Test Price
2,800 AED✅ Home Collection Available
SUCLG1 Gene Sequencing Test for Mitochondrial DNA Depletion Syndrome with Methylmalonic Aciduria in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary telephonic Post-Test Clinical Guidance for result interpretation by qualified genetic counselors.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the full coding region of the SUCLG1 gene to detect pathogenic variants responsible for Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Type with Methylmalonic Aciduria — a severe, autosomal recessive neurometabolic disorder. Designed for neurologists, medical geneticists, and at-risk families across the Emirates, this test delivers definitive molecular diagnosis within 3 to 4 weeks, enabling early intervention and informed family planning.
| Feature | Our Test — DNA Labs UAE | Closest Alternative (Sanger Sequencing / Single-Gene) |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) — Full Gene Coverage | Sanger Sequencing — Exon-by-Exon; Limited Coverage |
| Diagnostic Sensitivity | 99.9% for SNVs, Indels & Copy Number Variants | ~85-90%; Misses deep intronic & CNV variants |
| Turnaround Time | 3–4 Weeks | 6–10 Weeks |
| Sample Type | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) | Whole Blood Only |
| Genetic Counseling | Included — Pedigree Chart & Pre/Post-Test Session | Often Not Included |
| Regulatory Compliance | DHA Licensed (Facility #1143), ISO 9001:2015, UAE PDPL | Variable |
Physician Insight & Safety Protocols
Note from Ms. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) — "A positive SUCLG1 result confirms the molecular etiology of your or your child's condition, but it is essential to correlate these findings with the full clinical picture, including neurological examination and metabolic profiling. Genetic results provide clarity, yet they must be interpreted within the broader context of your family history and biochemical markers. Our multidisciplinary team is here to support you every step of the way."
Advisory Medication Warning
Critical Pretreatment Safety Advisory
⚠️ Critical Notice: Do not discontinue any prescribed medication without consulting your physician. Certain medications — including valproic acid, barbiturates, and specific statins — may exacerbate mitochondrial dysfunction and should be reviewed by your treating neurologist before any changes are made.
All patients must complete a mandatory medication disclosure form prior to sample collection to identify potential interactions with mitochondrial metabolism.
Exclusion Criteria & ER Red Flags
Exclusion Criteria
- Recent blood transfusion (within 2 weeks) — may cause sample contamination
- Active systemic infection with fever >38.5°C — reschedule until resolved
- Inability to provide informed consent (legal guardian required for minors per UAE PDPL standards)
- Unstable clinical condition requiring immediate critical care intervention
ER Red Flags — Seek Immediate Medical Attention
- Acute metabolic decompensation: vomiting, lethargy, tachypnea, or altered consciousness
- Seizure activity or status epilepticus
- Rapid neurological deterioration with loss of motor milestones
- Signs of liver failure: jaundice, coagulopathy, hypoglycemia
Patient FAQ & Clinical Guidance
1. What does the SUCLG1 genetic test detect, and who should consider it?
This test detects pathogenic variants in the SUCLG1 gene responsible for mitochondrial DNA depletion syndrome, encephalomyopathic type with methylmalonic aciduria, a severe autosomal recessive disorder. It is indicated for infants and children presenting with hypotonia, developmental regression, lactic acidosis, methylmalonic aciduria, and progressive neurological deterioration, as well as for asymptomatic siblings and extended family members seeking carrier status determination. Adults with unexplained mitochondrial myopathy and a compatible biochemical profile may also benefit.
2. How is the test performed, what sample is required, and how long do results take?
A certified phlebotomist collects a small volume of whole blood in an EDTA tube, or alternatively a single drop of blood on an FTA card, using a near-painless finger-stick method suitable even for neonates. Extracted DNA from a prior sample is also accepted. The laboratory employs Next-Generation Sequencing (NGS) with Illumina platform chemistry, achieving 100x average read depth across all coding exons and splice-site junctions, with bioinformatic analysis aligned to GRCh38/hg38 reference genome. Results are delivered in a comprehensive clinical report within 3 to 4 weeks.
3. Is this test covered by insurance, and how does home collection work in the UAE?
We offer direct insurance billing verification via WhatsApp at +971 54 548 8731, and our VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection service operates daily from 8 AM to 11 PM across all seven Emirates. A trained mobile phlebotomist arrives at your location with all necessary equipment, including temperature-controlled transport containers and DHA-compliant labeling materials. The entire home visit typically takes under 20 minutes, and strict infection control protocols are followed. Self-pay options at 2800 AED are also available with instant digital invoice generation.
4. What preparation is needed before providing a sample for this genetic test?
A mandatory Genetic Counseling session is required prior to sample collection to draw a comprehensive pedigree chart of family members affected by SUCLG1-associated Mitochondrial DNA Depletion Syndrome with Methylmalonic Aciduria. Patients must disclose all current medications, supplements, and recent illnesses. For Whole Blood collection, standard venipuncture is performed using an EDTA tube. FTA Card collection requires only a single drop of blood and is suitable for neonates and patients with difficult venous access. All samples are transported under ISO-certified cold-chain conditions.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: This laboratory operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic information is processed, stored, and transmitted under strict encryption and access control protocols. Clinical testing and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The facility is ISO 9001:2015 Certified (Certificate Number: INT/EGQ/2509DA/3139) and holds a valid DHA Facility License (Number: 1143). Patients retain absolute ownership of their genetic data; results are released exclusively to the ordering physician and the patient or legal guardian, and no genomic data is shared with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | SUCLG1 Gene Sequencing Test for Mitochondrial DNA Depletion Syndrome with Methylmalonic Aciduria |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) — Full Coding Region & Splice-Site Junctions |
| ICD-10-CM Code | E88.49 (Other mitochondrial metabolism disorders) |
| LOINC Code | 94233-3 (SUCLG1 gene targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians