Test Price
2,800 AED✅ Home Collection Available
SUCLG1 Gene Genetic Test for Mitochondrial DNA Depletion Syndrome (Encephalomyopathic Type with Methylmalonic Aciduria) in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SUCLG1 لمتلازمة استنفاد الحمض النووي للميتوكوندريا (النوع الدماغي العضلي مع البيلة الميثيل مالونية) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary — ملخص تنفيذي
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Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139). — دقة تشخيصية بنسبة 99.9% عبر معالجة معتمدة وفق معيار ISO.
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Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Logistics & VIP Mobile Phlebotomy (8 AM – 11 PM daily).
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Clinical Guidance: Complimentary telephonic Post-Test Clinical Guidance for result interpretation by qualified counselors.
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Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Overview
This advanced Next-Generation Sequencing (NGS) test analyzes the full coding region of the SUCLG1 gene to detect pathogenic variants responsible for Mitochondrial DNA Depletion Syndrome, Encephalomyopathic Type with Methylmalonic Aciduria — a severe, autosomal recessive neurometabolic disorder. يكشف هذا الاختبار الجيني المتقدم عن الطفرات الممرضة في جين SUCLG1 المسؤولة عن متلازمة استنفاد الحمض النووي للميتوكوندريا من النوع الدماغي العضلي.
Designed for neurologists, medical geneticists, and at-risk families across the Emirates, this test delivers definitive molecular diagnosis within 3 to 4 weeks, enabling early intervention and informed family planning in full compliance with UAE Federal Decree-Law No. 41 of 2024 (Art. 87) and the 2026 CDS Law for Minors.
| Feature | Our Test — DNA Labs UAE | Closest Alternative (Sanger Sequencing / Single-Gene) |
|---|---|---|
| Methodology | NGS (Next-Generation Sequencing) — Full Gene Coverage | Sanger Sequencing — Exon-by-Exon; Limited Coverage |
| Diagnostic Sensitivity | 99.9% for SNVs, Indels & Copy Number Variants | ~85-90%; Misses deep intronic & CNV variants |
| Turnaround Time | 3–4 Weeks | 6–10 Weeks |
| Sample Type | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) | Whole Blood Only |
| Genetic Counseling | Included — Pedigree Chart & Pre/Post-Test Session | Often Not Included |
| Regulatory Compliance | DHA Licensed (Facility #9834453), ISO 9001:2015, UAE PDPL | Variable |
Physician Insight & Safety Protocol
Note from Dr. PRABHAKAR REDDY (DHA License: 61713011) — "A positive SUCLG1 result confirms the molecular etiology of your or your child's condition, but it is essential to correlate these findings with the full clinical picture, including neurological examination and metabolic profiling. Genetic results provide clarity, yet they must be interpreted within the broader context of your family history and biochemical markers. Please know that you are not alone on this journey — our multidisciplinary team is here to support you every step of the way."
Safety Protocol & Medication Warning
⚠️ Critical Notice: Do not discontinue any prescribed medication without consulting your physician. Certain medications — including valproic acid, barbiturates, and specific statins — may exacerbate mitochondrial dysfunction and should be reviewed by your treating neurologist before any changes are made.
Exclusion Criteria
- Recent blood transfusion (within 2 weeks) — may cause sample contamination
- Active systemic infection with fever >38.5°C — reschedule until resolved
- Inability to provide informed consent (legal guardian required for minors per CDS Law 2026)
- Unstable clinical condition requiring immediate critical care intervention
ER Red Flags — Seek Immediate Medical Attention
- Acute metabolic decompensation: vomiting, lethargy, tachypnea, or altered consciousness
- Seizure activity or status epilepticus
- Rapid neurological deterioration with loss of motor milestones
- Signs of liver failure: jaundice, coagulopathy, hypoglycemia
Pre-Test Requirements & Medication Disclosure
A mandatory Genetic Counseling session is required prior to sample collection to draw a comprehensive pedigree chart of family members affected by SUCLG1-associated Mitochondrial DNA Depletion Syndrome with Methylmalonic Aciduria. Patients must disclose all current medications, supplements, and recent illnesses. For Whole Blood collection, standard venipuncture is performed using an EDTA tube. FTA Card collection requires only a single drop of blood and is suitable for neonates and patients with difficult venous access. All samples are transported under ISO-certified cold-chain conditions.
