Test Price
2,800 AED✅ Home Collection Available
TWNK Gene MTDPS7 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Precision: 99.9% sensitivity for TWNK pathogenic variants via ISO 9001:2015 certified NGS (Illumina NovaSeq), validated to DHA standards.
- Sample Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection for whole blood, FTA card, or extracted DNA. Available daily 8 AM – 11 PM.
- Clinical Support: Complimentary post-test telephonic genetic correlation with a DHA-licensed consultant to contextualize results.
- Billing: Direct insurance verification via WhatsApp +971 54 548 8731. All major UAE networks accepted.
Test Overview & Methodology
The TWNK gene test is a definitive Next-Generation Sequencing (NGS) analysis for mitochondrial DNA depletion syndrome type 7 (MTDPS7), a severe neurogenetic disorder. It precisely identifies pathogenic variants in the TWNK gene, enabling early clinical intervention, family planning, and tailored neurological management. Laboratory analysis is conducted at DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE, under DHA Facility License 1143.
| Comparison Factor | TWNK NGS Gene Test | Whole Exome Sequencing Alternative |
|---|---|---|
| Precision | Full TWNK gene sequencing with >100× coverage; detects SNVs, indels, CNVs | Variable coverage often <30×; may miss deep intronic variants or CNVs |
| Methodology | Illumina NovaSeq NGS; ISO 9001:2015 validated; DHA-standard bioinformatics pipeline | Generic WES pipelines; incidental findings policy adds complexity |
| Turnaround Time | 3–4 weeks (expedited reporting available for critical cases) | 6–8 weeks, often with extended counselling wait |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Genetics, I recognize the profound implications of confirming a TWNK mutation for your child’s neurological presentation. This NGS-based test delivers definitive molecular evidence, yet results must always be interpreted alongside clinical examination and full family pedigree. Never adjust or cease any prescribed therapy or introduce supplements without first consulting your managing physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Safety Advisory
Pre-Test Precautions
Venipuncture is a low-risk procedure; however, disclose all anticoagulant medications and bleeding tendencies to the phlebotomist. For paediatric patients weighing below 2.5 kg, an FTA card or pre-extracted DNA sample is recommended instead of venous blood draw. Ensure the patient is haemodynamically stable and afebrile before sample collection.
Exclusion Criteria & Emergency Red Flags
Contraindications for Sample Collection
- Acute unstable illness with haemodynamic compromise – defer testing until clinical stabilisation.
- Known severe coagulopathy contraindicating venipuncture – consult haematologist before proceeding.
- Emergency Indicators (activate 998 or attend nearest ER immediately):
- New-onset seizure activity, loss of consciousness, or signs of metabolic crisis (tachypnoea, persistent vomiting, lethargy).
Patient FAQ & Clinical Guidance
1. What is the TWNK Gene MTDPS7 test used for?
This test identifies pathogenic mutations in the TWNK gene that cause mitochondrial DNA depletion syndrome type 7 (MTDPS7). It confirms the molecular diagnosis, distinguishes MTDPS7 from other mitochondrial encephalopathies, and informs prognosis, targeted therapies, and reproductive counselling.
2. How is the test performed and what sample type is required?
A DHA-licensed phlebotomist collects 2–5 ml of whole blood in an EDTA tube, a single drop on an FTA card, or you may submit previously extracted genomic DNA. All collection methods are minimally invasive and require no special preparation. Our mobile phlebotomy service operates daily from 8 AM to 11 PM.
3. What is the turnaround time and total cost in the UAE?
Results are delivered within 3–4 weeks from sample receipt. The all-inclusive price of 2,800 AED covers home phlebotomy, cold-chain transport, NGS analysis, bioinformatics interpretation, and a post-test tele-counselling session with a genetics consultant. No hidden fees apply.
4. Will my insurance cover this genetic test?
We provide direct billing verification for all major UAE insurance networks. Send your policy details via WhatsApp to +971 54 548 8731, and our billing team will confirm coverage and any copayment obligations before sample collection.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights
All genetic data is processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License 1143 and operates under ISO 9001:2015 certification. Your genetic information is encrypted, access-controlled, and never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | TWNK Gene (MTDPS7) Genetic Test – Next-Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), FTA Card, or Extracted Genomic DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina NovaSeq, >100× coverage, ISO 9001:2015 |
| ICD-10-CM Code | E88.49 |
| LOINC Code | 81247-9 |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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