verification via WhatsApp at +971 54 548 8731. This comprehensive Next Generation Sequencing assay targets the full coding region of the UQCRQ gene to diagnose mitochondrial complex III deficiency, a rare inherited disorder causing progressive neurological and multisystem symptoms. The test is optimized for the UAEโs diverse genetic background and consanguineous family structures.
Test Overview & Methodology
The UQCRQ Gene NGS Test identifies pathogenic variants responsible for mitochondrial complex III deficiency, a rare autosomal recessive disorder that presents with progressive neurological decline, myopathy, and metabolic crises. This assay uses full-gene next generation sequencing with deletion and duplication analysis to cover all coding exons and splice sites, providing a definitive molecular diagnosis. A positive result confirms the diagnosis and guides targeted management and family planning; a negative result does not exclude mitochondrial disease and may require further investigation.
| Feature | DNA Labs UAE NGS Test | Closest Alternative |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity and specificity with confirmatory analysis | Variable sensitivity with single-gene Sanger sequencing |
| Methodology | Full-gene NGS with deletion and duplication analysis | Targeted mutation panels only |
| Turnaround Time | 3 to 4 weeks | 6 to 12 weeks |
| Home Collection | VIP Mobile Phlebotomy 8 AM to 11 PM cold-chain certified | Usually unavailable |
| Post-Test Genetic Counseling | Free telephonic consultation included | Additional fee or not offered |
Physician Insight & Safety Protocols
โFrom a medical genetics perspective, this NGS test offers robust detection of pathogenic UQCRQ variants with high analytical validity. However, a positive finding must always be integrated with full clinical evaluation and formal genetic counseling before any management decisions are made. A negative result does not fully exclude mitochondrial disorder, and additional investigations may be warranted. Our multidisciplinary team is dedicated to supporting patients and families throughout this diagnostic process.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Important Medication Notice
Do not stop any prescribed medication without consulting your treating physician. Genetic test results are not a substitute for ongoing clinical management. Always follow the advice of your healthcare provider regarding medication adjustments.
Patient Safety: Exclusion Criteria & Emergency Red Flags
Exclusion Criteria for Home Collection:
- Active febrile illness with temperature of 38 ยฐC or higher within 24 hours of collection
- Acute neurological crisis including seizure, status epilepticus, or stroke-like episode
- Known active infection or immunosuppressive therapy that may compromise sample integrity
- Patient unable to provide informed consent or lacking a legally authorized representative
ER Red Flags โ Seek Immediate Medical Attention if:
- Sudden worsening of muscle weakness or loss of consciousness
- Severe lactic acidosis symptoms such as rapid breathing, confusion, or vomiting
- Chest pain, irregular heartbeat, or severe headache
- New-onset seizures or prolonged focal neurological deficits
Patient FAQ & Clinical Guidance
1. What is the purpose of the UQCRQ gene NGS test and who should consider it?
This test detects mutations in the UQCRQ gene that cause mitochondrial complex III deficiency, a condition marked by progressive neurological decline, myopathy, and metabolic crises. Individuals with a family history of mitochondrial disease or unexplained multisystem symptoms should consider genetic screening. The NGS platform evaluates all coding exons and splice sites to deliver a definitive molecular diagnosis, facilitating targeted management and family planning. In the UAE, this test is particularly relevant for consanguineous families where recessive disorders are more frequent.
2. How is the sample collected and why does the test take 3 to 4 weeks?
A certified phlebotomist collects a small volume of whole blood via venipuncture during a home visit, or you may submit pre-extracted DNA on an FTA card. The 3 to 4 week turnaround time accounts for comprehensive NGS sequencing, bioinformatic analysis, manual variant classification, and clinical report review by our medical team. This rigorous process meets ISO 9001:2015 standards and UAE regulatory requirements, ensuring accuracy for life-altering clinical decisions.
3. Will my insurance cover the 2800 AED cost and how do I verify?
Many UAE insurance plans cover genetic testing when medically justified. We provide direct billing verification via WhatsApp at +971 54 548 8731. Simply send your insurance card and the referring physician request, and our team will confirm coverage within hours. For out-of-pocket payments, a detailed invoice with ICD-10 coding is issued to facilitate reimbursement claims. We adhere strictly to UAE data protection regulations for all personal information.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring that all patient data is processed lawfully, stored securely, and used only for diagnostic purposes. We also adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, which governs the safe handling of health information and electronic medical records. Clinical testing safety and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, guaranteeing that every test is performed with the highest standards of care and transparency.
Clinical & Logistical Metadata
| Test Name | UQCRQ Gene Mitochondrial Complex III Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (venipuncture) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Full-gene next generation sequencing with deletion and duplication analysis |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 48018-6 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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