Patient FAQ & Clinical Guidance
Q1: What does the SUCLG1 Genetic Test detect, and who should consider it?
This test detects pathogenic variants in the SUCLG1 gene responsible for mitochondrial DNA depletion syndrome, encephalomyopathic type with methylmalonic aciduria, a severe autosomal recessive disorder. It is indicated for infants and children presenting with hypotonia, developmental regression, lactic acidosis, methylmalonic aciduria, and progressive neurological deterioration, as well as for asymptomatic siblings and extended family members seeking carrier status determination. Adults with unexplained mitochondrial myopathy and a compatible biochemical profile may also benefit.
يكشف هذا الاختبار عن الطفرات الممرضة في جين SUCLG1 المسؤولة عن متلازمة استنفاد الحمض النووي للميتوكوندريا من النوع الدماغي العضلي مع البيلة الميثيل مالونية. يُنصح به للرضع والأطفال الذين يعانون من نقص التوتر العضلي، والتراجع النمائي، والحماض اللاكتيكي، والتدهور العصبي التدريجي، وكذلك للأشقاء غير المصابين بأعراض وأفراد الأسرة الممتدة لتحديد حالة الحمل الجيني.
Q2: How is the test performed, what sample is required, and how long do results take?
A certified phlebotomist collects a small volume of whole blood in an EDTA tube, or alternatively a single drop of blood on an FTA card, using a near-painless finger-stick method suitable even for neonates. Extracted DNA from a prior sample is also accepted. The laboratory employs Next-Generation Sequencing (NGS) with Illumina platform chemistry, achieving 100x average read depth across all coding exons and splice-site junctions, with bioinformatic analysis aligned to GRCh38/hg38 reference genome. Results are delivered in a comprehensive clinical report within 3 to 4 weeks.
يقوم أخصائي سحب دم معتمد بجمع كمية صغيرة من الدم الكامل في أنبوب EDTA، أو بدلاً من ذلك قطرة دم واحدة على بطاقة FTA باستخدام طريقة وخز الإصبع شبه غير المؤلمة والمناسبة حتى لحديثي الولادة. يتم تسليم النتائج في تقرير سريري شامل خلال 3 إلى 4 أسابيع.
Q3: Is this test covered by insurance, and how does home collection work in the UAE?
We offer direct insurance billing verification via WhatsApp at +971 54 548 8731, and our hospital-grade home collection service operates daily from 8 AM to 11 PM across all seven Emirates with fully ISO-certified cold-chain logistics. A trained mobile phlebotomist arrives at your location with all necessary equipment, including temperature-controlled transport containers and DHA-compliant labeling materials. The entire home visit typically takes under 20 minutes, and strict infection control protocols are followed. Self-pay options at 2800 AED are also available with instant digital invoice generation.
نقدم خدمة التحقق المباشر من تغطية التأمين عبر واتساب على الرقم +971545488731، وتعمل خدمة التجميع المنزلي ذات المستوى الاستشفائي يومياً من الساعة 8 صباحاً حتى 11 مساءً في جميع الإمارات السبع مع لوجستيات سلسلة تبريد معتمدة بالكامل وفقاً لمعيار ISO. يتوفر خيار الدفع الذاتي بقيمة 2800 درهم.
UAE Regulatory Compliance & Data Privacy
✅ This laboratory operates under Federal Decree-Law No. 41 of 2024 (Article 87) concerning the regulation of genetic testing and genomic data handling within the United Arab Emirates. All genetic information is processed, stored, and transmitted in strict accordance with the UAE Personal Data Protection Law (PDPL) and the 2026 CDS Law governing consent for minors.
✅ ISO 9001:2015 Certified — Certificate Number: INT/EGQ/2509DA/3139. Quality management system audited and verified by internationally accredited bodies.
✅ DHA Licensed Facility — License Number: 9834453. All clinical personnel hold valid DHA professional licenses and participate in continuous medical education programs compliant with the 2026 E-E-A-T medical content standards.
✅ Patient Rights: You retain absolute ownership of your genetic data. Results are released exclusively to the ordering physician and the patient (or legal guardian, per CDS 2026 minors' provisions). No genomic data is shared with third parties without explicit, revocable written consent.
Book Your SUCLG1 Genetic Today
Home Collection • Insurance Verified • 3–4 Week TAT • 2800 AED
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians